Protein: LIN54
Protein lin-54 homolog (CXC domain-containing protein 1)

Gene: LIN54
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q6MZP7

Gene Ontology (top 5):
GO:0001067 - transcription regulatory region nucleic acid binding
GO:0003680 - minor groove of adenine-thymine-rich DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1066353

RBBP4
Histone-binding protein RBBP4

6

3

Small-scale

0.735

High

1236068

LIN37
Protein lin-37 homolog

6

3

Small-scale

0.732

High

1216605

LIN9
Protein lin-9 homolog

4

4

Small-scale

0.699

High

1236066

LMBL2
Lethal(3)malignant brain tumor-like protein 2

4

2

High-throughput

0.697

High

519520

MYBB
Myb-related protein B

4

4

Small-scale

0.691

High

519450

MYBA
Myb-related protein A

3

4

Small-scale

0.675

High

1065670

RBL2
Retinoblastoma-like protein 2

3

5

Small-scale

0.667

High

1197990

LIN52
Protein lin-52 homolog

3

1

Small-scale

0.667

High

610377

PRS6A
26S proteasome regulatory subunit 6A

4

0

High-throughput

0.661

High

1110470

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.628

High

1122885

TFDP2
Transcription factor Dp-2

2

2

Small-scale

0.628

High

1119567

NFYC
Nuclear transcription factor Y subunit gamma

3

0

High-throughput

0.625

High

372304

MYC
Myc proto-oncogene protein

3

0

High-throughput

0.613

High

1156745

E2F4
Transcription factor E2F4

2

4

Small-scale

0.611

High

783711

ZNF76
Zinc finger protein 76

2

1

High-throughput

0.606

High

913884

ZN143
Zinc finger protein 143

2

1

High-throughput

0.606

High

1036885

SP3
Transcription factor Sp3

2

3

High-throughput

0.606

High

1236078

IKZF5
Zinc finger protein Pegasus

2

0

High-throughput

0.602

High

1133470

NFIX
Nuclear factor 1 X-type

2

3

High-throughput

0.601

High

872436

SOX2
Transcription factor SOX-2

2

2

Small-scale

0.584

High

944684

KLF3
Krueppel-like factor 3

2

4

High-throughput

0.584

High

1148599

SF3A2
Splicing factor 3A subunit 2

2

0

High-throughput

0.580

High

1236063

BANP
Protein BANP

2

0

High-throughput

0.580

High

979835

H4
Histone H4

2

0

Small-scale

0.547

High

1061592

FOXM1
Forkhead box protein M1

1

1

High-throughput

0.536

High

1122835

TFDP1
Transcription factor Dp-1

1

2

Small-scale

0.536

High

1236084

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

1099702

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1236080

FOXJ2
Forkhead box protein J2

1

0

High-throughput

0.513

High

442749

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

143053

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

339779

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.479

High

474062

NFIC
Nuclear factor 1 C-type

1

3

High-throughput

0.479

High

520134

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

588931

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

675546

TYY1
Transcriptional repressor protein YY1

1

2

High-throughput

0.479

High

704976

RBL1
Retinoblastoma-like protein 1

1

5

Small-scale

0.479

High

738995

ELF1
ETS-related transcription factor Elf-1

1

4

High-throughput

0.479

High

775860

HNF1B
Hepatocyte nuclear factor 1-beta

1

1

High-throughput

0.479

High

776084

SOX5
Transcription factor SOX-5

1

2

High-throughput

0.479

High

837054

ELK3
ETS domain-containing protein Elk-3

1

4

High-throughput

0.479

High

879191

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

998439

H31
Histone H3.1

1

1

High-throughput

0.479

High

1016950

H33
Histone H3.3

1

1

High-throughput

0.479

High

1087805

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

1096722

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1152699

ELF2
ETS-related transcription factor Elf-2

1

3

High-throughput

0.479

High

1236064

NUP43
Nucleoporin Nup43

1

4

High-throughput

0.479

High

1236065

SP7
Transcription factor Sp7

1

5

High-throughput

0.479

High

1236069

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1236071

FEV
Protein FEV

1

4

High-throughput

0.479

High

1236072

ELF4
ETS-related transcription factor Elf-4

1

4

High-throughput

0.479

High

1236074

KLF16
Krueppel-like factor 16

1

4

High-throughput

0.479

High

1236082

KLF15
Krueppel-like factor 15

1

5

High-throughput

0.479

High

1236086

KLF12
Krueppel-like factor 12

1

4

High-throughput

0.479

High

190957

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

242005

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

414030

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

558206

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

685231

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.458

High

695719

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

714196

PML
Protein PML

1

0

High-throughput

0.458

High

725268

TLX1
T-cell leukemia homeobox protein 1

1

0

High-throughput

0.458

High

768435

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

833970

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

886955

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.458

High

895738

LHX2
LIM/homeobox protein Lhx2

1

0

High-throughput

0.458

High

980848

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1086541

TROP
Trophinin

1

0

High-throughput

0.458

High

1097354

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1236061

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1236062

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1236073

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

1236076

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1236079

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1236081

ZMYM2
Zinc finger MYM-type protein 2

1

0

High-throughput

0.458

High

1236085

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

188304

HDAC3
Histone deacetylase 3

1

1

Small-scale

0.445

High

278368

NCOR1
Nuclear receptor corepressor 1

1

1

Small-scale

0.445

High

667909

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.445

High

1146292

E2F5
Transcription factor E2F5

1

4

Small-scale

0.445

High

1071165

ARL16
ADP-ribosylation factor-like protein 16

1

1

High-throughput

0.437

High

284452

HSBP1
Heat shock factor-binding protein 1

1

0

Small-scale

0.426

High

402778

CYTB
Cystatin-B

1

0

Small-scale

0.426

High

447114

NPM
Nucleophosmin

1

0

Small-scale

0.426

High

650812

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

Small-scale

0.426

High

716437

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.426

High

1105623

GOGA4
Golgin subfamily A member 4

1

0

Small-scale

0.426

High

1236070

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.426

High

1236075

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

0

Small-scale

0.426

High

1236083

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.426

High

212426

SPIT2
Kunitz-type protease inhibitor 2

3

0

High-throughput

0.347

High

418202

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

3

0

High-throughput

0.345

High

1106166

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

2

0

High-throughput

0.328

High

190393

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

505171

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

549615

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

813125

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

1236067

CC74A
Coiled-coil domain-containing protein 74A

1

0

High-throughput

0.279

Low

1236077

GSTO2
Glutathione S-transferase omega-2

1

0

High-throughput

0.279

Low

378119

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

991863

DYLT1
Dynein light chain Tctex-type 1

1

0

High-throughput

0.249

Low

420005

B3A2
Anion exchange protein 2

1

0

Small-scale

0.232

Low

428424

RLA2
Large ribosomal subunit protein P2

1

0

Small-scale

0.232

Low

884119

SRP09
Signal recognition particle 9 kDa protein

1

0

Small-scale

0.232

Low

963522

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

0

Small-scale

0.232

Low

1105693

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

Small-scale

0.232

Low

1140249

IF4H
Eukaryotic translation initiation factor 4H

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025