Protein: CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1 (Voltage-gated calcium channel subunit alpha-2/delta-1) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1]

Gene: CA2D1, CACNA2D1
Organism: Homo sapiens
Interactions: 101
UniProt ID: P54289

Gene Ontology (top 5):
GO:0005245 - voltage-gated calcium channel activity
GO:0005886 - plasma membrane
GO:0005891 - voltage-gated calcium channel complex
GO:0006816 - calcium ion transport
GO:0016529 - sarcoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

154808

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

2

High-throughput

0.839

High

928784

BTNL8
Butyrophilin-like protein 8

2

2

High-throughput

0.789

High

928795

PRS33
Serine protease 33

2

1

High-throughput

0.726

High

731831

CEAM8
Cell adhesion molecule CEACAM8

1

3

High-throughput

0.691

High

928774

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

3

1

High-throughput

0.667

High

928781

SUSD4
Sushi domain-containing protein 4

2

0

High-throughput

0.660

High

928760

DEF1
Neutrophil defensin 1

2

2

High-throughput

0.628

High

928813

LMA2L
VIP36-like protein

2

1

High-throughput

0.628

High

321211

ERLN2
Erlin-2

2

1

High-throughput

0.611

High

928769

PTC1
Protein patched homolog 1

2

1

High-throughput

0.611

High

928775

TAZ
Tafazzin

3

1

High-throughput

0.609

High

337078

NPT2B
Sodium-dependent phosphate transport protein 2B

2

0

High-throughput

0.576

High

928770

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

2

High-throughput

0.575

High

928787

SG1D4
Secretoglobin family 1D member 4

2

5

High-throughput

0.574

High

928816

CG069
Putative uncharacterized protein PKD1L1-AS1

2

1

High-throughput

0.574

High

170716

CLGN
Calmegin

2

4

High-throughput

0.549

High

928780

DIK1A
Divergent protein kinase domain 1A

2

1

High-throughput

0.549

High

928801

PATE1
Prostate and testis expressed protein 1

2

1

High-throughput

0.549

High

928822

FBX2
F-box only protein 2

2

3

High-throughput

0.549

High

254903

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.546

High

351819

BY55
CD160 antigen

1

1

High-throughput

0.536

High

698519

CALX
Calnexin

1

4

High-throughput

0.536

High

814751

PA2G5
Phospholipase A2 group V

1

1

High-throughput

0.536

High

928757

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

928785

ALKL2
ALK and LTK ligand 2

1

1

High-throughput

0.536

High

928826

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.536

High

64943

ARRD5
Arrestin domain-containing protein 5

1

0

High-throughput

0.513

High

387647

APOC3
Apolipoprotein C-III

1

0

High-throughput

0.513

High

636487

FUT3
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3

1

0

High-throughput

0.513

High

906856

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

928765

ANK2
Ankyrin-2

1

0

High-throughput

0.513

High

928771

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

928805

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

928820

CNOT2
CCR4-NOT transcription complex subunit 2

1

0

High-throughput

0.513

High

67543

MYH7B
Myosin-7B

1

1

High-throughput

0.489

High

351674

SG1D1
Secretoglobin family 1D member 1

1

5

High-throughput

0.489

High

416603

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

2

High-throughput

0.489

High

928758

EP3B
Epididymal secretory protein E3-beta

1

3

High-throughput

0.489

High

928763

NDP
Norrin

1

1

High-throughput

0.489

High

928764

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.489

High

928772

EP3A
Epididymal secretory protein E3-alpha

1

3

High-throughput

0.489

High

928777

DB135
Beta-defensin 135

1

1

High-throughput

0.489

High

928779

NMS
Neuromedin-S

1

1

High-throughput

0.489

High

928782

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.489

High

928783

LYZL1
Lysozyme-like protein 1

1

2

High-throughput

0.489

High

928793

DB123
Beta-defensin 123

1

1

High-throughput

0.489

High

928806

LCFC1
Sperm-egg fusion protein LLCFC1

1

1

High-throughput

0.489

High

928808

CCL19
C-C motif chemokine 19

1

1

High-throughput

0.489

High

218000

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

928762

H33
Histone H3.3

1

1

High-throughput

0.479

High

928766

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

1

Small-scale

0.479

High

928767

LMAN2
Vesicular integral-membrane protein VIP36

1

1

High-throughput

0.479

High

928773

PON2
Serum paraoxonase/arylesterase 2

1

2

High-throughput

0.479

High

928803

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.479

High

928818

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

928825

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.479

High

928812

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

928814

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

211123

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.445

High

222259

PSCA
Prostate stem cell antigen

1

2

High-throughput

0.445

High

529412

TAU
Microtubule-associated protein tau

1

4

High-throughput

0.445

High

689985

CNTFR
Ciliary neurotrophic factor receptor subunit alpha

1

1

High-throughput

0.445

High

912646

CTR2
Cationic amino acid transporter 2

1

1

High-throughput

0.445

High

928788

ZNT10
Calcium/manganese antiporter SLC30A10

1

1

High-throughput

0.445

High

928798

MOT10
Monocarboxylate transporter 10

1

2

High-throughput

0.445

High

928800

CTL1
Choline transporter-like protein 1

1

1

High-throughput

0.445

High

928807

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

1

High-throughput

0.445

High

928809

S46A2
Solute carrier family 46 member 2

1

1

High-throughput

0.445

High

928821

RHCG
Ammonium transporter Rh type C

1

1

High-throughput

0.445

High

928823

S6A14
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)

1

1

High-throughput

0.445

High

928824

FLVC2
Choline/ethanolamine transporter FLVCR2

1

1

High-throughput

0.445

High

316794

MTA2
Metastasis-associated protein MTA2

1

1

High-throughput

0.437

High

617088

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

1

High-throughput

0.437

High

928768

MTA1
Metastasis-associated protein MTA1

1

1

High-throughput

0.437

High

928789

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

928802

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.437

High

538555

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.426

High

828572

S26A3
Chloride anion exchanger

1

0

High-throughput

0.426

High

880822

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

928776

SC5AC
Sodium-coupled monocarboxylate transporter 2

1

0

High-throughput

0.426

High

928790

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

928791

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.426

High

928810

S19A3
Thiamine transporter 2

1

0

High-throughput

0.426

High

928811

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

928817

SO1B3
Solute carrier organic anion transporter family member 1B3

1

0

High-throughput

0.426

High

928778

DB109
Beta-defensin 109B

1

1

High-throughput

0.407

High

928796

T185A
Transmembrane protein 185A

2

0

High-throughput

0.318

High

547316

CP19A
Aromatase

1

0

High-throughput

0.279

Low

928786

IGFL3
Insulin growth factor-like family member 3

1

0

High-throughput

0.279

Low

928799

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.279

Low

928804

CERS2
Ceramide synthase 2

1

0

High-throughput

0.279

Low

105633

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

371560

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

928761

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.249

Low

928797

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

928815

GL8D2
Glycosyltransferase 8 domain-containing protein 2

1

0

High-throughput

0.249

Low

928819

KTU
Protein kintoun

1

0

High-throughput

0.249

Low

73788

C1T9B
Complement C1q and tumor necrosis factor-related protein 9B

1

0

High-throughput

0.232

Low

928759

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.232

Low

928792

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low

928794

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025