Protein: ORAI1
Calcium release-activated calcium channel protein 1 (Protein orai-1) (Transmembrane protein 142A)

Gene: ORAI1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q96D31

Gene Ontology (top 5):
GO:0002115 - store-operated calcium entry
GO:0002250 - adaptive immune response
GO:0005262 - calcium channel activity
GO:0005516 - calmodulin binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1386999

ORAI1
Calcium release-activated calcium channel protein 1

5

2

Small-scale

0.914

High

1387003

ORAI3
Protein orai-3

2

2

Small-scale

0.768

High

1111654

STIM1
Stromal interaction molecule 1

10

6

Small-scale

0.755

High

851081

LPAR6
Lysophosphatidic acid receptor 6

3

1

High-throughput

0.667

High

1351517

HAVR2
Hepatitis A virus cellular receptor 2

1

0

High-throughput

0.656

High

1387004

EFC4B
EF-hand calcium-binding domain-containing protein 4B

1

2

Small-scale

0.569

High

1108493

TRPC3
Short transient receptor potential channel 3

1

3

Small-scale

0.561

High

396680

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1047239

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

1291756

S22AG
Solute carrier family 22 member 16

1

1

High-throughput

0.536

High

1387006

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.536

High

1387014

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

1

High-throughput

0.536

High

63006

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

249505

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.513

High

854567

S15A1
Solute carrier family 15 member 1

1

0

High-throughput

0.513

High

867661

GPR12
G-protein coupled receptor 12

1

0

High-throughput

0.513

High

868006

GLR
Glucagon receptor

1

0

High-throughput

0.513

High

956973

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

1219320

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

High-throughput

0.513

High

1228841

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.513

High

1324750

S35F6
Solute carrier family 35 member F6

1

0

High-throughput

0.513

High

1356593

CHPT1
Cholinephosphotransferase 1

1

0

High-throughput

0.513

High

1386764

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.513

High

1387009

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.513

High

274404

AT2C2
Calcium-transporting ATPase type 2C member 2

1

0

Small-scale

0.512

High

1387015

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

1

1

High-throughput

0.489

High

878236

TRPC1
Short transient receptor potential channel 1

1

3

Small-scale

0.479

High

1277548

UBE3B
Ubiquitin-protein ligase E3B

1

1

High-throughput

0.470

High

1387001

TSN18
Tetraspanin-18

1

0

Small-scale

0.458

High

1387005

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1387013

UBQL1
Ubiquilin-1

1

0

Small-scale

0.458

High

1214896

WLS
Protein wntless homolog

1

0

Small-scale

0.438

High

1236265

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1387012

LAT2
Large neutral amino acids transporter small subunit 2

1

0

High-throughput

0.426

High

1386313

FAF2
FAS-associated factor 2

2

0

High-throughput

0.318

High

942508

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

0

High-throughput

0.279

Low

996801

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.279

Low

1108663

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.279

Low

1251303

HACD2
Very-long-chain

1

0

High-throughput

0.279

Low

1361076

CBPA5
Carboxypeptidase A5

1

0

High-throughput

0.279

Low

1383773

TTC28
Tetratricopeptide repeat protein 28

1

0

High-throughput

0.279

Low

1387002

CP2S1
Cytochrome P450 2S1

1

0

High-throughput

0.279

Low

1387007

SHRPN
Sharpin

1

0

High-throughput

0.279

Low

1387008

5NT3A
Cytosolic 5'-nucleotidase 3A

1

0

High-throughput

0.279

Low

1387011

INT7
Integrator complex subunit 7

1

0

High-throughput

0.279

Low

294150

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1330652

EFHB
EF-hand domain-containing family member B

1

0

Small-scale

0.249

Low

1387000

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

Small-scale

0.249

Low

1387010

BPIA1
BPI fold-containing family A member 1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025