Protein: POLK
DNA polymerase kappa (EC 2.7.7.7) (DINB protein) (DINP)

Gene: POLK
Organism: Homo sapiens
Interactions: 57
UniProt ID: Q9UBT6

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006260 - DNA replication

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458718

REV1
DNA repair protein REV1

6

14

Small-scale

0.948

High

551312

PCNA
Proliferating cell nuclear antigen

5

14

Small-scale

0.920

High

1328685

KCD17
BTB/POZ domain-containing protein KCTD17

4

2

High-throughput

0.630

High

1449240

RAD18
E3 ubiquitin-protein ligase RAD18

2

2

Small-scale

0.624

High

1438313

PARVG
Gamma-parvin

3

1

High-throughput

0.609

High

414770

P53
Cellular tumor antigen p53

2

3

High-throughput

0.584

High

1458719

XPO7
Exportin-7

2

1

Small-scale

0.584

High

297701

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

High-throughput

0.536

High

1055991

RAD51
DNA repair protein RAD51 homolog 1

1

1

High-throughput

0.536

High

1154301

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

2

High-throughput

0.536

High

1416138

RBM4
RNA-binding protein 4

1

2

High-throughput

0.536

High

1416936

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.536

High

1452136

KCTD5
BTB/POZ domain-containing protein KCTD5

1

2

High-throughput

0.536

High

535630

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.515

High

573711

ENPL
Endoplasmin

1

5

High-throughput

0.515

High

1162067

H31T
Histone H3.1t

1

4

High-throughput

0.515

High

335926

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

1

0

High-throughput

0.513

High

838256

STAT6
Signal transducer and activator of transcription 6

1

0

High-throughput

0.513

High

1127221

RBM39
RNA-binding protein 39

1

0

High-throughput

0.513

High

1134562

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

High-throughput

0.513

High

1219441

TUT7
Terminal uridylyltransferase 7

1

0

High-throughput

0.513

High

1248091

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.513

High

1286271

PCGF5
Polycomb group RING finger protein 5

1

0

High-throughput

0.513

High

1416243

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.513

High

1421337

BHE41
Class E basic helix-loop-helix protein 41

1

0

High-throughput

0.513

High

1439516

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

386324

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.493

High

1352242

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

High-throughput

0.493

High

1416101

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

Small-scale

0.481

High

1122961

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

0

Small-scale

0.480

High

617748

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.479

High

703079

DPOD1
DNA polymerase delta catalytic subunit

1

5

Small-scale

0.479

High

714487

PML
Protein PML

1

1

High-throughput

0.479

High

726809

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

1

High-throughput

0.479

High

755811

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.479

High

846690

MSH2
DNA mismatch repair protein Msh2

1

4

Small-scale

0.479

High

913420

MSH6
DNA mismatch repair protein Msh6

1

4

Small-scale

0.479

High

1017268

H33
Histone H3.3

1

4

High-throughput

0.479

High

1114544

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1128303

MCM6
DNA replication licensing factor MCM6

1

3

Small-scale

0.479

High

1145554

RBBP5
Retinoblastoma-binding protein 5

1

1

High-throughput

0.479

High

1314461

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

1458720

SYNP2
Synaptopodin-2

1

1

High-throughput

0.479

High

1130031

KCTD2
BTB/POZ domain-containing protein KCTD2

1

2

High-throughput

0.470

High

696760

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

Small-scale

0.458

High

1244841

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

107424

F8W8I6
Cytotoxic granule associated RNA binding protein TIA1

1

1

High-throughput

0.445

High

114479

H0Y9Y3
Synaptopodin 2

1

1

High-throughput

0.445

High

117249

K7EK07
Histone H3

1

4

High-throughput

0.445

High

1322320

SPART
Spartin

2

0

High-throughput

0.328

High

907947

PLXA3
Plexin-A3

1

0

High-throughput

0.279

Low

1248748

SBSN
Suprabasin

1

0

High-throughput

0.279

Low

1350300

C99L2
CD99 antigen-like protein 2

1

0

High-throughput

0.279

Low

1410684

APOL2
Apolipoprotein L2

1

0

High-throughput

0.279

Low

1417581

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

294469

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

844889

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025