Protein: SPOUT
28S rRNA (uridine-N(3))-methyltransferase (EC 2.1.1.-) (Centromere protein 32) (CENP-32) (Kinetochore-associated protein) (Methyltransferase C9orf114) (Ribosomal RNA methyltransferase SPOUT1) (SPOUT domain-containing methyltransferase 1)

Gene: SPOUT, SPOUT1
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q5T280

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0003723 - RNA binding
GO:0005737 - cytoplasm
GO:0010608 - post-transcriptional regulation of gene expression
GO:0031616 - spindle pole centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

898685

RL14
Large ribosomal subunit protein eL14

2

0

High-throughput

0.585

High

1037192

H11
Histone H1.1

2

1

High-throughput

0.558

High

1081385

INCA1
Protein INCA1

1

0

Small-scale

0.529

High

472803

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.513

High

904820

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

1212085

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

1212086

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.513

High

1212095

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.513

High

1212102

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.513

High

178029

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

0

High-throughput

0.493

High

649330

H1T
Histone H1t

1

1

High-throughput

0.489

High

920020

PLK1
Serine/threonine-protein kinase PLK1

1

0

High-throughput

0.486

High

995078

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.486

High

257878

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

2

Small-scale

0.479

High

1212079

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.470

High

129162

MEN1
Menin

1

0

High-throughput

0.458

High

215121

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.458

High

325874

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

High-throughput

0.458

High

342907

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

345922

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

400963

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

810152

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

885805

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.458

High

992493

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

1024620

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1087662

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

0

High-throughput

0.458

High

1139624

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

1155446

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1156739

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1168513

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.458

High

1197620

MIDN
Midnolin

1

0

High-throughput

0.458

High

1212071

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.458

High

1212072

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1212073

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1212075

SRRM1
Serine/arginine repetitive matrix protein 1

1

0

High-throughput

0.458

High

1212077

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1212080

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1212081

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

Small-scale

0.458

High

1212082

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1212084

BROMI
Protein broad-minded

1

0

Small-scale

0.458

High

1212091

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1212096

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1212098

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1212099

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1212097

WRP73
WD repeat-containing protein WRAP73

1

1

Small-scale

0.445

High

285327

EED
Polycomb protein EED

1

2

High-throughput

0.437

High

871946

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.437

High

1137758

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.437

High

1212076

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

1

High-throughput

0.437

High

1212101

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

288671

NPM3
Nucleoplasmin-3

1

0

High-throughput

0.426

High

430015

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

563882

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

601715

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.426

High

860781

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.426

High

1132375

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1212090

REXO4
RNA exonuclease 4

1

0

High-throughput

0.426

High

1212092

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1212093

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.426

High

1212100

ZN346
Zinc finger protein 346

1

0

High-throughput

0.426

High

1212103

RBMX2
RNA-binding motif protein, X-linked 2

1

0

High-throughput

0.426

High

1212083

EAF1
ELL-associated factor 1

2

0

High-throughput

0.318

High

191668

MAGB2
Melanoma-associated antigen B2

2

0

High-throughput

0.313

High

372239

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.305

High

1212078

ESR2
Estrogen receptor beta

2

0

High-throughput

0.298

High

833126

MNDA
Myeloid cell nuclear differentiation antigen

1

0

High-throughput

0.279

Low

1212087

ZNF2
Zinc finger protein 2

1

0

High-throughput

0.279

Low

1212089

TSSK6
Testis-specific serine/threonine-protein kinase 6

1

0

High-throughput

0.279

Low

185763

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

157478

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

209284

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

0

High-throughput

0.249

Low

720489

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

937779

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

1124347

ELOA1
Elongin-A

1

0

High-throughput

0.249

Low

1126103

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1137339

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

1212074

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low

1212088

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

1212094

ANLN
Anillin

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025