Protein: LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1)

Gene: LRRK1
Organism: Homo sapiens
Interactions: 117
UniProt ID: Q38SD2

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

338504

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.861

High

337488

ABL1
Tyrosine-protein kinase ABL1

3

6

High-throughput

0.857

High

1105457

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

2

20

Small-scale

0.836

High

861776

PLK1
Serine/threonine-protein kinase PLK1

2

9

Small-scale

0.834

High

1105460

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

20

Small-scale

0.789

High

431914

HS90A
Heat shock protein HSP 90-alpha

2

10

Small-scale

0.789

High

161666

GAK
Cyclin-G-associated kinase

2

8

High-throughput

0.778

High

434210

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

2

20

High-throughput

0.778

High

601521

FGFR2
Fibroblast growth factor receptor 2

2

8

High-throughput

0.778

High

665481

EPHA8
Ephrin type-A receptor 8

2

16

High-throughput

0.778

High

729289

VGFR3
Vascular endothelial growth factor receptor 3

2

5

High-throughput

0.778

High

788967

MATK
Megakaryocyte-associated tyrosine-protein kinase

2

7

High-throughput

0.778

High

1105480

NEK1
Serine/threonine-protein kinase Nek1

2

14

High-throughput

0.778

High

1105483

BAG1
BAG family molecular chaperone regulator 1

2

2

High-throughput

0.778

High

1105492

PAK6
Serine/threonine-protein kinase PAK 6

2

9

High-throughput

0.778

High

1105497

BORG2
Cdc42 effector protein 3

2

2

High-throughput

0.778

High

438225

HS90B
Heat shock protein HSP 90-beta

2

10

High-throughput

0.776

High

924610

GRB2
Growth factor receptor-bound protein 2

5

6

High-throughput

0.703

High

1105498

BAG5
BAG family molecular chaperone regulator 5

3

4

Small-scale

0.674

High

666124

SHC1
SHC-transforming protein 1

4

5

High-throughput

0.666

High

331022

PAK4
Serine/threonine-protein kinase PAK 4

1

8

High-throughput

0.665

High

862048

DAPK1
Death-associated protein kinase 1

1

6

Small-scale

0.665

High

1036625

SQSTM
Sequestosome-1

1

4

Small-scale

0.665

High

160927

RAB7L
Ras-related protein Rab-7L1

1

16

High-throughput

0.647

High

414943

CDK1
Cyclin-dependent kinase 1

1

9

Small-scale

0.647

High

788997

TEC
Tyrosine-protein kinase Tec

1

20

High-throughput

0.647

High

1105467

FXL14
F-box/LRR-repeat protein 14

1

20

High-throughput

0.647

High

176452

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

3

High-throughput

0.618

High

681469

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.618

High

992478

SOS1
Son of sevenless homolog 1

1

3

High-throughput

0.618

High

992510

SOS2
Son of sevenless homolog 2

1

2

High-throughput

0.618

High

1034875

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.618

High

1073340

RSU1
Ras suppressor protein 1

1

19

High-throughput

0.618

High

1082790

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.618

High

1105475

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

10

High-throughput

0.618

High

1105499

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

1

High-throughput

0.618

High

1105501

GAB2
GRB2-associated-binding protein 2

1

2

High-throughput

0.618

High

943252

TCPB
T-complex protein 1 subunit beta

2

10

High-throughput

0.611

High

306583

SCEL
Sciellin

2

1

High-throughput

0.602

High

313294

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

1

High-throughput

0.602

High

323798

BAG2
BAG family molecular chaperone regulator 2

2

4

High-throughput

0.602

High

324432

BAG3
BAG family molecular chaperone regulator 3

2

4

High-throughput

0.602

High

580428

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

2

4

High-throughput

0.602

High

671459

ECHM
Enoyl-CoA hydratase, mitochondrial

2

5

High-throughput

0.602

High

1027610

CBLB
E3 ubiquitin-protein ligase CBL-B

2

4

High-throughput

0.602

High

1105458

PDCD4
Programmed cell death protein 4

2

4

High-throughput

0.602

High

1105459

ODFP2
Outer dense fiber protein 2

2

6

High-throughput

0.602

High

1105478

ITCH
E3 ubiquitin-protein ligase Itchy homolog

2

6

High-throughput

0.602

High

1105484

TCF25
Ribosome quality control complex subunit TCF25

2

1

High-throughput

0.602

High

1105487

FOXP1
Forkhead box protein P1

2

2

High-throughput

0.602

High

1105494

CWC15
Spliceosome-associated protein CWC15 homolog

2

1

High-throughput

0.602

High

1105500

CHIP
E3 ubiquitin-protein ligase CHIP

2

9

High-throughput

0.602

High

1105503

SNX9
Sorting nexin-9

2

4

High-throughput

0.602

High

504171

HSP7C
Heat shock cognate 71 kDa protein

2

7

Small-scale

0.601

High

1105481

CK5P2
CDK5 regulatory subunit-associated protein 2

1

8

Small-scale

0.589

High

886006

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

2

0

High-throughput

0.577

High

1045432

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

9

High-throughput

0.575

High

134301

CCL21
C-C motif chemokine 21

2

1

High-throughput

0.550

High

198778

CMIP4
Ciliary microtubule inner protein 4

2

1

High-throughput

0.550

High

393790

SCG1
Secretogranin-1

2

5

High-throughput

0.550

High

1048838

VGLL4
Transcription cofactor vestigial-like protein 4

2

2

High-throughput

0.550

High

1105473

CKAP2
Cytoskeleton-associated protein 2

2

1

High-throughput

0.550

High

1105490

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.550

High

506598

BCR
Breakpoint cluster region protein

1

5

High-throughput

0.536

High

573283

TCPA
T-complex protein 1 subunit alpha

1

8

High-throughput

0.536

High

770860

TCPZ
T-complex protein 1 subunit zeta

1

8

High-throughput

0.536

High

821234

TCPE
T-complex protein 1 subunit epsilon

1

10

High-throughput

0.536

High

826684

TCPG
T-complex protein 1 subunit gamma

1

10

High-throughput

0.536

High

842889

TCPQ
T-complex protein 1 subunit theta

1

12

High-throughput

0.536

High

843220

TCPD
T-complex protein 1 subunit delta

1

8

High-throughput

0.536

High

858630

PPP5
Serine/threonine-protein phosphatase 5

1

8

High-throughput

0.536

High

1105482

TCPH
T-complex protein 1 subunit eta

1

10

High-throughput

0.536

High

1105489

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

1105493

SHLB2
Endophilin-B2

1

6

High-throughput

0.536

High

1105502

SGT1
Protein SGT1 homolog

1

10

High-throughput

0.536

High

396747

S10A8
Protein S100-A8

1

5

High-throughput

0.515

High

1105464

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.515

High

308763

KI20A
Kinesin-like protein KIF20A

1

7

High-throughput

0.501

High

473905

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

1

High-throughput

0.501

High

1105486

MTG1
Mitochondrial ribosome-associated GTPase 1

1

3

High-throughput

0.501

High

1105491

SH22A
SH2 domain-containing protein 2A

1

5

High-throughput

0.501

High

1105496

TR112
Multifunctional methyltransferase subunit TRM112-like protein

1

1

High-throughput

0.501

High

419208

ITAV
Integrin alpha-V

1

0

High-throughput

0.493

High

1105465

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

7

High-throughput

0.489

High

1105472

CPLX3
Complexin-3

1

0

High-throughput

0.480

High

808148

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

6

High-throughput

0.479

High

876807

NP1L1
Nucleosome assembly protein 1-like 1

1

5

High-throughput

0.479

High

903966

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

12

High-throughput

0.479

High

985965

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

2

High-throughput

0.479

High

1041695

CUL3
Cullin-3

1

5

Small-scale

0.479

High

1105474

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

3

High-throughput

0.479

High

901579

LYSC
Lysozyme C

1

1

High-throughput

0.470

High

897528

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

1105495

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.458

High

1105462

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

1

High-throughput

0.457

High

1105469

F184A
Protein FAM184A

1

8

High-throughput

0.457

High

1105470

ENKUR
Enkurin

1

1

High-throughput

0.457

High

1105488

LMA1L
Protein ERGIC-53-like

1

1

High-throughput

0.457

High

400322

RLA1
Large ribosomal subunit protein P1

1

1

High-throughput

0.445

High

428238

TBB5
Tubulin beta chain

1

9

High-throughput

0.445

High

933832

TBB4B
Tubulin beta-4B chain

1

9

High-throughput

0.445

High

963342

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

7

High-throughput

0.445

High

749555

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

1105463

DOK3
Docking protein 3

1

2

High-throughput

0.437

High

173223

VGF
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1

1

1

High-throughput

0.407

High

211590

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.407

High

1084958

DREB
Drebrin

1

3

High-throughput

0.407

High

1105466

CLVS1
Clavesin-1

2

0

High-throughput

0.314

High

1105471

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

2

0

High-throughput

0.314

High

1105476

SNX21
Sorting nexin-21

2

0

High-throughput

0.314

High

1105485

TIRR
Tudor-interacting repair regulator protein

2

0

High-throughput

0.314

High

1105461

SKT
Sickle tail protein homolog

1

0

High-throughput

0.261

Low

1105477

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.261

Low

49066

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

1105468

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.249

Low

1105479

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024