Protein: PHF6
PHD finger protein 6 (PHD-like zinc finger protein)

Gene: PHF6
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q8IWS0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000776 - kinetochore
GO:0001835 - blastocyst hatching
GO:0003677 - DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

347260

MYC
Myc proto-oncogene protein

4

9

High-throughput

0.672

High

1219322

LYAR
Cell growth-regulating nucleolar protein

3

1

Small-scale

0.640

High

997796

RBBP4
Histone-binding protein RBBP4

2

17

Small-scale

0.639

High

942779

SRPK2
SRSF protein kinase 2

2

5

High-throughput

0.619

High

1041982

CUL3
Cullin-3

2

5

High-throughput

0.611

High

227982

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

244638

BRD4
Bromodomain-containing protein 4

2

19

High-throughput

0.584

High

707682

H2B1B
Histone H2B type 1-B

2

20

Small-scale

0.584

High

369955

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

1043933

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

9

High-throughput

0.571

High

440609

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

2

High-throughput

0.536

High

470444

H2A1
Histone H2A type 1

1

11

High-throughput

0.536

High

489141

H14
Histone H1.4

1

6

High-throughput

0.536

High

642440

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

649597

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.536

High

900047

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

1

High-throughput

0.536

High

1019014

TP53B
TP53-binding protein 1

1

4

High-throughput

0.536

High

1033392

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.536

High

1219306

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

1

High-throughput

0.536

High

1219324

DAXX
Death domain-associated protein 6

1

3

High-throughput

0.536

High

1173128

SYDE1
Rho GTPase-activating protein SYDE1

2

4

High-throughput

0.521

High

907389

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

916682

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

1162982

CPLX2
Complexin-2

1

0

High-throughput

0.513

High

1201977

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

175025

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

9

High-throughput

0.501

High

1219310

KLF16
Krueppel-like factor 16

1

16

High-throughput

0.500

High

972344

TIE2
Angiopoietin-1 receptor

1

9

High-throughput

0.489

High

262503

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

272196

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

6

Small-scale

0.479

High

295002

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

322851

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

4

High-throughput

0.479

High

374505

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.479

High

377467

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

379585

MYCN
N-myc proto-oncogene protein

1

9

High-throughput

0.479

High

391780

H2A1B
Histone H2A type 1-B/E

1

11

High-throughput

0.479

High

400980

RLA0
Large ribosomal subunit protein uL10

1

2

Small-scale

0.479

High

418439

NPM
Nucleophosmin

1

3

Small-scale

0.479

High

432799

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

6

Small-scale

0.479

High

442292

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

455629

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

470081

H2AZ
Histone H2A.Z

1

15

Small-scale

0.479

High

486809

MYB
Transcriptional activator Myb

1

4

High-throughput

0.479

High

559809

H12
Histone H1.2

1

6

Small-scale

0.479

High

603587

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

Small-scale

0.479

High

609948

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

Small-scale

0.479

High

682630

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

Small-scale

0.479

High

684863

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

717994

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.479

High

718975

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

722450

RL22
Large ribosomal subunit protein eL22

1

1

Small-scale

0.479

High

729667

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.479

High

739763

SRP14
Signal recognition particle 14 kDa protein

1

1

Small-scale

0.479

High

750342

COIL
Coilin

1

5

High-throughput

0.479

High

817700

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

822084

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

824171

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

830413

KC1E
Casein kinase I isoform epsilon

1

5

High-throughput

0.479

High

850944

HDGF
Hepatoma-derived growth factor

1

6

High-throughput

0.479

High

852102

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

Small-scale

0.479

High

877792

FOXA1
Hepatocyte nuclear factor 3-alpha

1

9

High-throughput

0.479

High

900666

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

908785

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

917553

H4
Histone H4

1

13

High-throughput

0.479

High

918501

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

921897

RL30
Large ribosomal subunit protein eL30

1

1

Small-scale

0.479

High

925418

RAC1
Ras-related C3 botulinum toxin substrate 1

1

4

High-throughput

0.479

High

941132

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

962198

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

13

Small-scale

0.479

High

974603

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

998871

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

1018567

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

12

Small-scale

0.479

High

1035874

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1038514

HDAC1
Histone deacetylase 1

1

13

Small-scale

0.479

High

1051974

ELOA1
Elongin-A

1

3

High-throughput

0.479

High

1059718

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

11

Small-scale

0.479

High

1063933

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1072131

PCBP2
Poly(rC)-binding protein 2

1

2

Small-scale

0.479

High

1083306

RBBP7
Histone-binding protein RBBP7

1

17

Small-scale

0.479

High

1116375

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1136158

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1184202

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.479

High

1200477

NAA40
N-alpha-acetyltransferase 40

1

1

High-throughput

0.479

High

1219292

SMC5
Structural maintenance of chromosomes protein 5

1

5

High-throughput

0.479

High

1219294

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

5

High-throughput

0.479

High

1219298

PHIP
PH-interacting protein

1

20

Small-scale

0.479

High

1219300

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1219301

FBXW7
F-box/WD repeat-containing protein 7

1

11

High-throughput

0.479

High

1219305

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

1219307

LMTK3
Serine/threonine-protein kinase LMTK3

1

12

High-throughput

0.479

High

1219308

TBA1C
Tubulin alpha-1C chain

1

1

Small-scale

0.479

High

1219316

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.479

High

1219318

RC3H2
Roquin-2

1

10

High-throughput

0.479

High

1219319

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

1219320

BRD7
Bromodomain-containing protein 7

1

17

High-throughput

0.479

High

1219325

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1219327

RALY
RNA-binding protein Raly

1

4

Small-scale

0.479

High

1219328

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.479

High

1219329

FZR1
Fizzy-related protein homolog

1

17

High-throughput

0.479

High

1219332

ZN330
Zinc finger protein 330

1

7

High-throughput

0.479

High

161841

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

182818

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

233536

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

298635

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

299413

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

519031

PIP
Prolactin-inducible protein

1

0

Small-scale

0.458

High

591012

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

736570

RL4
Large ribosomal subunit protein uL4

1

0

Small-scale

0.458

High

779705

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

899517

MGN
Protein mago nashi homolog

1

0

Small-scale

0.458

High

910878

RS18
Small ribosomal subunit protein uS13

1

0

Small-scale

0.458

High

920497

RS25
Small ribosomal subunit protein eS25

1

0

Small-scale

0.458

High

929225

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

1119554

MIDN
Midnolin

1

0

High-throughput

0.458

High

1159179

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

Small-scale

0.458

High

1219293

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1219302

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1219303

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

1219314

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1219321

ANLN
Anillin

1

0

High-throughput

0.458

High

1219326

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

666620

LTK
Leukocyte tyrosine kinase receptor

1

6

High-throughput

0.457

High

402222

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

1059318

CASP8
Caspase-8

1

6

High-throughput

0.445

High

1219317

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

385130

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

445857

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

10

High-throughput

0.437

High

572652

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.437

High

609408

FGFR3
Fibroblast growth factor receptor 3

1

8

High-throughput

0.437

High

674476

UFO
Tyrosine-protein kinase receptor UFO

1

6

High-throughput

0.437

High

674692

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.437

High

738234

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

894195

CDC42
Cell division control protein 42 homolog

1

4

High-throughput

0.437

High

1018171

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

5

High-throughput

0.437

High

1133683

RHG21
Rho GTPase-activating protein 21

1

2

High-throughput

0.437

High

1170710

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1219295

KDF1
Keratinocyte differentiation factor 1

1

1

High-throughput

0.437

High

1219309

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.437

High

1219311

RHBT2
Rho-related BTB domain-containing protein 2

1

4

High-throughput

0.437

High

1219312

TRI31
E3 ubiquitin-protein ligase TRIM31

1

7

High-throughput

0.437

High

1219315

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1219323

HECW2
E3 ubiquitin-protein ligase HECW2

1

4

High-throughput

0.437

High

170683

AXIN1
Axin-1

1

0

Small-scale

0.426

High

831475

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.408

High

873291

EMP3
Epithelial membrane protein 3

1

0

High-throughput

0.279

Low

1219299

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

1219304

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1219330

KLH20
Kelch-like protein 20

1

0

High-throughput

0.279

Low

1219331

AP3M1
AP-3 complex subunit mu-1

1

0

High-throughput

0.279

Low

1219296

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

1219297

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1219313

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024