Protein: DIESL
DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)

Gene: DIESL, TMEM68
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q96MH6

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0016020 - membrane
GO:0019432 - triglyceride biosynthetic process
GO:0046027 - phospholipid:diacylglycerol acyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1398187

RTN4
Reticulon-4

2

1

High-throughput

0.628

High

1316349

AGRG5
Adhesion G-protein coupled receptor G5

2

0

High-throughput

0.602

High

1393191

TM169
Transmembrane protein 169

2

0

High-throughput

0.576

High

1027144

REEP5
Receptor expression-enhancing protein 5

2

1

High-throughput

0.574

High

328980

RTN3
Reticulon-3

1

1

High-throughput

0.536

High

1112447

MTMR3
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR3

1

1

High-throughput

0.536

High

1393433

REEP6
Receptor expression-enhancing protein 6

1

1

High-throughput

0.536

High

1398188

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

1

High-throughput

0.536

High

868012

GLR
Glucagon receptor

1

0

High-throughput

0.513

High

1238363

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.513

High

1243396

TM154
Transmembrane protein 154

1

0

High-throughput

0.513

High

1359347

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

0

High-throughput

0.513

High

1388161

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1398184

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1398189

CLC2D
C-type lectin domain family 2 member D

1

0

High-throughput

0.513

High

349536

TSN15
Tetraspanin-15

1

3

High-throughput

0.489

High

477455

CD63
CD63 antigen

1

3

High-throughput

0.489

High

618412

TSN8
Tetraspanin-8

1

3

High-throughput

0.489

High

622096

CD53
Leukocyte surface antigen CD53

1

3

High-throughput

0.489

High

1339977

OR6T1
Olfactory receptor 6T1

1

1

High-throughput

0.489

High

461824

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468698

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

560485

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

814845

CUX1
Homeobox protein cut-like 1

1

1

High-throughput

0.437

High

170922

CLGN
Calmegin

1

0

High-throughput

0.426

High

1119455

CASP
Protein CASP

1

1

High-throughput

0.407

High

1294757

LYPD6
Ly6/PLAUR domain-containing protein 6

3

0

High-throughput

0.347

High

1159097

C3AR
C3a anaphylatoxin chemotactic receptor

2

0

High-throughput

0.328

High

1398186

PACC1
Proton-activated chloride channel

2

0

High-throughput

0.328

High

469743

GSTA1
Glutathione S-transferase A1

1

0

High-throughput

0.279

Low

1164073

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.279

Low

1203770

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.279

Low

1212286

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.279

Low

1339925

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

1398183

FUND2
FUN14 domain-containing protein 2

1

0

High-throughput

0.279

Low

1398185

TCAL2
Transcription elongation factor A protein-like 2

1

0

High-throughput

0.279

Low

1398190

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

589443

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

1255117

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

379562

IGHM
Immunoglobulin heavy constant mu

1

0

High-throughput

0.232

Low

886120

CXCR3
C-X-C chemokine receptor type 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025