Protein: RPA43
DNA-directed RNA polymerase I subunit RPA43 (A43) (DNA-directed DNA-dependent RNA polymerase 36 kDa polypeptide)

Gene: RPA43
Organism: Saccharomyces cerevisiae S288C
Interactions: 84
UniProt ID: P46669

Gene Ontology (top 5):
GO:0003899 - DNA-directed RNA polymerase activity
GO:0005634 - nucleus
GO:0005736 - RNA polymerase I complex
GO:0006360 - transcription by RNA polymerase I
GO:0006361 - transcription initiation at RNA polymerase I promoter

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

534276

RPA1
DNA-directed RNA polymerase I subunit RPA190

12

1

Small-scale

0.977

High

644947

RPA2
DNA-directed RNA polymerase I subunit RPA135

9

1

Small-scale

0.965

High

858235

RPA14
DNA-directed RNA polymerase I subunit RPA14

8

0

Small-scale

0.921

High

632268

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

5

1

Small-scale

0.908

High

858242

RPA49
DNA-directed RNA polymerase I subunit RPA49

8

1

Small-scale

0.745

High

780572

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

1

Small-scale

0.737

High

459119

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

5

1

Small-scale

0.714

High

632178

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

5

1

Small-scale

0.714

High

739536

RPA12
DNA-directed RNA polymerase I subunit RPA12

5

1

Small-scale

0.714

High

858232

RPA34
DNA-directed RNA polymerase I subunit RPA34

4

0

Small-scale

0.653

High

645068

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

3

1

Small-scale

0.650

High

700015

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

3

1

Small-scale

0.650

High

823712

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

3

1

Small-scale

0.650

High

632354

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

3

0

Small-scale

0.628

High

858233

NET1
Nucleolar protein NET1

3

1

Small-scale

0.593

High

826609

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.559

High

858256

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.537

High

807097

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

Small-scale

0.536

High

545335

SSB1
Ribosome-associated molecular chaperone SSB1

2

0

High-throughput

0.528

High

661175

SPT6
Transcription elongation factor SPT6

1

0

Small-scale

0.486

High

694577

SPT5
Transcription elongation factor SPT5

1

0

Small-scale

0.486

High

858246

RRP5
rRNA biogenesis protein RRP5

1

0

Small-scale

0.481

High

448752

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.480

High

656522

KC11
Casein kinase I homolog 1

1

0

High-throughput

0.480

High

748864

SWE1
Mitosis inhibitor protein kinase SWE1

1

0

High-throughput

0.480

High

792850

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.480

High

858240

SEN1
Helicase SEN1

1

1

High-throughput

0.479

High

382178

H4
Histone H4

1

0

High-throughput

0.458

High

435183

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

488967

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

561492

TBP
TATA-box-binding protein

1

0

Small-scale

0.458

High

638808

REB1
DNA-binding protein REB1

1

0

Small-scale

0.458

High

668276

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

704620

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.458

High

707457

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

709844

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

735042

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

750712

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

795958

RRN10
RNA polymerase I-specific transcription initiation factor RRN10

1

0

High-throughput

0.458

High

803597

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

808845

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

822995

ATAD2
ATPase histone chaperone YTA7

1

0

High-throughput

0.458

High

858237

RRN9
RNA polymerase I-specific transcription initiation factor RRN9

1

0

High-throughput

0.458

High

858238

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

858239

H3
Histone H3

1

0

High-throughput

0.458

High

858241

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.458

High

858247

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

858250

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.458

High

858251

SGO1
Shugoshin

1

0

High-throughput

0.458

High

858255

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

858248

FKBP4
FK506-binding protein 4

1

1

Small-scale

0.445

High

858244

TOF2
Topoisomerase 1-associated factor 2

1

1

High-throughput

0.437

High

858252

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

858254

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

1

High-throughput

0.437

High

524347

HSP71
Heat shock protein SSA1

1

0

High-throughput

0.426

High

689529

RS7A
Small ribosomal subunit protein eS7A

1

0

Small-scale

0.426

High

727135

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

811342

CAJ1
Protein CAJ1

1

0

High-throughput

0.426

High

779551

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.407

High

858231

RS10B
Small ribosomal subunit protein eS10B

1

1

Small-scale

0.407

High

751426

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

Small-scale

0.298

High

700253

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.282

High

692385

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.261

Low

858236

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

383768

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

455129

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

503114

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

512510

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

513082

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

514698

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

579623

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

585304

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.249

Low

674696

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

747441

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.249

Low

753443

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

753688

TOM6
Mitochondrial import receptor subunit TOM6

1

0

High-throughput

0.249

Low

802243

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

844509

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

858234

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

858243

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

858245

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.249

Low

858249

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.249

Low

858253

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

738220

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025