Protein: ABCD4
Lysosomal cobalamin transporter ABCD4 (EC 7.6.2.8) (ATP-binding cassette sub-family D member 4) (PMP70-related protein) (P70R) (Peroxisomal membrane protein 1-like) (PXMP1-L) (Peroxisomal membrane protein 69) (PMP69)

Gene: ABCD4
Organism: Homo sapiens
Interactions: 62
UniProt ID: O14678

Gene Ontology (top 5):
GO:0005324 - long-chain fatty acid transmembrane transporter activity
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0005777 - peroxisome
GO:0005778 - peroxisomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161112

ABCD4
Lysosomal cobalamin transporter ABCD4

2

16

Small-scale

0.737

High

161154

ABCA2
ATP-binding cassette sub-family A member 2

1

1

High-throughput

0.691

High

142119

NPT3
Sodium-dependent phosphate transport protein 3

2

2

High-throughput

0.628

High

161126

FSHR
Follicle-stimulating hormone receptor

2

6

High-throughput

0.628

High

60687

F234B
Protein FAM234B

2

0

High-throughput

0.602

High

161130

CD83
CD83 antigen

1

0

High-throughput

0.578

High

161160

LMBD1
Lysosomal cobalamin transport escort protein LMBD1

2

0

Small-scale

0.576

High

161168

PCDA3
Protocadherin alpha-3

2

6

High-throughput

0.574

High

161121

PGFRB
Platelet-derived growth factor receptor beta

1

1

High-throughput

0.536

High

161124

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

8

High-throughput

0.536

High

161125

KCNA5
Potassium voltage-gated channel subfamily A member 5

1

8

High-throughput

0.536

High

161131

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

5

High-throughput

0.536

High

161132

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

8

High-throughput

0.536

High

161133

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

3

High-throughput

0.536

High

161137

PTHD3
Patched domain-containing protein 3

1

6

High-throughput

0.536

High

161146

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.536

High

161155

TTYH1
Protein tweety homolog 1

1

5

High-throughput

0.536

High

161159

TLR9
Toll-like receptor 9

1

1

High-throughput

0.536

High

161123

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.518

High

161120

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

High-throughput

0.515

High

161129

EREP3
Protein ENTREP3

1

0

High-throughput

0.513

High

161142

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.513

High

161151

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

161115

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.489

High

161127

V1BR
Vasopressin V1b receptor

1

3

High-throughput

0.489

High

161128

FCGRN
IgG receptor FcRn large subunit p51

1

7

High-throughput

0.489

High

161138

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

1

High-throughput

0.489

High

161139

TTMP
TPA-induced transmembrane protein

1

4

High-throughput

0.489

High

161156

RXFP1
Relaxin receptor 1

1

4

High-throughput

0.489

High

161158

KCMB3
Calcium-activated potassium channel subunit beta-3

1

2

High-throughput

0.489

High

161162

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

6

High-throughput

0.489

High

161166

PCDGL
Protocadherin gamma-C4

1

8

High-throughput

0.489

High

161136

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.464

High

161119

GCR
Glucocorticoid receptor

1

6

High-throughput

0.445

High

161134

TRDN
Triadin

1

7

High-throughput

0.445

High

161153

TMM59
Transmembrane protein 59

1

1

High-throughput

0.445

High

161161

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

3

High-throughput

0.445

High

161164

S27A6
Long-chain fatty acid transport protein 6

1

3

High-throughput

0.445

High

161150

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.438

High

161141

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

161113

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.426

High

161140

TM214
Transmembrane protein 214

1

0

High-throughput

0.426

High

161143

FRMD5
FERM domain-containing protein 5

1

0

High-throughput

0.426

High

161152

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.426

High

161157

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

161165

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.426

High

161117

MICA2
[F-actin]-monooxygenase MICAL2

1

1

High-throughput

0.407

High

161144

STX12
Syntaxin-12

1

1

High-throughput

0.407

High

161163

PLAP
Phospholipase A-2-activating protein

1

3

High-throughput

0.407

High

161167

PCDG5
Protocadherin gamma-A5

1

7

High-throughput

0.407

High

161135

PEA15
Astrocytic phosphoprotein PEA-15

1

0

High-throughput

0.282

High

127610

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

161122

CD79A
B-cell antigen receptor complex-associated protein alpha chain

1

0

High-throughput

0.279

Low

161145

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

161169

PUS1
Pseudouridylate synthase 1 homolog

1

0

High-throughput

0.279

Low

161116

S14L2
SEC14-like protein 2

1

0

High-throughput

0.249

Low

161114

LEU1
Leukemia-associated protein 1

1

0

High-throughput

0.238

Low

161118

NFASC
Neurofascin

1

0

High-throughput

0.232

Low

161147

CCNY
Cyclin-Y

1

0

High-throughput

0.232

Low

161148

RCBT1
RCC1 and BTB domain-containing protein 1

1

0

High-throughput

0.232

Low

161149

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025