Protein: ASC
Apoptosis-associated speck-like protein containing a CARD (hASC) (Caspase recruitment domain-containing protein 5) (PYD and CARD domain-containing protein) (Target of methylation-induced silencing 1)

Gene: ASC, PYCARD
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9ULZ3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001773 - myeloid dendritic cell activation
GO:0002020 - protease binding
GO:0002218 - activation of innate immune response
GO:0002221 - pattern recognition receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1299043

NLRP3
NACHT, LRR and PYD domains-containing protein 3

23

18

Small-scale

0.987

High

667498

CASP1
Caspase-1

13

16

Small-scale

0.978

High

1357160

ASC
Apoptosis-associated speck-like protein containing a CARD

11

18

Small-scale

0.977

High

157093

AIM2
Interferon-inducible protein AIM2

6

2

Small-scale

0.956

High

183340

MEFV
Pyrin

6

10

Small-scale

0.954

High

1343007

NLRC4
NLR family CARD domain-containing protein 4

6

20

Small-scale

0.931

High

1263335

PYDC1
Pyrin domain-containing protein 1

4

17

Small-scale

0.879

High

1086034

IF16
Gamma-interferon-inducible protein 16

3

2

Small-scale

0.827

High

1318562

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

19

Small-scale

0.789

High

1347596

NALP2
NACHT, LRR and PYD domains-containing protein 2

2

18

Small-scale

0.776

High

992053

BAX
Apoptosis regulator BAX

1

2

Small-scale

0.696

High

1059399

CASP8
Caspase-8

5

16

Small-scale

0.695

High

1036996

SQSTM
Sequestosome-1

4

3

Small-scale

0.686

High

1122747

PYDC2
Pyrin domain-containing protein 2

1

17

Small-scale

0.683

High

1038335

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

1

High-throughput

0.665

High

177732

BIRC5
Baculoviral IAP repeat-containing protein 5

2

1

High-throughput

0.628

High

1041500

CUL2
Cullin-2

2

7

High-throughput

0.628

High

201833

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

1

Small-scale

0.618

High

886386

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

19

Small-scale

0.618

High

1202839

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

17

Small-scale

0.618

High

883085

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

2

0

High-throughput

0.602

High

1300124

CDK15
Cyclin-dependent kinase 15

2

0

High-throughput

0.602

High

1319191

ZY11B
Protein zyg-11 homolog B

2

0

High-throughput

0.602

High

1357166

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.602

High

796674

KSYK
Tyrosine-protein kinase SYK

1

6

Small-scale

0.586

High

498375

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.582

High

1174171

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

2

Small-scale

0.561

High

1295679

ZFP91
E3 ubiquitin-protein ligase ZFP91

2

0

Small-scale

0.559

High

158566

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

11

Small-scale

0.554

High

167630

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

11

Small-scale

0.554

High

1357167

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.554

High

130120

EXOC5
Exocyst complex component 5

1

0

High-throughput

0.549

High

330294

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.546

High

1329075

CARD9
Caspase recruitment domain-containing protein 9

1

0

Small-scale

0.546

High

117861

MYO1C
Unconventional myosin-Ic

1

1

Small-scale

0.536

High

198484

KLK10
Kallikrein-10

1

1

High-throughput

0.536

High

207846

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

2

Small-scale

0.536

High

669072

PML
Protein PML

1

8

Small-scale

0.536

High

686777

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

1054226

BECN1
Beclin-1

1

8

Small-scale

0.536

High

1233087

FSTL5
Follistatin-related protein 5

1

1

Small-scale

0.536

High

1315335

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

2

Small-scale

0.536

High

1357164

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

321950

RIGI
Antiviral innate immune response receptor RIG-I

1

3

Small-scale

0.515

High

1026243

PAK1
Serine/threonine-protein kinase PAK 1

1

1

High-throughput

0.515

High

1186105

NLRC3
NLR family CARD domain-containing protein 3

1

17

Small-scale

0.515

High

134316

CCL21
C-C motif chemokine 21

1

0

High-throughput

0.513

High

175593

INP4B
Inositol polyphosphate 4-phosphatase type II

1

0

Small-scale

0.513

High

565988

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

708543

MCM4
DNA replication licensing factor MCM4

1

0

Small-scale

0.513

High

770212

IL6RB
Interleukin-6 receptor subunit beta

1

0

Small-scale

0.513

High

836800

DNLI3
DNA ligase 3

1

0

Small-scale

0.513

High

882835

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

884810

NU107
Nuclear pore complex protein Nup107

1

0

Small-scale

0.513

High

932072

TPM4
Tropomyosin alpha-4 chain

1

0

Small-scale

0.513

High

946672

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.513

High

958791

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1046390

BMPR2
Bone morphogenetic protein receptor type-2

1

0

Small-scale

0.513

High

1222449

DRC7
Dynein regulatory complex subunit 7

1

0

Small-scale

0.513

High

1241454

NF2IP
NFATC2-interacting protein

1

0

High-throughput

0.513

High

1307311

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.513

High

1344700

TSH2
Teashirt homolog 2

1

0

Small-scale

0.513

High

1349572

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.513

High

1357162

CP131
Centrosomal protein of 131 kDa

1

0

Small-scale

0.513

High

1357165

MAN1
Inner nuclear membrane protein Man1

1

1

Small-scale

0.489

High

49670

IRGM
Immunity-related GTPase family M protein

1

1

Small-scale

0.479

High

506485

RALB
Ras-related protein Ral-B

1

1

Small-scale

0.479

High

749953

BRCA1
Breast cancer type 1 susceptibility protein

1

6

Small-scale

0.479

High

1024786

TRAF3
TNF receptor-associated factor 3

1

9

Small-scale

0.479

High

1030016

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1085717

HIF1A
Hypoxia-inducible factor 1-alpha

1

1

Small-scale

0.479

High

1255614

NEK7
Serine/threonine-protein kinase Nek7

1

4

Small-scale

0.479

High

1269919

ESR2
Estrogen receptor beta

1

2

Small-scale

0.479

High

1291028

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

1

Small-scale

0.479

High

1330668

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

6

Small-scale

0.479

High

1357161

APC10
Anaphase-promoting complex subunit 10

1

1

Small-scale

0.479

High

387729

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

312676

ARI2
E3 ubiquitin-protein ligase ARIH2

1

4

Small-scale

0.445

High

1354528

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

1

Small-scale

0.445

High

1357168

NEMO
NF-kappa-B essential modulator

1

1

Small-scale

0.445

High

353020

IL1B
Interleukin-1 beta

1

3

Small-scale

0.428

High

303732

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

957120

ENTK
Enteropeptidase

1

0

Small-scale

0.279

Low

1104031

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1239452

F184A
Protein FAM184A

1

0

Small-scale

0.279

Low

1243326

ARMC2
Armadillo repeat-containing protein 2

1

0

Small-scale

0.279

Low

1281764

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.279

Low

1347692

DJC28
DnaJ homolog subfamily C member 28

1

0

Small-scale

0.279

Low

1357163

POK19
Endogenous retrovirus group K member 19 Pol protein

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024