Protein: MARH8
E3 ubiquitin-protein ligase MARCHF8 (EC 2.3.2.27) (Cellular modulator of immune recognition) (c-MIR) (Membrane-associated RING finger protein 8) (Membrane-associated RING-CH protein VIII) (MARCH-VIII) (RING finger protein 178) (RING-type E3 ubiquitin transferase MARCHF8)

Gene: MARH8, MARCHF8
Organism: Homo sapiens
Interactions: 63
UniProt ID: Q5T0T0

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0002250 - adaptive immune response
GO:0002495 - antigen processing and presentation of peptide antigen via MHC class II
GO:0004842 - ubiquitin-protein transferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

209029

CYB5B
Cytochrome b5 type B

2

2

High-throughput

0.606

High

1211662

FA2H
Fatty acid 2-hydroxylase

2

2

High-throughput

0.606

High

957092

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.602

High

970628

UBE2H
Ubiquitin-conjugating enzyme E2 H

2

20

Small-scale

0.602

High

390607

TFR1
Transferrin receptor protein 1

2

2

Small-scale

0.584

High

160282

GOSR2
Golgi SNAP receptor complex member 2

2

0

High-throughput

0.580

High

784967

ARRC
Arrestin-C

2

0

High-throughput

0.580

High

1211664

CGAS
Cyclic GMP-AMP synthase

1

1

Small-scale

0.578

High

1211666

CCD47
PAT complex subunit CCDC47

2

2

High-throughput

0.571

High

485192

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.561

High

965717

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

Small-scale

0.561

High

1211667

FUBP3
Far upstream element-binding protein 3

1

2

Small-scale

0.561

High

1211672

IL1AP
Interleukin-1 receptor accessory protein

1

2

Small-scale

0.561

High

989343

VAMP2
Vesicle-associated membrane protein 2

2

6

High-throughput

0.553

High

1211677

TM14C
Transmembrane protein 14C

2

2

High-throughput

0.553

High

127688

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

6

Small-scale

0.533

High

163313

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

6

Small-scale

0.533

High

508103

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.501

High

906674

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

20

Small-scale

0.501

High

1211660

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

12

Small-scale

0.501

High

467266

MDR1
ATP-dependent translocase ABCB1

1

2

Small-scale

0.479

High

575755

IL1R1
Interleukin-1 receptor type 1

1

3

Small-scale

0.479

High

675050

TNR6
Tumor necrosis factor receptor superfamily member 6

1

6

Small-scale

0.479

High

837296

CD86
T-lymphocyte activation antigen CD86

1

5

Small-scale

0.479

High

900855

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

908018

VAMP7
Vesicle-associated membrane protein 7

1

5

High-throughput

0.479

High

963518

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.479

High

1047573

NOTC2
Neurogenic locus notch homolog protein 2

1

5

High-throughput

0.479

High

1062498

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

1101988

PABP4
Polyadenylate-binding protein 4

1

1

Small-scale

0.479

High

1139447

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.479

High

1211661

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.479

High

1211665

MSPD2
Motile sperm domain-containing protein 2

1

1

High-throughput

0.479

High

1211668

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

High-throughput

0.479

High

1211670

AT131
Endoplasmic reticulum transmembrane helix translocase

1

4

High-throughput

0.479

High

1211671

WDR6
tRNA

1

1

High-throughput

0.479

High

1211675

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

1

High-throughput

0.479

High

1211676

PD1L1
Programmed cell death 1 ligand 1

1

5

Small-scale

0.479

High

367594

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

556135

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

586736

RS2
Small ribosomal subunit protein uS5

1

0

Small-scale

0.458

High

719939

HMOX2
Heme oxygenase 2

1

0

High-throughput

0.458

High

786334

PGM1
Phosphoglucomutase-1

1

0

High-throughput

0.458

High

827810

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

860230

RS9
Small ribosomal subunit protein uS4

1

0

Small-scale

0.458

High

951707

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

1039246

RL6
Large ribosomal subunit protein eL6

1

0

Small-scale

0.458

High

1211669

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.458

High

1211673

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1211674

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

1

0

Small-scale

0.458

High

522679

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

7

High-throughput

0.437

High

620407

NUCL
Nucleolin

1

1

Small-scale

0.437

High

910546

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

Small-scale

0.437

High

914089

HXK2
Hexokinase-2

1

1

Small-scale

0.437

High

1101735

PTK7
Inactive tyrosine-protein kinase 7

1

2

High-throughput

0.437

High

1211663

LSR
Lipolysis-stimulated lipoprotein receptor

1

2

High-throughput

0.437

High

1211678

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.437

High

358704

LDHA
L-lactate dehydrogenase A chain

1

0

Small-scale

0.249

Low

591309

CD44
CD44 antigen

1

0

Small-scale

0.249

Low

1013398

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.249

Low

1016924

H33
Histone H3.3

1

0

Small-scale

0.249

Low

1083515

BST2
Bone marrow stromal antigen 2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025