Protein: PLSL
Plastin-2 (L-plastin) (LC64P) (Lymphocyte cytosolic protein 1) (LCP-1)

Gene: PLSL, LCP1
Organism: Homo sapiens
Interactions: 99
UniProt ID: P13796

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0001891 - phagocytic cup
GO:0002102 - podosome
GO:0002286 - T cell activation involved in immune response
GO:0003779 - actin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

568114

PLST
Plastin-3

6

15

High-throughput

0.940

High

568147

PLSI
Plastin-1

3

15

High-throughput

0.861

High

388979

FINC
Fibronectin

1

20

High-throughput

0.691

High

568132

PRKX
cAMP-dependent protein kinase catalytic subunit PRKX

1

3

High-throughput

0.691

High

568146

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

6

High-throughput

0.691

High

568174

RNF41
E3 ubiquitin-protein ligase NRDP1

3

12

High-throughput

0.662

High

568143

CENPE
Centromere-associated protein E

3

1

High-throughput

0.640

High

463892

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

15

High-throughput

0.618

High

568113

PLSL
Plastin-2

1

14

High-throughput

0.618

High

568122

GRAN
Grancalcin

1

5

Small-scale

0.618

High

568134

ACTB
Actin, cytoplasmic 1

1

20

High-throughput

0.618

High

568136

ACTG
Actin, cytoplasmic 2

1

20

High-throughput

0.618

High

568137

ACTC
Actin, alpha cardiac muscle 1

1

20

High-throughput

0.618

High

568193

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

1

High-throughput

0.618

High

568149

GLYR1
Cytokine-like nuclear factor N-PAC

2

3

High-throughput

0.611

High

568188

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

568116

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.586

High

568125

MYH11
Myosin-11

1

15

High-throughput

0.575

High

568141

TAGL
Transgelin

1

13

High-throughput

0.575

High

563103

CFTR
Cystic fibrosis transmembrane conductance regulator

2

9

High-throughput

0.571

High

568151

A16L1
Autophagy-related protein 16-1

2

10

High-throughput

0.571

High

210697

KLK10
Kallikrein-10

1

5

High-throughput

0.536

High

568117

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

568123

CCR1
C-C chemokine receptor type 1

1

6

High-throughput

0.536

High

568133

STX17
Syntaxin-17

1

1

High-throughput

0.536

High

568138

SSBP2
Single-stranded DNA-binding protein 2

1

4

High-throughput

0.536

High

568139

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.536

High

568142

GCYA1
Guanylate cyclase soluble subunit alpha-1

1

1

High-throughput

0.536

High

568172

EGFL8
Epidermal growth factor-like protein 8

1

7

High-throughput

0.536

High

568179

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

568186

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

1

High-throughput

0.536

High

568189

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.536

High

391554

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

568154

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.513

High

568183

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.513

High

325271

OR2A4
Olfactory receptor 2A4

1

2

High-throughput

0.489

High

568128

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

568148

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

568155

ELOA2
Elongin-A2

1

4

High-throughput

0.489

High

568157

FRMD1
FERM domain-containing protein 1

1

19

High-throughput

0.489

High

568161

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

568165

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

11

High-throughput

0.489

High

240630

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

324484

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

342732

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

373751

RASN
GTPase NRas

1

17

High-throughput

0.479

High

374374

RASH
GTPase HRas

1

12

High-throughput

0.479

High

375138

RASK
GTPase KRas

1

17

High-throughput

0.479

High

424054

ITB2
Integrin beta-2

1

16

High-throughput

0.479

High

568118

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

568126

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

Small-scale

0.479

High

568127

SOX2
Transcription factor SOX-2

1

10

High-throughput

0.479

High

568131

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.479

High

568135

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

9

High-throughput

0.479

High

568144

CUL4A
Cullin-4A

1

10

High-throughput

0.479

High

568153

HDGR2
Hepatoma-derived growth factor-related protein 2

1

4

High-throughput

0.479

High

568158

FBX22
F-box only protein 22

1

2

High-throughput

0.479

High

568160

BICD2
Protein bicaudal D homolog 2

1

20

High-throughput

0.479

High

568162

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

568163

REQU
Zinc finger protein ubi-d4

1

7

High-throughput

0.479

High

568166

BICD1
Protein bicaudal D homolog 1

1

20

High-throughput

0.479

High

568168

EYA1
Protein phosphatase EYA1

1

2

High-throughput

0.479

High

568169

ATX2
Ataxin-2

1

12

Small-scale

0.479

High

568170

H2B1M
Histone H2B type 1-M

1

8

High-throughput

0.479

High

568173

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

568178

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

7

High-throughput

0.479

High

568180

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

8

High-throughput

0.479

High

568182

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

5

High-throughput

0.479

High

568191

LOXL2
Lysyl oxidase homolog 2

1

5

High-throughput

0.479

High

542740

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

568140

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

261070

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.445

High

568119

CXCR2
C-X-C chemokine receptor type 2

1

6

Small-scale

0.445

High

568145

DAG1
Dystroglycan 1

1

5

Small-scale

0.445

High

568184

SPB13
Serpin B13

1

4

High-throughput

0.445

High

568185

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

3

High-throughput

0.445

High

105239

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

568115

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.437

High

568120

U2AF2
Splicing factor U2AF 65 kDa subunit

1

4

High-throughput

0.437

High

568121

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.437

High

568124

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

568129

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.437

High

568150

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

568181

ABCF3
ATP-binding cassette sub-family F member 3

1

1

High-throughput

0.437

High

568130

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.408

High

429220

JUN
Transcription factor Jun

1

8

High-throughput

0.407

High

568152

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

2

High-throughput

0.407

High

568190

AP3M1
AP-3 complex subunit mu-1

1

1

High-throughput

0.407

High

568159

TTL
Tubulin--tyrosine ligase

2

0

High-throughput

0.328

High

568156

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

568164

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

568167

SMIM8
Small integral membrane protein 8

1

0

High-throughput

0.279

Low

568171

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

568175

COE2
Transcription factor COE2

1

0

High-throughput

0.279

Low

568176

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.279

Low

568187

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

568192

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

568177

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025