Protein: SPHK1
Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-)

Gene: SPHK1
Organism: Homo sapiens
Interactions: 86
UniProt ID: Q9NYA1

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001568 - blood vessel development
GO:0001727 - lipid kinase activity
GO:0003677 - DNA binding
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1278855

DCXR
L-xylulose reductase

4

1

Small-scale

0.691

High

1090951

TRAF2
TNF receptor-associated factor 2

3

3

Small-scale

0.664

High

1446973

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

3

0

High-throughput

0.638

High

1452421

TRAF6
TNF receptor-associated factor 6

2

3

Small-scale

0.601

High

881812

DHYS
Deoxyhypusine synthase

2

0

High-throughput

0.585

High

187198

PPM1G
Protein phosphatase 1G

2

3

Small-scale

0.571

High

1107277

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.561

High

1399938

KLHL5
Kelch-like protein 5

1

1

Small-scale

0.549

High

565539

RARG
Retinoic acid receptor gamma

1

2

High-throughput

0.541

High

996369

EF1A1
Elongation factor 1-alpha 1

1

0

Small-scale

0.537

High

1226601

MAP1S
Microtubule-associated protein 1S

1

1

High-throughput

0.536

High

1280975

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.536

High

1405808

TTC1
Tetratricopeptide repeat protein 1

1

1

High-throughput

0.536

High

1414653

TCAB1
Telomerase Cajal body protein 1

1

4

High-throughput

0.536

High

1452415

KLHL8
Kelch-like protein 8

1

1

High-throughput

0.536

High

1452419

MAN1
Inner nuclear membrane protein Man1

1

2

High-throughput

0.536

High

1452420

SHLB1
Endophilin-B1

1

1

High-throughput

0.515

High

848084

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

1017816

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.513

High

1180702

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.513

High

1191992

TBB8
Tubulin beta-8 chain

1

0

High-throughput

0.513

High

1244275

VIP1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

1

0

High-throughput

0.513

High

1336179

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.513

High

1392069

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.513

High

1415605

AFG2B
ATPase family gene 2 protein homolog B

1

0

High-throughput

0.513

High

1436841

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

0

High-throughput

0.513

High

1449117

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.513

High

1452418

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

1178966

SPKAP
A-kinase anchor protein SPHKAP

1

0

Small-scale

0.506

High

1123150

FHL2
Four and a half LIM domains protein 2

1

3

Small-scale

0.506

High

440754

FYN
Tyrosine-protein kinase Fyn

1

4

Small-scale

0.501

High

1067774

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.501

High

562449

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

1349382

RDH11
Retinol dehydrogenase 11

1

2

High-throughput

0.489

High

1402168

KS6C1
Ribosomal protein S6 kinase delta-1

1

1

Small-scale

0.479

High

1126773

BECN1
Beclin-1

1

0

Small-scale

0.458

High

1131492

MBTP1
Membrane-bound transcription factor site-1 protease

1

1

Small-scale

0.457

High

123853

MYO1C
Unconventional myosin-Ic

1

3

Small-scale

0.445

High

130800

TAF4
Transcription initiation factor TFIID subunit 4

1

1

Small-scale

0.445

High

157925

CTRO
Citron Rho-interacting kinase

1

1

Small-scale

0.445

High

227989

MYO1B
Unconventional myosin-Ib

1

3

Small-scale

0.445

High

270852

ROCK2
Rho-associated protein kinase 2

1

1

Small-scale

0.445

High

318405

MYO1D
Unconventional myosin-Id

1

3

Small-scale

0.445

High

405350

OAT
Ornithine aminotransferase, mitochondrial

1

1

Small-scale

0.445

High

637161

CSRP1
Cysteine and glycine-rich protein 1

1

1

Small-scale

0.445

High

650990

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

4

Small-scale

0.445

High

882926

EFTU
Elongation factor Tu, mitochondrial

1

1

Small-scale

0.445

High

887731

PSB2
Proteasome subunit beta type-2

1

1

Small-scale

0.445

High

953142

ACTB
Actin, cytoplasmic 1

1

1

Small-scale

0.445

High

987981

GRB2
Growth factor receptor-bound protein 2

1

5

Small-scale

0.445

High

993354

ACTG
Actin, cytoplasmic 2

1

1

Small-scale

0.445

High

1023294

RBM3
RNA-binding protein 3

1

1

Small-scale

0.445

High

1160776

DREB
Drebrin

1

1

Small-scale

0.445

High

1212246

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

8

Small-scale

0.445

High

1241049

L2GL2
LLGL scribble cell polarity complex component 2

1

1

Small-scale

0.445

High

1280557

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

4

Small-scale

0.445

High

1407917

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.445

High

1410815

AIF1L
Allograft inflammatory factor 1-like

1

2

Small-scale

0.445

High

179573

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

Small-scale

0.426

High

255700

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

Small-scale

0.426

High

336496

SVIL
Supervillin

1

0

Small-scale

0.426

High

346420

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

Small-scale

0.426

High

347374

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

538016

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.426

High

681533

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.426

High

701083

PSB6
Proteasome subunit beta type-6

1

0

Small-scale

0.426

High

773049

MYH9
Myosin-9

1

0

Small-scale

0.426

High

878347

MRP
MARCKS-related protein

1

0

Small-scale

0.426

High

903649

GALK1
Galactokinase

1

0

Small-scale

0.426

High

955863

DEST
Destrin

1

0

Small-scale

0.426

High

991110

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

Small-scale

0.426

High

1094275

ACACA
Acetyl-CoA carboxylase 1

1

0

Small-scale

0.426

High

1099797

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.426

High

1108216

SQSTM
Sequestosome-1

1

0

Small-scale

0.426

High

1145135

RAB35
Ras-related protein Rab-35

1

0

Small-scale

0.426

High

1210544

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

Small-scale

0.426

High

1346591

PSMA8
Proteasome subunit alpha-type 8

1

0

Small-scale

0.426

High

1409694

ARP5L
Actin-related protein 2/3 complex subunit 5-like protein

1

0

Small-scale

0.426

High

1452416

ARMX3
Armadillo repeat-containing X-linked protein 3

1

0

Small-scale

0.426

High

1452417

DPP2
Dipeptidyl peptidase 2

1

0

Small-scale

0.426

High

1230812

ANR40
Ankyrin repeat domain-containing protein 40

1

0

High-throughput

0.279

Low

139085

LAD1
Ladinin-1

1

0

Small-scale

0.232

Low

460885

CATB
Cathepsin B

1

0

Small-scale

0.232

Low

1132066

LTBP1
Latent-transforming growth factor beta-binding protein 1

1

0

Small-scale

0.232

Low

1163710

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

0

Small-scale

0.232

Low

1452414

TMOD3
Tropomodulin-3

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025