Protein: DNM3L
DNA (cytosine-5)-methyltransferase 3-like

Gene: DNM3L, DNMT3L
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9UJW3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000792 - heterochromatin
GO:0000794 - condensed nuclear chromosome
GO:0001890 - placenta development
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1356100

DNM3A
DNA

7

8

Small-scale

0.968

High

1353938

DNM3B
DNA

5

8

Small-scale

0.924

High

1038796

HDAC1
Histone deacetylase 1

2

4

Small-scale

0.639

High

898217

MAX
Protein max

1

3

Small-scale

0.561

High

978929

TF65
Transcription factor p65

1

1

Small-scale

0.561

High

1081438

E2F4
Transcription factor E2F4

1

4

Small-scale

0.561

High

641597

PAX6
Paired box protein Pax-6

1

0

Small-scale

0.537

High

1345215

PHP14
14 kDa phosphohistidine phosphatase

1

0

High-throughput

0.518

High

914679

ERR3
Estrogen-related receptor gamma

1

6

Small-scale

0.512

High

135301

E2F3
Transcription factor E2F3

1

4

Small-scale

0.501

High

198803

HXC11
Homeobox protein Hox-C11

1

3

Small-scale

0.501

High

238473

MAFK
Transcription factor MafK

1

1

Small-scale

0.501

High

265729

E2F6
Transcription factor E2F6

1

4

Small-scale

0.501

High

265883

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

7

Small-scale

0.501

High

330434

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

4

Small-scale

0.501

High

345573

FOS
Protein c-Fos

1

10

Small-scale

0.501

High

370666

ESR1
Estrogen receptor

1

7

Small-scale

0.501

High

377789

GCR
Glucocorticoid receptor

1

7

Small-scale

0.501

High

402599

JUN
Transcription factor Jun

1

7

Small-scale

0.501

High

505308

EGR2
E3 SUMO-protein ligase EGR2

1

3

Small-scale

0.501

High

547860

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

7

Small-scale

0.501

High

548271

FOSL1
Fos-related antigen 1

1

10

Small-scale

0.501

High

548341

FOSL2
Fos-related antigen 2

1

7

Small-scale

0.501

High

554530

GATA1
Erythroid transcription factor

1

2

Small-scale

0.501

High

556998

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

Small-scale

0.501

High

566799

JUNB
Transcription factor JunB

1

7

Small-scale

0.501

High

575620

EGR1
Early growth response protein 1

1

3

Small-scale

0.501

High

579163

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

5

Small-scale

0.501

High

579234

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

8

Small-scale

0.501

High

587204

RXRA
Retinoic acid receptor RXR-alpha

1

6

Small-scale

0.501

High

587744

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.501

High

595647

HXA5
Homeobox protein Hox-A5

1

2

Small-scale

0.501

High

848156

MECP2
Methyl-CpG-binding protein 2

1

3

Small-scale

0.501

High

862640

FOSB
Protein FosB

1

9

Small-scale

0.501

High

874400

NR1H2
Oxysterols receptor LXR-beta

1

6

Small-scale

0.501

High

899131

HAND2
Heart- and neural crest derivatives-expressed protein 2

1

4

Small-scale

0.501

High

918106

H4
Histone H4

1

1

Small-scale

0.501

High

950318

SMAD3
Mothers against decapentaplegic homolog 3

1

2

Small-scale

0.501

High

952687

H33
Histone H3.3

1

6

Small-scale

0.501

High

968803

MEF2A
Myocyte-specific enhancer factor 2A

1

1

Small-scale

0.501

High

974414

CREM
cAMP-responsive element modulator

1

4

Small-scale

0.501

High

983533

EGR4
Early growth response protein 4

1

3

Small-scale

0.501

High

1035625

SMAD4
Mothers against decapentaplegic homolog 4

1

2

Small-scale

0.501

High

1055262

HNF4G
Hepatocyte nuclear factor 4-gamma

1

5

Small-scale

0.501

High

1059601

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.501

High

1061336

NR1I3
Nuclear receptor subfamily 1 group I member 3

1

7

Small-scale

0.501

High

1073362

NR6A1
Nuclear receptor subfamily 6 group A member 1

1

7

Small-scale

0.501

High

1078774

SMAD1
Mothers against decapentaplegic homolog 1

1

2

Small-scale

0.501

High

1085138

NFIL3
Nuclear factor interleukin-3-regulated protein

1

3

Small-scale

0.501

High

1087130

H2A2C
Histone H2A type 2-C

1

2

Small-scale

0.501

High

1087466

H2B2E
Histone H2B type 2-E

1

1

Small-scale

0.501

High

1174681

H32
Histone H3.2

1

6

Small-scale

0.501

High

1269880

ESR2
Estrogen receptor beta

1

7

Small-scale

0.501

High

1273360

DLX4
Homeobox protein DLX-4

1

3

Small-scale

0.501

High

1305338

CDX2
Homeobox protein CDX-2

1

3

Small-scale

0.501

High

1356096

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

9

Small-scale

0.501

High

215056

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.486

High

836074

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

206660

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

Small-scale

0.480

High

236481

CRBL2
cAMP-responsive element-binding protein-like 2

1

0

Small-scale

0.480

High

387690

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

542083

ETS1
Protein C-ets-1

1

0

Small-scale

0.480

High

579303

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

Small-scale

0.480

High

632943

TYY1
Transcriptional repressor protein YY1

1

0

Small-scale

0.480

High

727199

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.480

High

780993

ID1
DNA-binding protein inhibitor ID-1

1

0

Small-scale

0.480

High

839841

LHX2
LIM/homeobox protein Lhx2

1

0

Small-scale

0.480

High

942277

GTF2I
General transcription factor II-I

1

0

Small-scale

0.480

High

966212

NC2B
Protein Dr1

1

0

Small-scale

0.480

High

993642

TLE5
TLE family member 5

1

0

Small-scale

0.480

High

1046808

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.480

High

1199147

LDB1
LIM domain-binding protein 1

1

0

Small-scale

0.480

High

1329404

GO45
Golgin-45

1

0

Small-scale

0.480

High

1354083

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.480

High

1356095

DMTF1
Cyclin-D-binding Myb-like transcription factor 1

1

0

Small-scale

0.480

High

1356097

KLF12
Krueppel-like factor 12

1

0

Small-scale

0.480

High

1356099

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

0

Small-scale

0.480

High

1089467

Q17RL8
HCG2004980, isoform CRA_e

1

1

High-throughput

0.470

High

1071529

E2F5
Transcription factor E2F5

1

4

Small-scale

0.457

High

1176210

PDZD4
PDZ domain-containing protein 4

1

1

High-throughput

0.439

High

1355257

RLP24
Probable ribosome biogenesis protein RLP24

4

0

High-throughput

0.368

High

876210

PAR2
Proteinase-activated receptor 2

1

0

Small-scale

0.261

Low

1356098

TF3C5
General transcription factor 3C polypeptide 5

1

0

Small-scale

0.261

Low


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Last updated: 15 Jul 2024