Protein: TF3C5
General transcription factor 3C polypeptide 5 (TF3C-epsilon) (Transcription factor IIIC 63 kDa subunit) (TFIIIC 63 kDa subunit) (TFIIIC63) (Transcription factor IIIC subunit epsilon)

Gene: TF3C5, GTF3C5
Organism: Homo sapiens
Interactions: 163
UniProt ID: Q9Y5Q8

Gene Ontology (top 5):
GO:0000127 - transcription factor TFIIIC complex
GO:0000995 - RNA polymerase III general transcription initiation factor activity
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0006383 - transcription by RNA polymerase III

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1379899

TF3C6
General transcription factor 3C polypeptide 6

1

0

Small-scale

0.697

High

1491730

TF3C3
General transcription factor 3C polypeptide 3

4

3

Small-scale

0.691

High

644164

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

High-throughput

0.682

High

1461188

TF3C4
General transcription factor 3C polypeptide 4

3

1

Small-scale

0.674

High

920401

PLK1
Serine/threonine-protein kinase PLK1

4

0

High-throughput

0.664

High

1356469

TF3C2
General transcription factor 3C polypeptide 2

4

0

Small-scale

0.648

High

625732

CSK22
Casein kinase II subunit alpha'

2

1

High-throughput

0.628

High

1491729

TF3C5
General transcription factor 3C polypeptide 5

1

1

High-throughput

0.618

High

1114770

CUL3
Cullin-3

2

1

High-throughput

0.611

High

999005

H31
Histone H3.1

2

2

High-throughput

0.584

High

1433873

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

2

2

Small-scale

0.584

High

835782

KPCI
Protein kinase C iota type

2

1

High-throughput

0.571

High

373626

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

935355

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.559

High

223963

TCF21
Transcription factor 21

1

1

High-throughput

0.541

High

221979

FOXS1
Forkhead box protein S1

1

3

High-throughput

0.536

High

937669

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.536

High

998139

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1054824

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.536

High

1091385

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

1112820

CUL1
Cullin-1

1

1

High-throughput

0.536

High

1051345

KPCZ
Protein kinase C zeta type

2

1

High-throughput

0.521

High

587272

ITF2
Transcription factor 4

1

0

High-throughput

0.518

High

578323

ETS2
Protein C-ets-2

1

0

High-throughput

0.513

High

833804

KDM5C
Lysine-specific demethylase 5C

1

0

High-throughput

0.513

High

970202

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1144236

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1145456

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.513

High

1148098

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1163317

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1163954

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1287911

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

1366378

TF3A
Transcription factor IIIA

1

0

High-throughput

0.513

High

1458571

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.513

High

186147

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

951926

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

831724

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

1460267

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

1407779

FOXB1
Forkhead box protein B1

1

4

High-throughput

0.489

High

1420526

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.489

High

1461441

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.489

High

1367695

ESR2
Estrogen receptor beta

1

1

High-throughput

0.484

High

628866

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

1439520

SRA1
Steroid receptor RNA activator 1

1

0

Small-scale

0.480

High

191184

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

260656

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

316224

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

404573

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

487933

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

590144

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

872945

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

881637

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

883748

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

965375

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

1017336

H33
Histone H3.3

1

2

High-throughput

0.479

High

1067883

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

1089080

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1096885

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1129801

MDC1
Mediator of DNA damage checkpoint protein 1

1

1

High-throughput

0.479

High

1130235

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

Small-scale

0.479

High

1257187

PAXI1
PAX-interacting protein 1

1

3

High-throughput

0.479

High

1314503

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1364322

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.479

High

1371363

TF3B
Transcription factor IIIB 90 kDa subunit

1

2

Small-scale

0.479

High

1380294

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

1401475

CIC
Protein capicua homolog

1

2

High-throughput

0.479

High

1414289

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

Small-scale

0.479

High

1430662

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1436590

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

129599

MEN1
Menin

1

0

High-throughput

0.458

High

159934

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

173616

XPO1
Exportin-1

1

0

High-throughput

0.458

High

194412

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

473226

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

551360

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

607273

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

696985

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

766982

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

769628

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

800196

COIL
Coilin

1

0

High-throughput

0.458

High

839421

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

862589

YAP1
Transcriptional coactivator YAP1

1

0

High-throughput

0.458

High

897441

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

905346

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

980620

H4
Histone H4

1

0

High-throughput

0.458

High

995369

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1091657

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.458

High

1100589

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1106399

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

1107382

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1154036

SMAD1
Mothers against decapentaplegic homolog 1

1

0

Small-scale

0.458

High

1155954

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1161781

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

1352871

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1364739

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1390556

CDCA5
Sororin

1

0

High-throughput

0.458

High

1429421

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1435509

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1447509

ANLN
Anillin

1

0

High-throughput

0.458

High

1452496

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1453071

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1454385

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1459468

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

430565

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

530669

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

1085862

TF3C1
General transcription factor 3C polypeptide 1

1

1

Small-scale

0.445

High

1404550

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.445

High

950041

KR103
Keratin-associated protein 10-3

1

1

High-throughput

0.439

High

303005

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.437

High

731743

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.437

High

1130557

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1209850

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1322689

RPTOR
Regulatory-associated protein of mTOR

1

2

Small-scale

0.408

High

1253190

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.407

High

949639

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

243420

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.305

High

1230325

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

1277456

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.299

High

1407144

MDFI
MyoD family inhibitor

1

0

High-throughput

0.299

High

193653

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

0

High-throughput

0.298

High

531186

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.298

High

295661

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

457803

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

549721

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.279

Low

585006

ZNF44
Zinc finger protein 44

1

0

High-throughput

0.279

Low

585835

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

0

High-throughput

0.279

Low

591406

CD44
CD44 antigen

1

0

High-throughput

0.279

Low

1208347

SPXN2
Sperm protein associated with the nucleus on the X chromosome N2

1

0

High-throughput

0.279

Low

1242376

PLBL1
Phospholipase B-like 1

1

0

High-throughput

0.279

Low

1323937

KLH34
Kelch-like protein 34

1

0

High-throughput

0.279

Low

1341357

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.279

Low

1381301

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.279

Low

1394856

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.279

Low

1398215

PPM1M
Protein phosphatase 1M

1

0

High-throughput

0.279

Low

1409628

NIPS1
Protein NipSnap homolog 1

1

0

High-throughput

0.279

Low

1420275

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1437028

ANRA2
Ankyrin repeat family A protein 2

1

0

Small-scale

0.279

Low

1449475

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

1453413

HPBP1
Hsp70-binding protein 1

1

0

High-throughput

0.279

Low

1460709

DNM3L
DNA

1

0

Small-scale

0.261

Low

294591

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

320189

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

412890

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

472374

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

971365

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1024966

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1025972

NDP
Norrin

1

0

Small-scale

0.249

Low

1256280

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1258433

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

1277042

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1327301

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1335114

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1348278

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1363913

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.249

Low

1393883

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1396882

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

1397608

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

1414993

CP250
Centrosome-associated protein CEP250

1

0

High-throughput

0.249

Low

1432737

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.249

Low

1461739

HECD1
E3 ubiquitin-protein ligase HECTD1

1

0

High-throughput

0.249

Low

62625

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

1392760

ZN764
Zinc finger protein 764

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025