Protein: 6PGD
6-phosphogluconate dehydrogenase, decarboxylating (EC 1.1.1.44)

Gene: 6PGD, PGD
Organism: Homo sapiens
Interactions: 99
UniProt ID: P52209

Gene Ontology (top 5):
GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006098 - pentose-phosphate shunt
GO:0009051 - pentose-phosphate shunt, oxidative branch

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

226924

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

397855

ISG15
Ubiquitin-like protein ISG15

2

4

High-throughput

0.584

High

852746

ACE2
Angiotensin-converting enzyme 2

2

1

High-throughput

0.584

High

166680

CE290
Centrosomal protein of 290 kDa

2

1

High-throughput

0.571

High

272525

OFD1
Centriole and centriolar satellite protein OFD1

2

1

High-throughput

0.571

High

346284

MYC
Myc proto-oncogene protein

2

2

High-throughput

0.571

High

596380

RASA1
Ras GTPase-activating protein 1

2

1

High-throughput

0.571

High

496608

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.536

High

734895

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

851394

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.536

High

852729

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

852740

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

852752

PAK6
Serine/threonine-protein kinase PAK 6

1

1

High-throughput

0.536

High

852759

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.536

High

852704

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

726098

BASI
Basigin

1

2

High-throughput

0.515

High

201273

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

852718

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

852728

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

852739

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

0

High-throughput

0.513

High

852747

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

174736

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

852708

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

852738

MYLK4
Myosin light chain kinase family member 4

1

2

High-throughput

0.489

High

321383

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

0

High-throughput

0.486

High

515381

CDK4
Cyclin-dependent kinase 4

1

2

High-throughput

0.481

High

129720

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

455245

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

552287

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

625254

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

650729

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

676654

AL1B1
Aldehyde dehydrogenase X, mitochondrial

1

1

High-throughput

0.479

High

740479

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.479

High

749258

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

799065

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

817817

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

852709

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

852711

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

852713

H4
Histone H4

1

1

High-throughput

0.479

High

852715

CAP1
Adenylyl cyclase-associated protein 1

1

1

High-throughput

0.479

High

852719

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

852720

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

852721

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.479

High

852722

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

852723

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

852726

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

2

High-throughput

0.479

High

852730

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

852741

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

852742

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

852744

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

852745

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

852751

DUS21
Dual specificity protein phosphatase 21

1

1

High-throughput

0.479

High

852756

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

852757

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

1

High-throughput

0.479

High

852758

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

243340

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.458

High

244149

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

272071

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

0

High-throughput

0.458

High

354373

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

393112

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

428102

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

503725

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

569430

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

591781

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.458

High

603406

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.458

High

779061

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

815197

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

815484

XDH
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

1

0

High-throughput

0.458

High

852707

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

852712

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

852714

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

852724

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

852735

CDC73
Parafibromin

1

0

High-throughput

0.458

High

852753

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

852754

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

852755

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

666562

LTK
Leukocyte tyrosine kinase receptor

1

1

High-throughput

0.457

High

717587

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

852732

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

852734

PKHA7
Pleckstrin homology domain-containing family A member 7

1

4

High-throughput

0.445

High

852717

GLGB
1,4-alpha-glucan-branching enzyme

1

0

High-throughput

0.438

High

720025

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

852731

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

852736

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

852743

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.437

High

852749

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

852750

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

528808

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

786282

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

852705

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

852725

KEAP1
Kelch-like ECH-associated protein 1

1

0

High-throughput

0.426

High

852737

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

852706

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

852733

USPL1
SUMO-specific isopeptidase USPL1

1

0

High-throughput

0.269

Low

329518

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

852716

CAV1
Caveolin-1

1

0

High-throughput

0.249

Low

852727

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

852710

SMS
Somatostatin

1

0

Small-scale

0.232

Low

852748

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024