Protein: PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PEPCK-M) (EC 4.1.1.32) (Phosphoenolpyruvate carboxykinase 2, mitochondrial) (mtPCK2)

Gene: PCKGM, PCK2
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q16822

Gene Ontology (top 5):
GO:0004611 - phosphoenolpyruvate carboxykinase activity
GO:0004613 - phosphoenolpyruvate carboxykinase (GTP) activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

772390

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

2

0

High-throughput

0.770

High

532622

CH60
60 kDa heat shock protein, mitochondrial

2

1

High-throughput

0.611

High

278673

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.602

High

560863

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

2

0

High-throughput

0.602

High

1123565

ZMYM3
Zinc finger MYM-type protein 3

2

4

High-throughput

0.574

High

1163676

ZMYM4
Zinc finger MYM-type protein 4

2

5

High-throughput

0.574

High

1163680

AHNK2
Protein AHNAK2

2

1

High-throughput

0.574

High

1163687

BPIB1
BPI fold-containing family B member 1

2

1

High-throughput

0.574

High

1163707

BPIA1
BPI fold-containing family A member 1

2

1

High-throughput

0.574

High

1163713

ZMYM2
Zinc finger MYM-type protein 2

2

4

High-throughput

0.574

High

1163716

DMBT1
Scavenger receptor cysteine-rich domain-containing protein DMBT1

2

2

High-throughput

0.574

High

1035000

KPCE
Protein kinase C epsilon type

2

1

High-throughput

0.571

High

400905

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

1014529

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.549

High

424663

KPCG
Protein kinase C gamma type

2

2

High-throughput

0.521

High

321095

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.513

High

786114

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.513

High

1163681

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1163694

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.513

High

1163703

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.513

High

1163711

CWC15
Spliceosome-associated protein CWC15 homolog

1

0

High-throughput

0.513

High

379647

IGHA1
Immunoglobulin heavy constant alpha 1

2

1

High-throughput

0.504

High

379742

IGHA2
Immunoglobulin heavy constant alpha 2

2

1

High-throughput

0.504

High

1068219

AHNK
Neuroblast differentiation-associated protein AHNAK

1

1

High-throughput

0.489

High

404092

GCR
Glucocorticoid receptor

1

3

High-throughput

0.479

High

964985

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

1163695

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1163696

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1163699

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

241827

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

348522

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

412009

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

471048

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

1090413

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1147600

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.458

High

1162344

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1163689

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1163705

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

422201

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

1163718

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

1067405

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.439

High

372162

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

845311

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

High-throughput

0.437

High

879151

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

907457

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.437

High

984135

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.437

High

1047909

TLE2
Transducin-like enhancer protein 2

1

3

High-throughput

0.437

High

1099954

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.437

High

1114855

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

1163678

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1163686

COP1
E3 ubiquitin-protein ligase COP1

1

4

High-throughput

0.437

High

1163690

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.437

High

1135887

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

1163675

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

607302

NEUM
Neuromodulin

2

0

High-throughput

0.328

High

1163691

PAUF
Pancreatic adenocarcinoma up-regulated factor

2

0

High-throughput

0.328

High

1163702

LACRT
Extracellular glycoprotein lacritin

2

0

High-throughput

0.328

High

1163706

MUC5B
Mucin-5B

2

0

High-throughput

0.328

High

1163712

RCOR3
REST corepressor 3

2

0

High-throughput

0.328

High

1163717

SUFU
Suppressor of fused homolog

2

0

High-throughput

0.328

High

378994

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.279

Low

1142066

P2RY6
P2Y purinoceptor 6

1

0

High-throughput

0.279

Low

1163679

HAKAI
E3 ubiquitin-protein ligase Hakai

1

0

Small-scale

0.279

Low

1163688

PRCC
Proline-rich protein PRCC

1

0

High-throughput

0.279

Low

1163692

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1163697

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.279

Low

1163698

BBS2
BBSome complex member BBS2

1

0

High-throughput

0.279

Low

1163701

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.279

Low

1163704

MUC13
Mucin-13

1

0

High-throughput

0.279

Low

1163709

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.279

Low

106022

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

130116

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

227575

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

423780

APOD
Apolipoprotein D

1

0

High-throughput

0.249

Low

710271

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.249

Low

883254

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.249

Low

942651

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.249

Low

1135694

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

1136218

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

1140342

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.249

Low

1163677

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1163682

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1163683

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1163684

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1163685

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1163714

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1163715

TES
Testin

1

0

High-throughput

0.249

Low

1163693

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.232

Low

1163700

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low

1163708

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

1163710

SPHK1
Sphingosine kinase 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025