Protein: HAKAI
E3 ubiquitin-protein ligase Hakai (EC 2.3.2.27) (Casitas B-lineage lymphoma-transforming sequence-like protein 1) (c-Cbl-like protein 1) (RING finger protein 188) (RING-type E3 ubiquitin transferase Hakai)

Gene: HAKAI, CBLL1
Organism: Homo sapiens
Interactions: 74
UniProt ID: Q75N03

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

556173

CADH1
Cadherin-1

9

4

Small-scale

0.751

High

396391

ESR1
Estrogen receptor

3

20

Small-scale

0.658

High

557356

SRC
Proto-oncogene tyrosine-protein kinase Src

3

8

Small-scale

0.656

High

1229540

VIR
Protein virilizer homolog

2

3

High-throughput

0.611

High

1023097

RBM10
RNA-binding protein 10

1

1

High-throughput

0.541

High

141542

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.536

High

187741

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

Small-scale

0.536

High

227103

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

Small-scale

0.536

High

228295

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

1

Small-scale

0.536

High

608643

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

Small-scale

0.536

High

613378

VINC
Vinculin

1

2

Small-scale

0.536

High

686227

RL13
Large ribosomal subunit protein eL13

1

1

Small-scale

0.536

High

687830

SYVC
Valine--tRNA ligase

1

2

Small-scale

0.536

High

876036

TCPE
T-complex protein 1 subunit epsilon

1

1

Small-scale

0.536

High

881221

FAS
Fatty acid synthase

1

1

Small-scale

0.536

High

953919

IF4A1
Eukaryotic initiation factor 4A-I

1

9

Small-scale

0.536

High

1039264

RL6
Large ribosomal subunit protein eL6

1

1

Small-scale

0.536

High

1057781

RL18
Large ribosomal subunit protein eL18

1

1

Small-scale

0.536

High

1059881

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

Small-scale

0.536

High

1061034

SRSF1
Serine/arginine-rich splicing factor 1

1

1

Small-scale

0.536

High

1100042

TIF1B
Transcription intermediary factor 1-beta

1

10

Small-scale

0.536

High

1115759

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.536

High

1136456

FL2D
Pre-mRNA-splicing regulator WTAP

1

1

High-throughput

0.536

High

1160178

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

13

Small-scale

0.536

High

1178510

KI26B
Kinesin-like protein KIF26B

1

5

High-throughput

0.536

High

1260286

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.536

High

1260291

DDX17
Probable ATP-dependent RNA helicase DDX17

1

8

Small-scale

0.536

High

1260297

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.536

High

920835

ACLY
ATP-citrate synthase

1

0

Small-scale

0.513

High

1008209

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.513

High

1158397

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.513

High

1161016

FSCN1
Fascin

1

0

Small-scale

0.513

High

185801

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

6

High-throughput

0.501

High

691167

1433T
14-3-3 protein theta

1

19

High-throughput

0.501

High

955317

CDC42
Cell division control protein 42 homolog

1

9

Small-scale

0.501

High

1013304

HTRA4
Serine protease HTRA4

1

1

High-throughput

0.489

High

1120858

DGCR6
Protein DGCR6

1

1

High-throughput

0.481

High

143075

NFIB
Nuclear factor 1 B-type

1

12

High-throughput

0.479

High

375652

RASK
GTPase KRas

1

5

High-throughput

0.479

High

406314

MYCN
N-myc proto-oncogene protein

1

18

High-throughput

0.479

High

456773

ANXA2
Annexin A2

1

1

Small-scale

0.479

High

588993

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

655244

SFPQ
Splicing factor, proline- and glutamine-rich

1

3

Small-scale

0.479

High

695781

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

786691

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

High-throughput

0.479

High

904863

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

979877

H4
Histone H4

1

4

High-throughput

0.479

High

990399

1433Z
14-3-3 protein zeta/delta

1

19

High-throughput

0.479

High

1004749

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1048015

TLE3
Transducin-like enhancer protein 3

1

8

High-throughput

0.479

High

1083392

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

1

High-throughput

0.479

High

1089451

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.479

High

1113498

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1124632

SRC8
Src substrate cortactin

1

18

Small-scale

0.479

High

1137362

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1155488

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

1260287

ZCH18
Zinc finger CCCH domain-containing protein 18

1

8

High-throughput

0.479

High

1260288

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1260289

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1260290

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1260292

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

6

High-throughput

0.479

High

1260293

PDLI5
PDZ and LIM domain protein 5

1

1

Small-scale

0.479

High

1260294

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

1260295

DOK1
Docking protein 1

1

1

Small-scale

0.479

High

1260296

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.479

High

1260298

ANLN
Anillin

1

2

High-throughput

0.479

High

1260299

RNC
Ribonuclease 3

1

4

High-throughput

0.479

High

1260300

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1260301

XPO7
Exportin-7

1

10

High-throughput

0.479

High

768497

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1260302

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

1

High-throughput

0.417

High

829441

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

Small-scale

0.279

Low

932896

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

Small-scale

0.279

Low

1163679

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

Small-scale

0.279

Low


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Last updated: 11Aug2025