Protein: UBP43
Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.4.19.12) (Deubiquitinating enzyme 43) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43)

Gene: UBP43, USP43
Organism: Homo sapiens
Interactions: 58
UniProt ID: Q70EL4

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination
GO:0019785 - ISG15-specific peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317190

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

17

High-throughput

0.691

High

729987

1433B
14-3-3 protein beta/alpha

5

20

Small-scale

0.654

High

1049470

1433F
14-3-3 protein eta

4

20

High-throughput

0.636

High

971690

1433E
14-3-3 protein epsilon

3

3

Small-scale

0.621

High

1066361

RBBP4
Histone-binding protein RBBP4

1

17

Small-scale

0.618

High

1158892

RBBP7
Histone-binding protein RBBP7

1

19

Small-scale

0.618

High

966517

1433G
14-3-3 protein gamma

3

20

High-throughput

0.604

High

1109839

HDAC1
Histone deacetylase 1

1

15

Small-scale

0.561

High

1258266

MTA3
Metastasis-associated protein MTA3

1

4

Small-scale

0.561

High

681188

PSA2
Proteasome subunit alpha type-2

1

5

High-throughput

0.536

High

702988

DPOD1
DNA polymerase delta catalytic subunit

1

2

High-throughput

0.536

High

960464

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

990395

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

995104

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.536

High

1258258

ATG4A
Cysteine protease ATG4A

1

1

High-throughput

0.536

High

1258261

DDX11
ATP-dependent DNA helicase DDX11

1

1

High-throughput

0.536

High

1258262

LCOR
Ligand-dependent corepressor

1

1

High-throughput

0.536

High

1258265

TRI56
E3 ubiquitin-protein ligase TRIM56

1

20

High-throughput

0.536

High

1258274

WDR3
WD repeat-containing protein 3

1

14

High-throughput

0.536

High

1013952

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.513

High

1117240

NCOA4
Nuclear receptor coactivator 4

1

0

High-throughput

0.513

High

1258272

TRM6
tRNA

1

0

High-throughput

0.513

High

754886

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.501

High

183669

RT12
Small ribosomal subunit protein uS12m

1

1

High-throughput

0.489

High

529995

TAU
Microtubule-associated protein tau

1

13

High-throughput

0.489

High

691163

1433T
14-3-3 protein theta

1

20

High-throughput

0.489

High

1215969

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

3

High-throughput

0.489

High

1247743

NHS
Actin remodeling regulator NHS

1

14

High-throughput

0.489

High

1258263

VPS35
Vacuolar protein sorting-associated protein 35

1

2

High-throughput

0.489

High

1258264

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.489

High

1258270

TRM7
tRNA

1

2

High-throughput

0.489

High

350052

SNAI1
Zinc finger protein SNAI1

1

12

Small-scale

0.479

High

352171

MBD3
Methyl-CpG-binding domain protein 3

1

2

Small-scale

0.479

High

374705

RASH
GTPase HRas

1

15

High-throughput

0.479

High

537389

HSP7C
Heat shock cognate 71 kDa protein

1

8

Small-scale

0.479

High

764854

CTNB1
Catenin beta-1

1

17

Small-scale

0.479

High

790064

ZEB1
Zinc finger E-box-binding homeobox 1

1

8

Small-scale

0.479

High

1045433

TF65
Transcription factor p65

1

10

High-throughput

0.479

High

1132774

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

8

Small-scale

0.479

High

1258257

INT1
Integrator complex subunit 1

1

1

High-throughput

0.479

High

1258259

RFFL
E3 ubiquitin-protein ligase rififylin

1

16

Small-scale

0.479

High

1258260

HDAC2
Histone deacetylase 2

1

15

Small-scale

0.479

High

1258255

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

7

High-throughput

0.445

High

249868

STX10
Syntaxin-10

1

3

High-throughput

0.437

High

556172

CADH1
Cadherin-1

1

3

High-throughput

0.437

High

730710

1433S
14-3-3 protein sigma

1

20

High-throughput

0.437

High

1258256

CEP57
Centrosomal protein of 57 kDa

1

1

High-throughput

0.437

High

1258269

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

Small-scale

0.437

High

1258271

XPO7
Exportin-7

1

10

High-throughput

0.437

High

1258273

SSRG
Translocon-associated protein subunit gamma

1

1

High-throughput

0.437

High

62234

A4D212
DKFZP586J0619 protein

1

1

High-throughput

0.407

High

91620

C9JA28
Translocon-associated protein subunit gamma

1

1

High-throughput

0.407

High

104029

F5GYW0
Centrosomal protein of 57 kDa

1

1

High-throughput

0.407

High

1217086

Q5U8S2
Syntaxin 10

1

2

High-throughput

0.407

High

322415

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

1157147

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.279

Low

1258267

KT3K
Ketosamine-3-kinase

1

0

High-throughput

0.279

Low

1258268

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025