Protein: MRE11
Double-strand break repair protein MRE11 (EC 3.1.-.-) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)

Gene: MRE11
Organism: Homo sapiens
Interactions: 233
UniProt ID: P49959

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000019 - regulation of mitotic recombination
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000729 - DNA double-strand break processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

262041

NBN
Nibrin

43

2

Small-scale

0.994

High

892912

RAD50
DNA repair protein RAD50

39

6

Small-scale

0.993

High

892824

MRE11
Double-strand break repair protein MRE11

5

4

Small-scale

0.922

High

892868

MDC1
Mediator of DNA damage checkpoint protein 1

7

4

Small-scale

0.751

High

798851

BRCA1
Breast cancer type 1 susceptibility protein

10

2

Small-scale

0.750

High

892926

CTIP
DNA endonuclease RBBP8

10

0

Small-scale

0.722

High

892856

ATM
Serine-protein kinase ATM

5

6

Small-scale

0.708

High

694937

RFA1
Replication protein A 70 kDa DNA-binding subunit

5

1

Small-scale

0.702

High

853936

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.691

High

413422

P53
Cellular tumor antigen p53

4

1

Small-scale

0.680

High

591538

H2AX
Histone H2AX

5

0

Small-scale

0.673

High

892875

TERF2
Telomeric repeat-binding factor 2

4

0

Small-scale

0.651

High

892896

SLX4
Structure-specific endonuclease subunit SLX4

3

2

Small-scale

0.640

High

855409

ATRX
Transcriptional regulator ATRX

3

3

Small-scale

0.633

High

557953

XRCC6
X-ray repair cross-complementing protein 6

2

1

Small-scale

0.631

High

892828

BLM
RecQ-like DNA helicase BLM

3

3

Small-scale

0.624

High

892937

FACD2
Fanconi anemia group D2 protein

2

0

Small-scale

0.623

High

461278

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.618

High

892866

RAB32
Ras-related protein Rab-32

1

2

High-throughput

0.618

High

303121

RGS20
Regulator of G-protein signaling 20

2

1

High-throughput

0.611

High

892825

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

2

High-throughput

0.611

High

892834

H4
Histone H4

3

0

Small-scale

0.604

High

892832

SUMO2
Small ubiquitin-related modifier 2

2

2

High-throughput

0.602

High

892877

H31T
Histone H3.1t

2

1

Small-scale

0.601

High

892935

FANCJ
Fanconi anemia group J protein

2

0

Small-scale

0.598

High

159570

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.586

High

247261

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.586

High

411588

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.586

High

892835

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.586

High

892895

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.586

High

241100

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

259635

BRD4
Bromodomain-containing protein 4

2

3

High-throughput

0.584

High

302786

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

2

1

High-throughput

0.584

High

315291

RECQ4
ATP-dependent DNA helicase Q4

2

3

Small-scale

0.584

High

345531

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

588213

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

861926

YAP1
Transcriptional coactivator YAP1

2

2

Small-scale

0.584

High

892915

FBXW7
F-box/WD repeat-containing protein 7

2

1

Small-scale

0.584

High

892920

DCR1C
Protein artemis

2

1

Small-scale

0.584

High

892929

ANM1
Protein arginine N-methyltransferase 1

2

1

Small-scale

0.584

High

892950

UBQL4
Ubiquilin-4

2

1

Small-scale

0.584

High

892892

RAB43
Ras-related protein Rab-43

1

0

High-throughput

0.578

High

395709

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

316267

RECQ5
ATP-dependent DNA helicase Q5

1

3

Small-scale

0.561

High

767707

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

892827

PLK1
Serine/threonine-protein kinase PLK1

2

0

Small-scale

0.559

High

892954

NALP2
NACHT, LRR and PYD domains-containing protein 2

2

0

Small-scale

0.559

High

892956

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

2

0

Small-scale

0.559

High

667652

CDK2
Cyclin-dependent kinase 2

1

1

Small-scale

0.552

High

892857

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

2

0

High-throughput

0.551

High

289958

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

596000

H12
Histone H1.2

1

0

Small-scale

0.537

High

892836

GRB2
Growth factor receptor-bound protein 2

1

0

Small-scale

0.537

High

892838

DYL1
Dynein light chain 1, cytoplasmic

1

0

Small-scale

0.537

High

892939

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.537

High

166131

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

171681

GAK
Cyclin-G-associated kinase

1

1

High-throughput

0.536

High

342128

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.536

High

892833

ERR3
Estrogen-related receptor gamma

1

2

High-throughput

0.536

High

892878

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

892923

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

666963

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.515

High

892907

TOPB1
DNA topoisomerase 2-binding protein 1

1

3

High-throughput

0.515

High

74454

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

466641

GLI1
Zinc finger protein GLI1

1

0

High-throughput

0.513

High

481162

HMGB1
High mobility group protein B1

1

0

High-throughput

0.513

High

892841

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

892863

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

892871

NUMA1
Nuclear mitotic apparatus protein 1

1

0

High-throughput

0.513

High

892900

NECP1
Adaptin ear-binding coat-associated protein 1

1

0

High-throughput

0.513

High

892902

TDRD7
Tudor domain-containing protein 7

1

0

High-throughput

0.513

High

892940

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.513

High

892941

FOXP1
Forkhead box protein P1

1

0

High-throughput

0.513

High

892952

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

Small-scale

0.513

High

892837

SUMO1
Small ubiquitin-related modifier 1

1

2

High-throughput

0.501

High

298585

RAD17
Cell cycle checkpoint protein RAD17

1

1

Small-scale

0.500

High

892845

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.493

High

892919

NEK1
Serine/threonine-protein kinase Nek1

1

0

Small-scale

0.486

High

617434

DNLI1
DNA ligase 1

1

2

Small-scale

0.481

High

892925

CDX2
Homeobox protein CDX-2

1

0

Small-scale

0.480

High

892928

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.480

High

662543

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

0

High-throughput

0.479

High

892851

ILF2
Interleukin enhancer-binding factor 2

1

0

Small-scale

0.479

High

892888

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

Small-scale

0.479

High

174495

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.479

High

179690

MDM4
Protein Mdm4

1

2

Small-scale

0.479

High

285147

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

302433

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

Small-scale

0.479

High

365748

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.479

High

519850

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

567307

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

606436

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

667215

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

754766

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

789440

PPARG
Peroxisome proliferator-activated receptor gamma

1

3

Small-scale

0.479

High

830350

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

892831

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

1

High-throughput

0.479

High

892839

H31
Histone H3.1

1

1

High-throughput

0.479

High

892842

MDM2
E3 ubiquitin-protein ligase Mdm2

1

2

Small-scale

0.479

High

892846

ERCC6
DNA excision repair protein ERCC-6

1

2

Small-scale

0.479

High

892848

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

892849

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

892850

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

892852

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.479

High

892853

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

892854

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

892855

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

892859

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

892860

BIRC2
Baculoviral IAP repeat-containing protein 2

1

3

Small-scale

0.479

High

892864

CUL3
Cullin-3

1

1

High-throughput

0.479

High

892870

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

892880

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

892882

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

892883

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

892886

PAXI1
PAX-interacting protein 1

1

2

Small-scale

0.479

High

892909

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

892910

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

892911

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

892918

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

4

Small-scale

0.479

High

892931

TINF2
TERF1-interacting nuclear factor 2

1

1

High-throughput

0.479

High

892932

PCGF1
Polycomb group RING finger protein 1

1

1

High-throughput

0.479

High

892938

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

892944

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

892946

DCR1B
5' exonuclease Apollo

1

1

Small-scale

0.479

High

892949

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

892951

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

Small-scale

0.479

High

892957

HDAC6
Protein deacetylase HDAC6

1

1

Small-scale

0.479

High

892960

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

892962

FBW1B
F-box/WD repeat-containing protein 11

1

1

High-throughput

0.479

High

892963

BRPF3
Bromodomain and PHD finger-containing protein 3

1

3

High-throughput

0.479

High

892965

TRRAP
Transformation/transcription domain-associated protein

1

6

Small-scale

0.479

High

227432

SPOP
Speckle-type POZ protein

1

0

Small-scale

0.460

High

128864

MEN1
Menin

1

0

High-throughput

0.458

High

168211

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

Small-scale

0.458

High

171851

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

222834

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

271992

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

281148

DPOLQ
DNA polymerase theta

1

0

Small-scale

0.458

High

293382

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319530

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

341912

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

371485

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

385562

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

386448

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.458

High

400488

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

507687

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

536761

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

542391

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.458

High

555959

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

617666

XRCC1
DNA repair protein XRCC1

1

0

Small-scale

0.458

High

629083

CCNA2
Cyclin-A2

1

0

Small-scale

0.458

High

731088

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

878783

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

884292

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

892829

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

892830

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

892843

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

892844

SEMG2
Semenogelin-2

1

0

Small-scale

0.458

High

892847

RBBP4
Histone-binding protein RBBP4

1

0

Small-scale

0.458

High

892858

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

892861

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

892869

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

892872

CUL7
Cullin-7

1

0

High-throughput

0.458

High

892873

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

892874

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

892876

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

892879

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

892881

ODFP2
Outer dense fiber protein 2

1

0

High-throughput

0.458

High

892885

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

892887

ZN365
Protein ZNF365

1

0

Small-scale

0.458

High

892889

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

892890

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

892891

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

892894

SKA3
Spindle and kinetochore-associated protein 3

1

0

Small-scale

0.458

High

892897

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

892901

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.458

High

892904

ATRIP
ATR-interacting protein

1

0

Small-scale

0.458

High

892905

DDX1
ATP-dependent RNA helicase DDX1

1

0

Small-scale

0.458

High

892906

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

892908

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

892913

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

892914

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

892917

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

1

0

Small-scale

0.458

High

892924

NECD
Necdin

1

0

High-throughput

0.458

High

892927

BARD1
BRCA1-associated RING domain protein 1

1

0

Small-scale

0.458

High

892930

SOSB1
SOSS complex subunit B1

1

0

Small-scale

0.458

High

892933

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.458

High

892934

CYREN
Cell cycle regulator of non-homologous end joining

1

0

Small-scale

0.458

High

892936

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

892942

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

892943

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

892945

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

892947

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

892948

ANLN
Anillin

1

0

High-throughput

0.458

High

892955

MCM9
DNA helicase MCM9

1

0

Small-scale

0.458

High

892959

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

892964

POLH
DNA polymerase eta

1

0

Small-scale

0.458

High

892966

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.458

High

429534

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

487094

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.445

High

846566

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.445

High

892826

MSH6
DNA mismatch repair protein Msh6

1

2

Small-scale

0.445

High

892916

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

Small-scale

0.445

High

843386

HD
Huntingtin

1

0

High-throughput

0.438

High

892898

FBXL6
F-box/LRR-repeat protein 6

1

1

High-throughput

0.437

High

231552

PRKY
Putative serine/threonine-protein kinase PRKY

1

0

High-throughput

0.426

High

397916

ANGI
Angiogenin

1

0

High-throughput

0.426

High

697042

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.426

High

769950

RFC1
Replication factor C subunit 1

1

0

Small-scale

0.426

High

827348

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.426

High

892958

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.426

High

886639

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

892840

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.408

High

892862

ATR
Serine/threonine-protein kinase ATR

1

6

Small-scale

0.408

High

75559

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

892893

F219A
Protein FAM219A

4

0

High-throughput

0.360

High

467712

CEL2B
Chymotrypsin-like elastase family member 2B

3

0

High-throughput

0.347

High

562706

BMP1
Bone morphogenetic protein 1

2

0

High-throughput

0.328

High

892884

CF161
Cilia- and flagella-associated protein 161

2

0

High-throughput

0.318

High

892961

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

2

0

High-throughput

0.313

High

718377

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

892903

SCG3
Secretogranin-3

1

0

High-throughput

0.279

Low

892921

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

702176

LYOX
Protein-lysine 6-oxidase

1

0

Small-scale

0.261

Low

105582

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

642724

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

892865

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

892867

TRI29
Tripartite motif-containing protein 29

1

0

Small-scale

0.249

Low

892922

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

892953

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

62473

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

892899

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025