Protein: PELI1
E3 ubiquitin-protein ligase pellino homolog 1 (Pellino-1) (EC 2.3.2.27) (Pellino-related intracellular-signaling molecule) (RING-type E3 ubiquitin transferase pellino homolog 1)

Gene: PELI1
Organism: Homo sapiens
Interactions: 70
UniProt ID: Q96FA3

Gene Ontology (top 5):
GO:0001819 - positive regulation of cytokine production
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

905645

IRAK1
Interleukin-1 receptor-associated kinase 1

11

10

Small-scale

0.760

High

1390443

IRAK4
Interleukin-1 receptor-associated kinase 4

9

2

Small-scale

0.756

High

1390448

TRAF6
TNF receptor-associated factor 6

4

3

Small-scale

0.694

High

1103926

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

3

5

Small-scale

0.655

High

179735

MDM4
Protein Mdm4

3

0

Small-scale

0.652

High

957816

UBE2N
Ubiquitin-conjugating enzyme E2 N

3

4

Small-scale

0.646

High

1109649

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

6

Small-scale

0.634

High

1390445

TBK1
Serine/threonine-protein kinase TBK1

2

1

Small-scale

0.611

High

1390440

P63
Tumor protein 63

2

3

High-throughput

0.606

High

508429

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

2

Small-scale

0.602

High

160322

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.580

High

386082

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

0

High-throughput

0.580

High

1152787

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

2

0

High-throughput

0.580

High

1322774

CNTRB
Centrobin

2

0

High-throughput

0.580

High

251797

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

Small-scale

0.578

High

1108034

SQSTM
Sequestosome-1

1

3

Small-scale

0.578

High

1390449

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

2

Small-scale

0.578

High

772517

IRS1
Insulin receptor substrate 1

2

1

High-throughput

0.576

High

363705

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.561

High

1048291

KPCT
Protein kinase C theta type

1

1

Small-scale

0.561

High

832766

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.554

High

1254001

CL17A
C-type lectin domain family 17, member A

2

1

High-throughput

0.553

High

1006619

SRPK2
SRSF protein kinase 2

1

3

High-throughput

0.550

High

1390437

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.550

High

1065994

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.549

High

1151042

PCH2
Pachytene checkpoint protein 2 homolog

1

0

High-throughput

0.549

High

1107104

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

Small-scale

0.537

High

219873

SMAD6
Mothers against decapentaplegic homolog 6

1

2

Small-scale

0.529

High

414395

P53
Cellular tumor antigen p53

1

3

Small-scale

0.527

High

993707

UBC9
SUMO-conjugating enzyme UBC9

1

3

Small-scale

0.527

High

1390439

MYD88
Myeloid differentiation primary response protein MyD88

1

2

Small-scale

0.515

High

1369465

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

167951

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

2

Small-scale

0.501

High

906744

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

957164

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

982283

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.501

High

843859

HD
Huntingtin

1

0

High-throughput

0.493

High

1105713

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.493

High

849078

ZAP70
Tyrosine-protein kinase ZAP-70

1

0

Small-scale

0.480

High

210202

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

11

Small-scale

0.479

High

213995

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

5

Small-scale

0.479

High

280426

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

1

Small-scale

0.479

High

575760

IL1R1
Interleukin-1 receptor type 1

1

1

Small-scale

0.479

High

744484

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

1

Small-scale

0.479

High

879356

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

Small-scale

0.479

High

1008285

PRKDC
DNA-dependent protein kinase catalytic subunit

1

1

Small-scale

0.479

High

1102224

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.479

High

1110879

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.479

High

1390438

CTIP
DNA endonuclease RBBP8

1

1

Small-scale

0.479

High

1390446

ASC
Apoptosis-associated speck-like protein containing a CARD

1

1

Small-scale

0.479

High

262113

NBN
Nibrin

1

0

Small-scale

0.458

High

343009

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

Small-scale

0.458

High

487633

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

559452

XRCC5
X-ray repair cross-complementing protein 5

1

0

Small-scale

0.458

High

591782

H2AX
Histone H2AX

1

0

Small-scale

0.458

High

617724

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

639290

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.458

High

892917

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

920492

DAPK1
Death-associated protein kinase 1

1

0

Small-scale

0.458

High

1088963

TP53B
TP53-binding protein 1

1

0

Small-scale

0.458

High

1113975

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1307141

TCAM1
TIR domain-containing adapter molecule 1

1

0

Small-scale

0.458

High

1369738

RAD50
DNA repair protein RAD50

1

0

Small-scale

0.458

High

431596

AP2A
Transcription factor AP-2-alpha

1

0

High-throughput

0.438

High

1390442

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1390444

SAE2
SUMO-activating enzyme subunit 2

1

0

Small-scale

0.426

High

1009698

NGAL
Neutrophil gelatinase-associated lipocalin

2

0

High-throughput

0.316

High

1390441

RIMS4
Regulating synaptic membrane exocytosis protein 4

2

0

High-throughput

0.316

High

47394

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

1390447

WASC3
WASH complex subunit 3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025