Protein: PUS1
Pseudouridylate synthase 1 homolog (EC 5.4.99.-) (tRNA pseudouridine synthase 1) (EC 5.4.99.12) (tRNA pseudouridine(38-40) synthase) (tRNA pseudouridylate synthase I) (tRNA-uridine isomerase I)

Gene: PUS1
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q9Y606

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002153 - steroid receptor RNA activator RNA binding
GO:0003682 - chromatin binding
GO:0003713 - transcription coactivator activity
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1452018

THUM1
THUMP domain-containing protein 1

3

1

High-throughput

0.667

High

1203467

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

1414910

THUM3
tRNA

3

0

High-throughput

0.634

High

882972

EFTU
Elongation factor Tu, mitochondrial

2

1

High-throughput

0.611

High

914810

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

852093

EFTS
Elongation factor Ts, mitochondrial

2

0

High-throughput

0.585

High

1433769

MTG2
Mitochondrial ribosome-associated GTPase 2

2

0

High-throughput

0.585

High

243429

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

533111

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.536

High

1118799

KLF5
Krueppel-like factor 5

1

1

High-throughput

0.536

High

1123497

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

187224

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

225226

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

275425

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

278783

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.513

High

282996

FRAT2
GSK-3-binding protein FRAT2

1

0

High-throughput

0.513

High

425980

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

622311

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.513

High

665299

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.513

High

690578

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

716756

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.513

High

842257

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

869268

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

946546

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

1012295

RT11
Small ribosomal subunit protein uS11m

1

0

High-throughput

0.513

High

1242657

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

1275873

RM21
Large ribosomal subunit protein bL21m

1

0

High-throughput

0.513

High

1310566

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1325223

ZN664
Zinc finger protein 664

1

0

High-throughput

0.513

High

1389040

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

1395791

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1430321

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1438827

HES4
Transcription factor HES-4

1

0

High-throughput

0.513

High

1450438

EKI2
Ethanolamine kinase 2

1

0

High-throughput

0.513

High

1459997

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

1460235

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

1491014

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1491350

KIF3A
Kinesin-like protein KIF3A

1

0

High-throughput

0.513

High

1491787

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

373636

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

406856

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

696989

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

769634

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

856444

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

879677

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

955798

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.479

High

962682

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1036031

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1117893

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1151952

RHOH
Rho-related GTP-binding protein RhoH

1

2

High-throughput

0.479

High

1207193

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1312315

MIRO2
Mitochondrial Rho GTPase 2

1

4

High-throughput

0.479

High

1326400

NIN
Ninein

1

1

High-throughput

0.479

High

1388325

RRFM
Ribosome-recycling factor, mitochondrial

1

1

High-throughput

0.479

High

1446469

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

1450484

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

129603

MEN1
Menin

1

0

High-throughput

0.458

High

279995

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

364097

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

471349

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519279

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

774735

BASI
Basigin

1

0

High-throughput

0.458

High

829031

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

831731

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

842055

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

941997

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

971370

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

999007

H31
Histone H3.1

1

0

High-throughput

0.458

High

1048777

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1058383

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1107384

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1161885

DUS5
Dual specificity protein phosphatase 5

1

0

High-throughput

0.458

High

1234585

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1256290

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1277050

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1397134

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

1407981

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

1434359

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1435850

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1436157

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1436592

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1451371

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1453990

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1459481

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1461025

FBW1B
F-box/WD repeat-containing protein 11

1

0

High-throughput

0.458

High

653685

HEMH
Ferrochelatase, mitochondrial

1

1

High-throughput

0.445

High

126897

RHOD
Rho-related GTP-binding protein RhoD

1

4

High-throughput

0.437

High

1433603

RHOJ
Rho-related GTP-binding protein RhoJ

1

2

High-throughput

0.437

High

1438273

RHOF
Rho-related GTP-binding protein RhoF

1

3

High-throughput

0.437

High

1446882

TRPV5
Transient receptor potential cation channel subfamily V member 5

3

0

High-throughput

0.347

High

161169

ABCD4
Lysosomal cobalamin transporter ABCD4

1

0

High-throughput

0.279

Low

1324964

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

0

High-throughput

0.279

Low

1356957

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.279

Low

1491586

PCDBB
Protocadherin beta-11

1

0

High-throughput

0.279

Low

1491786

EMIL1
EMILIN-1

1

0

High-throughput

0.279

Low

164487

NRP1
Neuropilin-1

1

0

High-throughput

0.249

Low

210621

DC1L2
Cytoplasmic dynein 1 light intermediate chain 2

1

0

High-throughput

0.249

Low

1418560

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

1448865

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.249

Low

467044

DAF
Complement decay-accelerating factor

1

0

High-throughput

0.232

Low

1447622

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025