Protein: UBR1
E3 ubiquitin-protein ligase UBR1 (EC 2.3.2.27) (N-end-recognizing protein) (N-recognin-1)

Gene: UBR1
Organism: Saccharomyces cerevisiae S288C
Interactions: 58
UniProt ID: P19812

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm
GO:0006513 - protein monoubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

438519

UBC2
Ubiquitin-conjugating enzyme E2 2

16

14

Small-scale

0.986

High

625964

CUP9
Homeobox protein CUP9

6

1

Small-scale

0.669

High

509387

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

2

Small-scale

0.647

High

625936

UBR1
E3 ubiquitin-protein ligase UBR1

1

2

Small-scale

0.647

High

523013

HSP71
Heat shock protein SSA1

3

2

Small-scale

0.624

High

625966

YJO4
Uncharacterized protein YJL144W

2

0

Small-scale

0.607

High

625951

UFD4
Ubiquitin fusion degradation protein 4

2

0

Small-scale

0.606

High

625957

CHK1
Serine/threonine-protein kinase CHK1

2

0

Small-scale

0.596

High

625938

MCK1
Protein kinase MCK1

1

2

Small-scale

0.586

High

625972

PRS8
26S proteasome regulatory subunit 8 homolog

1

1

Small-scale

0.578

High

625952

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

Small-scale

0.561

High

625975

VAM6
Vacuolar morphogenesis protein 6

2

0

Small-scale

0.559

High

625940

SIS1
Protein SIS1

2

0

Small-scale

0.547

High

625948

RPN2
26S proteasome regulatory subunit RPN2

1

0

Small-scale

0.537

High

574550

YAK1
Dual specificity protein kinase YAK1

1

0

High-throughput

0.513

High

625937

PP11
Serine/threonine-protein phosphatase PP1-1

1

0

High-throughput

0.513

High

625946

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

High-throughput

0.513

High

625960

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.513

High

625939

KC11
Casein kinase I homolog 1

1

0

Small-scale

0.493

High

625955

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.489

High

598354

ATE1
Arginyl-tRNA--protein transferase 1

1

1

Small-scale

0.481

High

625958

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

Small-scale

0.480

High

625942

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

625950

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

625945

RAD16
DNA repair protein RAD16

1

0

Small-scale

0.460

High

460374

DYR
Dihydrofolate reductase

1

0

Small-scale

0.458

High

625944

RENT1
ATP-dependent helicase NAM7

1

0

Small-scale

0.458

High

625947

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

625954

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

Small-scale

0.458

High

625959

NMD2
Nonsense-mediated mRNA decay protein 2

1

0

Small-scale

0.458

High

625969

CDH1
APC/C activator protein CDH1

1

0

Small-scale

0.458

High

625970

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

625971

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

625974

AVO2
Target of rapamycin complex 2 subunit AVO2

1

0

Small-scale

0.458

High

543771

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

625949

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

625961

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

557661

SRS2
ATP-dependent DNA helicase SRS2

1

1

Small-scale

0.439

High

625963

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.437

High

510177

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.426

High

625965

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

625967

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

625973

ADA2
SAGA complex subunit ADA2

1

0

High-throughput

0.426

High

408458

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

Small-scale

0.391

High

625941

MGMT
Methylated-DNA--protein-cysteine methyltransferase

4

0

Small-scale

0.364

High

625976

SCC1
Sister chromatid cohesion protein 1

2

0

Small-scale

0.310

High

618544

FAS2
Fatty acid synthase subunit alpha

2

0

Small-scale

0.305

High

625956

CENPA
Histone H3-like centromeric protein CSE4

2

0

Small-scale

0.305

High

547027

PPB
Repressible alkaline phosphatase

1

0

Small-scale

0.279

Low

625968

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

625962

PSA4
Proteasome subunit alpha type-4

1

0

Small-scale

0.269

Low

556557

STE6
Alpha-factor-transporting ATPase

1

0

Small-scale

0.249

Low

603002

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.249

Low

625953

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

625977

NDOR1
NADPH-dependent diflavin oxidoreductase 1

1

0

Small-scale

0.249

Low

625978

SMC6
Structural maintenance of chromosomes protein 6

1

0

High-throughput

0.249

Low

625943

PSB5
Proteasome subunit beta type-5

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025