Protein: TPD53
Tumor protein D53 (hD53) (Tumor protein D52-like 1)

Gene: TPD53, TPD52L1
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q16890

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0005737 - cytoplasm
GO:0042802 - identical protein binding
GO:0042803 - protein homodimerization activity
GO:0043406 - positive regulation of MAP kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

938059

TPD52
Tumor protein D52

5

13

Small-scale

0.715

High

215428

TPD54
Tumor protein D54

4

14

Small-scale

0.697

High

1164394

TPD55
Tumor protein D55

3

14

Small-scale

0.647

High

729875

1433B
14-3-3 protein beta/alpha

2

10

Small-scale

0.644

High

691053

1433T
14-3-3 protein theta

2

10

Small-scale

0.611

High

610348

PRS6A
26S proteasome regulatory subunit 6A

3

2

High-throughput

0.609

High

1164390

AZIN2
Antizyme inhibitor 2

2

0

High-throughput

0.602

High

1164400

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

2

1

High-throughput

0.601

High

990280

1433Z
14-3-3 protein zeta/delta

1

10

Small-scale

0.573

High

920447

DAPK1
Death-associated protein kinase 1

1

1

High-throughput

0.536

High

966372

1433G
14-3-3 protein gamma

1

10

High-throughput

0.536

High

1049334

1433F
14-3-3 protein eta

1

10

High-throughput

0.536

High

1109773

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.518

High

1164401

PAK6
Serine/threonine-protein kinase PAK 6

1

0

High-throughput

0.518

High

1164403

YAE1
Protein YAE1 homolog

1

0

High-throughput

0.518

High

1164398

EPN3
Epsin-3

1

0

High-throughput

0.513

High

1164405

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.513

High

1164384

TPD53
Tumor protein D53

1

14

Small-scale

0.508

High

248440

NMD3B
Glutamate receptor ionotropic, NMDA 3B

1

2

High-throughput

0.489

High

1164389

MAL2
Protein MAL2

1

1

Small-scale

0.481

High

1164388

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

1164395

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

2

Small-scale

0.479

High

1164391

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

730619

1433S
14-3-3 protein sigma

1

10

Small-scale

0.457

High

1110248

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

High-throughput

0.445

High

1110348

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

2

High-throughput

0.445

High

1110452

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

2

High-throughput

0.445

High

1160815

MAPK3
MAP kinase-activated protein kinase 3

1

1

High-throughput

0.445

High

1164397

RAB1B
Ras-related protein Rab-1B

1

4

High-throughput

0.445

High

823944

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

1164386

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.437

High

1164385

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

1164402

XPP1
Xaa-Pro aminopeptidase 1

1

0

High-throughput

0.426

High

1164404

LMCD1
LIM and cysteine-rich domains protein 1

1

0

High-throughput

0.426

High

225481

CYH3
Cytohesin-3

1

1

High-throughput

0.407

High

360192

GSHR
Glutathione reductase, mitochondrial

1

2

High-throughput

0.407

High

1164392

KCD12
BTB/POZ domain-containing protein KCTD12

2

0

High-throughput

0.313

High

295336

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.282

High

840964

ABL2
Tyrosine-protein kinase ABL2

1

0

High-throughput

0.282

High

1164387

GP135
G-protein coupled receptor 135

1

0

High-throughput

0.282

High

630286

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

0

High-throughput

0.279

Low

1013947

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.279

Low

1164396

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.279

Low

1164406

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

0

High-throughput

0.279

Low

571609

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.249

Low

405471

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.232

Low

916167

BIEA
Biliverdin reductase A

1

0

High-throughput

0.232

Low

1164393

PGM2
Phosphopentomutase

1

0

High-throughput

0.232

Low

1164399

AMPB
Aminopeptidase B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025