Protein: SGPP1
Sphingosine-1-phosphate phosphatase 1 (SPPase1) (Spp1) (hSPP1) (hSPPase1) (EC 3.1.3.-) (Sphingosine-1-phosphatase 1) (Sphingosine-1-phosphate phosphohydrolase 1) (SPP-1)

Gene: SGPP1
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q9BX95

Gene Ontology (top 5):
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006668 - sphinganine-1-phosphate metabolic process
GO:0006670 - sphingosine metabolic process
GO:0030149 - sphingolipid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

722605

CTR1
High affinity cationic amino acid transporter 1

3

2

High-throughput

0.662

High

1351228

MCLN3
Mucolipin-3

3

0

High-throughput

0.638

High

1416638

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

3

0

High-throughput

0.638

High

1316363

AGRG5
Adhesion G-protein coupled receptor G5

2

1

High-throughput

0.628

High

1416633

S39A8
Metal cation symporter ZIP8

2

1

High-throughput

0.628

High

1042780

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

2

High-throughput

0.611

High

1308960

S22A9
Organic anion transporter 7

3

3

High-throughput

0.604

High

1355928

GDPD5
Glycerophosphodiester phosphodiesterase domain-containing protein 5

2

0

High-throughput

0.602

High

1390874

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.602

High

1416634

YIPF3
Protein YIPF3

2

0

High-throughput

0.602

High

1416637

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.602

High

1312240

MIRO2
Mitochondrial Rho GTPase 2

2

2

High-throughput

0.574

High

182758

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

351956

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.536

High

406927

MAS
Proto-oncogene Mas

1

2

High-throughput

0.536

High

833863

P2RY2
P2Y purinoceptor 2

1

2

High-throughput

0.536

High

854577

S15A1
Solute carrier family 15 member 1

1

1

High-throughput

0.536

High

868015

GLR
Glucagon receptor

1

2

High-throughput

0.536

High

880196

PTH2R
Parathyroid hormone 2 receptor

1

2

High-throughput

0.536

High

1291766

S22AG
Solute carrier family 22 member 16

1

3

High-throughput

0.536

High

1407297

CML1
Chemerin-like receptor 1

1

2

High-throughput

0.536

High

1416635

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.536

High

820576

GPV
Platelet glycoprotein V

1

0

High-throughput

0.513

High

1212298

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.513

High

1254079

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.513

High

1372384

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

0

High-throughput

0.513

High

508552

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

1416636

RHOF
Rho-related GTP-binding protein RhoF

1

1

High-throughput

0.479

High

955545

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.458

High

1101305

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.458

High

1101653

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.445

High

1246109

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

1

High-throughput

0.445

High

1361300

CTR3
Cationic amino acid transporter 3

1

2

High-throughput

0.445

High

1363784

YLAT2
Y+L amino acid transporter 2

1

2

High-throughput

0.445

High

1366211

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.445

High

302083

SEGN
Secretagogin

3

0

High-throughput

0.347

High

1005554

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

0

High-throughput

0.347

High

469541

SYPH
Synaptophysin

2

0

High-throughput

0.328

High

219826

CHSTA
Carbohydrate sulfotransferase 10

2

0

High-throughput

0.318

High

1010100

DLK1
Protein delta homolog 1

2

0

High-throughput

0.318

High

655916

TBG1
Tubulin gamma-1 chain

1

0

High-throughput

0.279

Low

1336524

LRN4L
LRRN4 C-terminal-like protein

1

0

High-throughput

0.279

Low

1392455

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low

1393072

CREL1
Protein disulfide isomerase CRELD1

1

0

High-throughput

0.279

Low

1416619

TM2D2
TM2 domain-containing protein 2

1

0

High-throughput

0.279

Low

1416639

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

294284

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1045721

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1255374

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1334866

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1280810

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025