Protein: GRM1
Metabotropic glutamate receptor 1 (mGluR1)

Gene: GRM1
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q13255

Gene Ontology (top 5):
GO:0001640 - adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0004930 - G protein-coupled receptor activity
GO:0005634 - nucleus
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1099648

GRM1
Metabotropic glutamate receptor 1

4

14

Small-scale

0.878

High

832605

CASR
Extracellular calcium-sensing receptor

1

15

Small-scale

0.724

High

217434

E41L2
Band 4.1-like protein 2

1

1

Small-scale

0.561

High

1099662

CABIN
Calcineurin-binding protein cabin-1

1

2

Small-scale

0.561

High

1099658

OPTN
Optineurin

1

2

Small-scale

0.552

High

770851

OPRM
Mu-type opioid receptor

1

6

High-throughput

0.541

High

911228

IMA5
Importin subunit alpha-5

1

1

Small-scale

0.515

High

371933

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.501

High

400767

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.501

High

410810

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

6

High-throughput

0.501

High

465505

IGF1R
Insulin-like growth factor 1 receptor

1

2

High-throughput

0.501

High

549139

CDK4
Cyclin-dependent kinase 4

1

3

High-throughput

0.501

High

593355

PGFRA
Platelet-derived growth factor receptor alpha

1

3

High-throughput

0.501

High

648500

FGFR4
Fibroblast growth factor receptor 4

1

4

High-throughput

0.501

High

710219

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.501

High

767193

MERL
Merlin

1

1

High-throughput

0.501

High

842914

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

3

High-throughput

0.501

High

842956

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

3

High-throughput

0.501

High

1025336

CDK6
Cyclin-dependent kinase 6

1

3

High-throughput

0.501

High

1099656

KAT2A
Histone acetyltransferase KAT2A

1

1

High-throughput

0.501

High

1099657

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

High-throughput

0.501

High

1099660

LATS2
Serine/threonine-protein kinase LATS2

1

2

High-throughput

0.501

High

1099661

RASF1
Ras association domain-containing protein 1

1

7

High-throughput

0.501

High

1099649

ZMYM3
Zinc finger MYM-type protein 3

1

0

High-throughput

0.493

High

162939

TERT
Telomerase reverse transcriptase

1

0

High-throughput

0.480

High

591292

CD44
CD44 antigen

1

0

High-throughput

0.480

High

666984

CCNE1
G1/S-specific cyclin-E1

1

0

High-throughput

0.480

High

718810

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.480

High

1099652

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

1099659

TTYH2
Protein tweety homolog 2

1

0

High-throughput

0.480

High

138678

IMA4
Importin subunit alpha-4

1

1

Small-scale

0.479

High

345755

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

390034

ALBU
Albumin

1

1

High-throughput

0.479

High

440533

FYN
Tyrosine-protein kinase Fyn

1

3

Small-scale

0.479

High

557277

SRC
Proto-oncogene tyrosine-protein kinase Src

1

3

Small-scale

0.479

High

669125

ARBK1
Beta-adrenergic receptor kinase 1

1

1

Small-scale

0.479

High

720585

AA1R
Adenosine receptor A1

1

5

Small-scale

0.479

High

732566

ARRB2
Beta-arrestin-2

1

1

Small-scale

0.479

High

849160

KSYK
Tyrosine-protein kinase SYK

1

11

Small-scale

0.479

High

878226

TRPC1
Short transient receptor potential channel 1

1

1

Small-scale

0.479

High

882472

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.479

High

1099650

FAK2
Protein-tyrosine kinase 2-beta

1

8

Small-scale

0.479

High

1099653

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.479

High

1099654

GRASP
Protein TAMALIN

1

15

Small-scale

0.479

High

1099655

HOME1
Homer protein homolog 1

1

10

Small-scale

0.479

High

623317

RO52
E3 ubiquitin-protein ligase TRIM21

1

0

High-throughput

0.458

High

843529

HD
Huntingtin

1

0

Small-scale

0.458

High

1097091

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

1

High-throughput

0.457

High

755478

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

1099651

BECN1
Beclin-1

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025