Protein: UBP25
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)

Gene: UBP25, USP25
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q9UHP3

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476529

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

12

20

Small-scale

0.981

High

1355520

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

6

16

Small-scale

0.952

High

872318

RD23B
UV excision repair protein RAD23 homolog B

6

20

Small-scale

0.951

High

872227

RD23A
UV excision repair protein RAD23 homolog A

6

20

Small-scale

0.948

High

1301528

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

16

High-throughput

0.867

High

475225

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

High-throughput

0.811

High

1079625

NEDD8
NEDD8

2

17

Small-scale

0.776

High

796671

KSYK
Tyrosine-protein kinase SYK

6

16

Small-scale

0.741

High

902795

SUMO2
Small ubiquitin-related modifier 2

5

8

Small-scale

0.721

High

1330037

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

4

2

Small-scale

0.697

High

1329538

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

4

5

Small-scale

0.688

High

310103

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

5

Small-scale

0.684

High

678406

GDIA
Rab GDP dissociation inhibitor alpha

3

2

High-throughput

0.678

High

1264765

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

3

2

High-throughput

0.671

High

1300063

BTBD9
BTB/POZ domain-containing protein 9

3

10

High-throughput

0.671

High

1350370

KLHL9
Kelch-like protein 9

3

8

Small-scale

0.662

High

1042777

CUL3
Cullin-3

3

13

Small-scale

0.656

High

1355523

OCTC
Peroxisomal carnitine O-octanoyltransferase

3

0

High-throughput

0.638

High

1045949

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

2

2

High-throughput

0.628

High

879163

SUMO3
Small ubiquitin-related modifier 3

2

8

Small-scale

0.619

High

1041490

CUL2
Cullin-2

2

13

Small-scale

0.611

High

1355521

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

20

High-throughput

0.606

High

928224

SUMO1
Small ubiquitin-related modifier 1

2

8

Small-scale

0.602

High

1355524

MYO6
Unconventional myosin-VI

2

16

Small-scale

0.601

High

1350482

KLH13
Kelch-like protein 13

2

8

Small-scale

0.584

High

1109782

PUS10
tRNA pseudouridine synthase Pus10

2

0

High-throughput

0.580

High

1162249

LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

2

3

High-throughput

0.574

High

180580

MAGB4
Melanoma-associated antigen B4

1

10

High-throughput

0.573

High

1313345

ZN426
Zinc finger protein 426

1

3

High-throughput

0.573

High

962517

MYPC1
Myosin-binding protein C, slow-type

1

4

Small-scale

0.552

High

428485

TBB5
Tubulin beta chain

1

12

High-throughput

0.541

High

442573

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

10

High-throughput

0.541

High

757789

IF4A3
Eukaryotic initiation factor 4A-III

1

10

High-throughput

0.541

High

870702

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.541

High

1169003

ZN841
Zinc finger protein 841

1

1

High-throughput

0.541

High

1216854

ARMC8
Armadillo repeat-containing protein 8

1

6

High-throughput

0.541

High

1303678

NP1L3
Nucleosome assembly protein 1-like 3

1

9

High-throughput

0.541

High

930440

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.536

High

846538

BLK
Tyrosine-protein kinase Blk

1

8

High-throughput

0.536

High

1020973

TRAF2
TNF receptor-associated factor 2

1

20

High-throughput

0.536

High

1201371

IGFN1
Immunoglobulin-like and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.536

High

1268466

APBP2
Amyloid protein-binding protein 2

1

3

High-throughput

0.536

High

1291322

DYL2
Dynein light chain 2, cytoplasmic

1

2

High-throughput

0.536

High

1327498

BTBD1
BTB/POZ domain-containing protein 1

1

10

High-throughput

0.536

High

1331812

RNF41
E3 ubiquitin-protein ligase NRDP1

1

20

High-throughput

0.536

High

933071

ACTS
Actin, alpha skeletal muscle

1

5

Small-scale

0.527

High

1158341

CDC73
Parafibromin

1

2

Small-scale

0.527

High

641592

PAX6
Paired box protein Pax-6

1

0

High-throughput

0.518

High

376330

ANXA1
Annexin A1

1

4

High-throughput

0.515

High

519104

PIP
Prolactin-inducible protein

1

1

High-throughput

0.515

High

1301754

WRIP1
ATPase WRNIP1

1

3

High-throughput

0.515

High

568820

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

High-throughput

0.515

High

740082

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

847953

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.513

High

1161500

DCNL2
DCN1-like protein 2

1

0

High-throughput

0.513

High

1018313

CNTN1
Contactin-1

1

1

Small-scale

0.512

High

1190123

MAVS
Mitochondrial antiviral-signaling protein

1

14

Small-scale

0.512

High

1349829

SENP1
Sentrin-specific protease 1

1

5

Small-scale

0.501

High

281459

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.494

High

1345173

VPS45
Vacuolar protein sorting-associated protein 45

1

3

High-throughput

0.494

High

1287940

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.493

High

521401

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

365293

MT2
Metallothionein-2

1

1

Small-scale

0.481

High

382175

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

Small-scale

0.481

High

1052958

FLNC
Filamin-C

1

8

Small-scale

0.481

High

129604

TRAF5
TNF receptor-associated factor 5

1

20

Small-scale

0.479

High

396001

A4
Amyloid-beta precursor protein

1

7

Small-scale

0.479

High

561707

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

6

Small-scale

0.479

High

580157

K2C4
Keratin, type II cytoskeletal 4

1

4

High-throughput

0.479

High

872588

EPHB4
Ephrin type-B receptor 4

1

5

High-throughput

0.479

High

890879

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

11

Small-scale

0.479

High

1024782

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

1043635

CUL4B
Cullin-4B

1

13

High-throughput

0.479

High

1085708

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

Small-scale

0.479

High

1161754

KLD10
Kelch domain-containing protein 10

1

10

Small-scale

0.479

High

1172156

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1206206

HORN
Hornerin

1

7

Small-scale

0.479

High

1237511

CGAS
Cyclic GMP-AMP synthase

1

2

Small-scale

0.479

High

1268029

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

1288049

HDA11
Histone deacetylase 11

1

11

Small-scale

0.479

High

1296948

SNX27
Sorting nexin-27

1

7

High-throughput

0.479

High

1305973

BARD1
BRCA1-associated RING domain protein 1

1

7

Small-scale

0.479

High

1317960

ASPC1
Tether containing UBX domain for GLUT4

1

2

Small-scale

0.479

High

1335824

SENP2
Sentrin-specific protease 2

1

5

Small-scale

0.479

High

1355522

FEM1B
Protein fem-1 homolog B

1

5

Small-scale

0.479

High

1355525

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

901627

LYSC
Lysozyme C

1

1

High-throughput

0.470

High

1354638

FXL17
F-box/LRR-repeat protein 17

1

0

Small-scale

0.460

High

1348685

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

Small-scale

0.458

High

1355527

S4R435
Small ribosomal subunit protein eS10

1

2

High-throughput

0.457

High

1312367

TMM43
Transmembrane protein 43

2

0

High-throughput

0.316

High

485880

PYY
Peptide YY

1

0

High-throughput

0.279

Low

1355526

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024