Protein: TM165
Putative divalent cation/proton antiporter TMEM165 (Transmembrane protein 165) (Transmembrane protein PT27) (Transmembrane protein TPARL)

Gene: TM165, TMEM165
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q9HC07

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0005384 - manganese ion transmembrane transporter activity
GO:0005765 - lysosomal membrane
GO:0005794 - Golgi apparatus
GO:0006487 - protein N-linked glycosylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1114348

CUL3
Cullin-3

2

0

High-throughput

0.585

High

1395669

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.536

High

355378

B3GT4
Beta-1,3-galactosyltransferase 4

1

0

High-throughput

0.513

High

564393

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

905684

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1097895

STX5
Syntaxin-5

1

0

High-throughput

0.513

High

1218863

GP107
Protein GPR107

1

0

High-throughput

0.513

High

1350075

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1436685

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.513

High

1279551

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.489

High

1387070

COQ8B
Atypical kinase COQ8B, mitochondrial

1

1

High-throughput

0.489

High

1402674

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.489

High

374206

RASN
GTPase NRas

1

3

High-throughput

0.479

High

374943

RASH
GTPase HRas

1

2

High-throughput

0.479

High

375970

RASK
GTPase KRas

1

3

High-throughput

0.479

High

1367323

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1438523

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.479

High

133801

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.458

High

139995

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.458

High

218802

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

580701

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

693096

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

901053

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.458

High

956499

RAB2A
Ras-related protein Rab-2A

1

0

High-throughput

0.458

High

1178389

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1312606

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1383248

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1438519

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1438520

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1438525

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1415968

IFT27
Intraflagellar transport protein 27 homolog

1

1

High-throughput

0.445

High

404435

GCR
Glucocorticoid receptor

1

1

High-throughput

0.437

High

1356234

RN139
E3 ubiquitin-protein ligase RNF139

1

2

High-throughput

0.437

High

1432928

UN45A
Protein unc-45 homolog A

1

0

High-throughput

0.426

High

1049006

REL
Proto-oncogene c-Rel

1

0

High-throughput

0.282

High

1438517

AHSP
Alpha-hemoglobin-stabilizing protein

1

0

High-throughput

0.282

High

155358

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

0

High-throughput

0.279

Low

166048

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

182781

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

443527

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.279

Low

845139

EAA3
Excitatory amino acid transporter 3

1

0

High-throughput

0.279

Low

1104499

ILK
Scaffold protein ILK

1

0

High-throughput

0.279

Low

1161223

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.279

Low

1235335

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.279

Low

1258268

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

0

High-throughput

0.279

Low

1293911

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

0

High-throughput

0.279

Low

1431903

S38A1
Sodium-coupled neutral amino acid symporter 1

1

0

High-throughput

0.279

Low

1434642

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

1438515

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.279

Low

1438518

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.279

Low

1438522

GPTC8
G patch domain-containing protein 8

1

0

High-throughput

0.279

Low

1438524

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.279

Low

1286913

TM11B
Transmembrane protease serine 11B

1

0

High-throughput

0.269

Low

1438521

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.251

Low

122649

UBXN8
UBX domain-containing protein 8

1

0

High-throughput

0.249

Low

174616

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.249

Low

294353

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

414657

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

560104

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.249

Low

589742

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

643080

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

766869

PHB1
Prohibitin 1

1

0

High-throughput

0.249

Low

769228

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

831459

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

879485

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

883332

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.249

Low

1005115

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1012101

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.249

Low

1162563

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low

1163903

DUS7
Dual specificity protein phosphatase 7

1

0

High-throughput

0.249

Low

1203089

TM41B
Transmembrane protein 41B

1

0

High-throughput

0.249

Low

1218358

OTUD1
OTU domain-containing protein 1

1

0

Small-scale

0.249

Low

1221026

FBW10
F-box/WD repeat-containing protein 10

1

0

High-throughput

0.249

Low

1229692

VIR
Protein virilizer homolog

1

0

High-throughput

0.249

Low

1249227

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1252978

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1255616

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1276815

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1322997

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1326348

NIN
Ninein

1

0

High-throughput

0.249

Low

1327209

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1334944

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1429350

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1429939

BRD8
Bromodomain-containing protein 8

1

0

High-throughput

0.249

Low

1433939

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1435312

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.249

Low

1437872

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.249

Low

1438350

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.249

Low

1438516

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

217333

PROM1
Prominin-1

1

0

Small-scale

0.238

Low

1130

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

256159

S19A2
Thiamine transporter 1

1

0

High-throughput

0.232

Low

303287

S22A5
Organic cation/carnitine transporter 2

1

0

High-throughput

0.232

Low

993444

ACTH
Actin, gamma-enteric smooth muscle

1

0

High-throughput

0.232

Low

1219348

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

High-throughput

0.232

Low

1236326

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1381730

FAKD4
FAST kinase domain-containing protein 4

1

0

High-throughput

0.232

Low

1411645

ADPGK
ADP-dependent glucokinase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025