Protein: EPAS1
Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)

Gene: EPAS1
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q99814

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

772130

VHL
von Hippel-Lindau disease tumor suppressor

20

8

Small-scale

0.987

High

649150

ARNT
Aryl hydrocarbon receptor nuclear translocator

16

20

Small-scale

0.987

High

1306535

EGLN1
Egl nine homolog 1

7

14

Small-scale

0.959

High

999019

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.885

High

1306537

EGLN3
Prolyl hydroxylase EGLN3

3

14

Small-scale

0.844

High

126166

BMAL1
Basic helix-loop-helix ARNT-like protein 1

3

19

Small-scale

0.839

High

1264408

BMAL2
Basic helix-loop-helix ARNT-like protein 2

3

19

Small-scale

0.839

High

1306541

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

2

19

Small-scale

0.793

High

1296543

EGLN2
Prolyl hydroxylase EGLN2

2

14

Small-scale

0.785

High

1306527

EPAS1
Endothelial PAS domain-containing protein 1

2

19

Small-scale

0.768

High

1270775

CBP
CREB-binding protein

2

20

Small-scale

0.754

High

898184

MAX
Protein max

1

8

Small-scale

0.665

High

1306561

NEMO
NF-kappa-B essential modulator

2

16

Small-scale

0.651

High

252930

MITF
Microphthalmia-associated transcription factor

1

19

Small-scale

0.618

High

1079725

USF2
Upstream stimulatory factor 2

1

9

Small-scale

0.618

High

1085655

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.618

High

1306557

HIF3A
Hypoxia-inducible factor 3-alpha

1

19

Small-scale

0.618

High

1072435

ELOB
Elongin-B

2

2

Small-scale

0.611

High

1306555

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

11

High-throughput

0.606

High

432201

HS90A
Heat shock protein HSP 90-alpha

2

17

Small-scale

0.595

High

435165

SP1
Transcription factor Sp1

2

12

Small-scale

0.584

High

450932

F16P1
Fructose-1,6-bisphosphatase 1

1

1

Small-scale

0.578

High

370292

ESR1
Estrogen receptor

1

20

Small-scale

0.573

High

542426

PLAK
Junction plakoglobin

1

20

Small-scale

0.561

High

777070

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.561

High

1059825

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

Small-scale

0.561

High

1289409

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

8

Small-scale

0.561

High

1304918

NECD
Necdin

1

14

Small-scale

0.561

High

1301030

BBS4
Bardet-Biedl syndrome 4 protein

1

2

Small-scale

0.552

High

1306556

KLH20
Kelch-like protein 20

1

3

Small-scale

0.552

High

626238

APC
Adenomatous polyposis coli protein

1

10

High-throughput

0.541

High

987227

MEF2C
Myocyte-specific enhancer factor 2C

1

1

High-throughput

0.541

High

1306548

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.541

High

391865

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.536

High

396790

S10A8
Protein S100-A8

1

5

High-throughput

0.536

High

416500

S10A9
Protein S100-A9

1

5

High-throughput

0.536

High

625014

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.536

High

1041447

CUL2
Cullin-2

1

8

High-throughput

0.536

High

1072294

ELOC
Elongin-C

1

2

High-throughput

0.536

High

1306543

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

2

High-throughput

0.536

High

1306545

RNC
Ribonuclease 3

1

2

Small-scale

0.536

High

888429

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

1

Small-scale

0.529

High

181448

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.513

High

345131

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

583560

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.513

High

583779

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

738874

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.513

High

854353

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.513

High

913944

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.513

High

1306531

RBM4
RNA-binding protein 4

1

0

Small-scale

0.513

High

341459

FA12
Coagulation factor XII

1

3

Small-scale

0.512

High

950263

SMAD3
Mothers against decapentaplegic homolog 3

1

8

High-throughput

0.508

High

131501

IMA4
Importin subunit alpha-4

1

13

Small-scale

0.501

High

168664

IMA6
Importin subunit alpha-6

1

13

Small-scale

0.501

High

238729

IMA7
Importin subunit alpha-7

1

13

Small-scale

0.501

High

402393

JUN
Transcription factor Jun

1

12

High-throughput

0.501

High

794562

ETV4
ETS translocation variant 4

1

17

Small-scale

0.501

High

853691

IMA5
Importin subunit alpha-5

1

13

Small-scale

0.501

High

1014253

DBP
D site-binding protein

1

9

High-throughput

0.501

High

1060894

IMB1
Importin subunit beta-1

1

2

Small-scale

0.501

High

1082110

BATF
Basic leucine zipper transcriptional factor ATF-like

1

8

High-throughput

0.501

High

1231011

BATF2
Basic leucine zipper transcriptional factor ATF-like 2

1

2

High-throughput

0.501

High

1306544

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

9

High-throughput

0.501

High

237300

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

Small-scale

0.500

High

892883

IF4A1
Eukaryotic initiation factor 4A-I

1

1

Small-scale

0.500

High

1245476

OR6K3
Olfactory receptor 6K3

1

1

High-throughput

0.489

High

1244828

BBS1
Bardet-Biedl syndrome 1 protein

1

0

Small-scale

0.486

High

1306533

BBS2
Bardet-Biedl syndrome 2 protein

1

0

Small-scale

0.486

High

786632

STA5A
Signal transducer and activator of transcription 5A

1

6

High-throughput

0.481

High

967389

EWS
RNA-binding protein EWS

1

4

High-throughput

0.481

High

727184

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.480

High

869723

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.480

High

158533

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

7

Small-scale

0.479

High

507204

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

Small-scale

0.479

High

1251610

SMRC2
SWI/SNF complex subunit SMARCC2

1

15

Small-scale

0.479

High

163188

XPO1
Exportin-1

1

7

Small-scale

0.479

High

225413

MED14
Mediator of RNA polymerase II transcription subunit 14

1

14

Small-scale

0.479

High

232463

KDM1A
Lysine-specific histone demethylase 1A

1

6

Small-scale

0.479

High

243571

DNJA2
DnaJ homolog subfamily A member 2

1

11

Small-scale

0.479

High

278327

PIAS2
E3 SUMO-protein ligase PIAS2

1

5

Small-scale

0.479

High

305809

ELP1
Elongator complex protein 1

1

1

Small-scale

0.479

High

323991

BAG2
BAG family molecular chaperone regulator 2

1

5

Small-scale

0.479

High

403683

AP2A
Transcription factor AP-2-alpha

1

1

Small-scale

0.479

High

476267

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.479

High

486957

MYBB
Myb-related protein B

1

1

Small-scale

0.479

High

523966

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.479

High

525036

XRCC5
X-ray repair cross-complementing protein 5

1

5

Small-scale

0.479

High

538007

KPYM
Pyruvate kinase PKM

1

3

Small-scale

0.479

High

542070

ETS1
Protein C-ets-1

1

17

Small-scale

0.479

High

573058

PRS6A
26S proteasome regulatory subunit 6A

1

11

Small-scale

0.479

High

584271

ELK1
ETS domain-containing protein Elk-1

1

17

Small-scale

0.479

High

594617

PSB1
Proteasome subunit beta type-1

1

4

Small-scale

0.479

High

627343

MCM3
DNA replication licensing factor MCM3

1

6

Small-scale

0.479

High

709022

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

714381

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.479

High

717306

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

719086

PHB1
Prohibitin 1

1

1

Small-scale

0.479

High

789329

CNDD3
Condensin-2 complex subunit D3

1

1

Small-scale

0.479

High

846861

SMCA2
Probable global transcription activator SNF2L2

1

9

Small-scale

0.479

High

847066

SMCA4
Transcription activator BRG1

1

9

Small-scale

0.479

High

881827

SOX10
Transcription factor SOX-10

1

20

Small-scale

0.479

High

903008

DCAF7
DDB1- and CUL4-associated factor 7

1

5

Small-scale

0.479

High

928179

SUMO1
Small ubiquitin-related modifier 1

1

3

Small-scale

0.479

High

929632

RACK1
Small ribosomal subunit protein RACK1

1

11

Small-scale

0.479

High

944392

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

Small-scale

0.479

High

969941

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

992040

BAX
Apoptosis regulator BAX

1

5

Small-scale

0.479

High

1017220

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

1029790

TIF1B
Transcription intermediary factor 1-beta

1

12

Small-scale

0.479

High

1036844

SQSTM
Sequestosome-1

1

2

Small-scale

0.479

High

1038669

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.479

High

1076194

MED1
Mediator of RNA polymerase II transcription subunit 1

1

6

Small-scale

0.479

High

1121190

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

11

Small-scale

0.479

High

1151629

OTU7B
OTU domain-containing protein 7B

1

2

Small-scale

0.479

High

1198270

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

12

Small-scale

0.479

High

1244293

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

Small-scale

0.479

High

1244997

TET1
Methylcytosine dioxygenase TET1

1

1

Small-scale

0.479

High

1257024

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

9

Small-scale

0.479

High

1270407

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.479

High

1270680

REQU
Zinc finger protein ubi-d4

1

8

Small-scale

0.479

High

1272925

SMRC1
SWI/SNF complex subunit SMARCC1

1

17

Small-scale

0.479

High

1274337

MED12
Mediator of RNA polymerase II transcription subunit 12

1

19

Small-scale

0.479

High

1285256

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

1

3

Small-scale

0.479

High

1291840

MED8
Mediator of RNA polymerase II transcription subunit 8

1

1

Small-scale

0.479

High

1301086

MED15
Mediator of RNA polymerase II transcription subunit 15

1

16

Small-scale

0.479

High

1302433

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.479

High

1303911

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

4

Small-scale

0.479

High

1305229

PHB2
Prohibitin-2

1

1

Small-scale

0.479

High

1306532

SSBP3
Single-stranded DNA-binding protein 3

1

1

Small-scale

0.479

High

1306540

UBP29
Ubiquitin carboxyl-terminal hydrolase 29

1

11

Small-scale

0.479

High

1306549

MED11
Mediator of RNA polymerase II transcription subunit 11

1

1

Small-scale

0.479

High

1306551

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

Small-scale

0.479

High

1306553

CHIP
E3 ubiquitin-protein ligase CHIP

1

14

Small-scale

0.479

High

1306554

TRI33
E3 ubiquitin-protein ligase TRIM33

1

20

Small-scale

0.479

High

1306559

YTHD2
YTH domain-containing family protein 2

1

1

Small-scale

0.479

High

1306560

TF3C3
General transcription factor 3C polypeptide 3

1

3

Small-scale

0.479

High

61446

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

Small-scale

0.458

High

206642

MED7
Mediator of RNA polymerase II transcription subunit 7

1

0

Small-scale

0.458

High

265357

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

Small-scale

0.458

High

313460

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

Small-scale

0.458

High

418583

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

839079

EMD
Emerin

1

0

Small-scale

0.458

High

1074721

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

Small-scale

0.458

High

1158916

MED27
Mediator of RNA polymerase II transcription subunit 27

1

0

Small-scale

0.458

High

1174956

MED25
Mediator of RNA polymerase II transcription subunit 25

1

0

Small-scale

0.458

High

1260819

BCL7C
B-cell CLL/lymphoma 7 protein family member C

1

0

Small-scale

0.458

High

1306528

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

Small-scale

0.458

High

1306529

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

1306530

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1306534

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.458

High

1306536

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

Small-scale

0.458

High

1306538

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.458

High

1306539

CNO10
CCR4-NOT transcription complex subunit 10

1

0

Small-scale

0.458

High

1306542

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

Small-scale

0.458

High

1306546

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.458

High

1306547

MED29
Mediator of RNA polymerase II transcription subunit 29

1

0

Small-scale

0.458

High

1306550

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

Small-scale

0.458

High

1306552

AKP8L
A-kinase anchor protein 8-like

1

0

Small-scale

0.458

High

1306558

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.458

High

1301737

WRIP1
ATPase WRNIP1

1

5

Small-scale

0.437

High

428695

TRY1
Serine protease 1

1

0

High-throughput

0.279

Low

1068054

PDK1
[Pyruvate dehydrogenase

1

0

Small-scale

0.261

Low

489616

OSTP
Osteopontin

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024