Protein: CDKA1
Cyclin-dependent kinase 2-associated protein 1 (CDK2-associated protein 1) (Deleted in oral cancer 1) (DOC-1) (Putative oral cancer suppressor)

Gene: CDKA1, CDK2AP1
Organism: Homo sapiens
Interactions: 121
UniProt ID: O14519

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0001934 - positive regulation of protein phosphorylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

155304

HDAC1
Histone deacetylase 1

9

6

Small-scale

0.752

High

155310

RBBP7
Histone-binding protein RBBP7

9

4

Small-scale

0.750

High

155305

CHD4
Chromodomain-helicase-DNA-binding protein 4

8

9

Small-scale

0.747

High

155335

HDAC2
Histone deacetylase 2

8

6

Small-scale

0.747

High

155298

RBBP4
Histone-binding protein RBBP4

7

4

Small-scale

0.744

High

155320

P66A
Transcriptional repressor p66-alpha

7

3

Small-scale

0.744

High

155334

P66B
Transcriptional repressor p66-beta

7

3

Small-scale

0.744

High

155269

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

2

Small-scale

0.740

High

155300

CHD3
Chromodomain-helicase-DNA-binding protein 3

6

9

Small-scale

0.730

High

155273

MBD3
Methyl-CpG-binding domain protein 3

6

5

Small-scale

0.727

High

155365

MBD2
Methyl-CpG-binding domain protein 2

6

5

Small-scale

0.727

High

155347

MTA3
Metastasis-associated protein MTA3

6

8

Small-scale

0.722

High

155364

ZN219
Zinc finger protein 219

5

2

High-throughput

0.718

High

155271

MTA2
Metastasis-associated protein MTA2

5

8

Small-scale

0.709

High

155303

MTA1
Metastasis-associated protein MTA1

5

8

Small-scale

0.703

High

155333

MB3L1
Methyl-CpG-binding domain protein 3-like 1

3

5

High-throughput

0.667

High

155339

MR1L1
MORF4 family-associated protein 1-like 1

5

2

High-throughput

0.661

High

155329

CHD5
Chromodomain-helicase-DNA-binding protein 5

3

9

High-throughput

0.650

High

155373

STRAP
Serine-threonine kinase receptor-associated protein

2

2

High-throughput

0.628

High

155326

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

1

High-throughput

0.611

High

155350

BC11B
B-cell lymphoma/leukemia 11B

2

4

High-throughput

0.611

High

155291

IMA5
Importin subunit alpha-5

2

3

High-throughput

0.601

High

155369

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

2

2

High-throughput

0.584

High

155325

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.580

High

155338

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

155353

CARD9
Caspase recruitment domain-containing protein 9

2

0

High-throughput

0.580

High

155360

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

155362

SPG21
Maspardin

2

0

High-throughput

0.580

High

155371

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

0

High-throughput

0.580

High

155336

SGF29
SAGA-associated factor 29

2

0

High-throughput

0.576

High

155256

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

2

Small-scale

0.575

High

155276

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

155287

CDK2
Cyclin-dependent kinase 2

1

0

Small-scale

0.537

High

155259

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

2

High-throughput

0.536

High

155260

HDAC3
Histone deacetylase 3

1

6

High-throughput

0.536

High

155263

IMA7
Importin subunit alpha-7

1

3

High-throughput

0.536

High

155265

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

2

High-throughput

0.536

High

155272

PHF14
PHD finger protein 14

1

1

High-throughput

0.536

High

155319

RAI1
Retinoic acid-induced protein 1

1

1

High-throughput

0.536

High

155323

ZN687
Zinc finger protein 687

1

2

High-throughput

0.536

High

155346

MEP50
Methylosome protein WDR77

1

2

High-throughput

0.536

High

155348

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

2

High-throughput

0.536

High

155366

TCF20
Transcription factor 20

1

1

High-throughput

0.536

High

155368

TRPS1
Zinc finger transcription factor Trps1

1

3

High-throughput

0.536

High

155278

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.513

High

155282

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

155283

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

155294

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.513

High

155311

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

155312

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.513

High

155322

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

155332

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.513

High

155354

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

155356

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.513

High

155359

HM20A
High mobility group protein 20A

1

0

High-throughput

0.513

High

155372

SHLB1
Endophilin-B1

1

0

High-throughput

0.513

High

155279

DPOLA
DNA polymerase alpha catalytic subunit

1

0

Small-scale

0.480

High

155261

PHF1
PHD finger protein 1

1

1

High-throughput

0.479

High

155262

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

9

High-throughput

0.479

High

155264

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

155266

SIN3B
Paired amphipathic helix protein Sin3b

1

1

High-throughput

0.479

High

155268

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

155270

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

2

High-throughput

0.479

High

155277

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

155285

CBL
E3 ubiquitin-protein ligase CBL

1

1

High-throughput

0.479

High

155288

BRD2
Bromodomain-containing protein 2

1

2

High-throughput

0.479

High

155289

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

9

High-throughput

0.479

High

155297

ERCC6
DNA excision repair protein ERCC-6

1

10

High-throughput

0.479

High

155299

BPTF
Nucleosome-remodeling factor subunit BPTF

1

5

High-throughput

0.479

High

155302

CAF1B
Chromatin assembly factor 1 subunit B

1

3

High-throughput

0.479

High

155306

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

10

High-throughput

0.479

High

155308

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

155315

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

1

High-throughput

0.479

High

155330

ZN296
Zinc finger protein 296

1

4

High-throughput

0.479

High

155341

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.479

High

155344

PHF12
PHD finger protein 12

1

9

High-throughput

0.479

High

155345

SIN3A
Paired amphipathic helix protein Sin3a

1

1

High-throughput

0.479

High

155352

BC11A
BCL11 transcription factor A

1

4

High-throughput

0.479

High

155355

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

1

High-throughput

0.479

High

155374

MTF2
Metal-response element-binding transcription factor 2

1

1

High-throughput

0.479

High

155328

ZN420
Zinc finger protein 420

1

0

High-throughput

0.460

High

155257

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

155258

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

155267

SAP30
Histone deacetylase complex subunit SAP30

1

0

High-throughput

0.458

High

155281

MYBB
Myb-related protein B

1

0

High-throughput

0.458

High

155292

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

155293

H4
Histone H4

1

0

High-throughput

0.458

High

155296

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

155301

CAF1A
Chromatin assembly factor 1 subunit A

1

0

High-throughput

0.458

High

155307

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

155309

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

155313

ARI4B
AT-rich interactive domain-containing protein 4B

1

0

High-throughput

0.458

High

155314

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

155316

LIN9
Protein lin-9 homolog

1

0

High-throughput

0.458

High

155317

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

155318

BCOR
BCL-6 corepressor

1

0

High-throughput

0.458

High

155321

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.458

High

155324

PGBD3
PiggyBac transposable element-derived protein 3

1

0

High-throughput

0.458

High

155327

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.458

High

155331

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

155337

LIN37
Protein lin-37 homolog

1

0

High-throughput

0.458

High

155342

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

155343

PWP2A
PWWP domain-containing protein 2A

1

0

High-throughput

0.458

High

155349

DPY30
Protein dpy-30 homolog

1

0

High-throughput

0.458

High

155351

SP130
Histone deacetylase complex subunit SAP130

1

0

High-throughput

0.458

High

155357

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

155370

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.458

High

95903

E7EQY4
Metastasis-associated protein MTA3

1

8

High-throughput

0.445

High

155290

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.445

High

155295

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.438

High

155274

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.437

High

155275

IGHA2
Immunoglobulin heavy constant alpha 2

1

1

High-throughput

0.437

High

155363

GRHL1
Grainyhead-like protein 1 homolog

1

0

High-throughput

0.426

High

155340

CC136
Coiled-coil domain-containing protein 136

2

0

High-throughput

0.330

High

155286

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

0

High-throughput

0.279

Low

155358

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.279

Low

155284

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

155280

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.249

Low

155361

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low

155367

HMGX4
HMG domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025