Protein: WLS
Protein wntless homolog (Integral membrane protein GPR177) (Protein evenness interrupted homolog) (EVI) (Putative NF-kappa-B-activating protein 373)

Gene: WLS
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q5T9L3

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001707 - mesoderm formation
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135861

WNT7A
Protein Wnt-7a

3

20

Small-scale

0.861

High

782089

WNT5A
Protein Wnt-5a

3

20

Small-scale

0.861

High

881881

WNT4
Protein Wnt-4

3

20

High-throughput

0.861

High

881860

WNT3A
Protein Wnt-3a

3

20

Small-scale

0.850

High

723049

OPRM
Mu-type opioid receptor

4

6

Small-scale

0.712

High

1135451

WNT16
Protein Wnt-16

1

20

High-throughput

0.691

High

1135417

5HT3C
5-hydroxytryptamine receptor 3C

3

3

High-throughput

0.667

High

446028

CD63
CD63 antigen

3

4

Small-scale

0.656

High

1135402

WLS
Protein wntless homolog

2

1

Small-scale

0.634

High

802333

5HT3A
5-hydroxytryptamine receptor 3A

2

4

High-throughput

0.628

High

989619

ACHD
Acetylcholine receptor subunit delta

2

2

High-throughput

0.628

High

451998

WNT2
Protein Wnt-2

1

20

High-throughput

0.618

High

384072

WNT1
Proto-oncogene Wnt-1

1

20

Small-scale

0.618

High

881899

WNT7B
Protein Wnt-7b

1

20

Small-scale

0.618

High

1135437

WNT8A
Protein Wnt-8a

1

20

Small-scale

0.618

High

1135438

WNT5B
Protein Wnt-5b

1

20

Small-scale

0.618

High

664342

AA2AR
Adenosine receptor A2a

2

4

Small-scale

0.601

High

1135453

CLC4E
C-type lectin domain family 4 member E

2

0

High-throughput

0.595

High

968116

SC6A3
Sodium-dependent dopamine transporter

2

0

Small-scale

0.585

High

350235

RASK
GTPase KRas

2

4

High-throughput

0.584

High

915738

RHOB
Rho-related GTP-binding protein RhoB

2

2

High-throughput

0.584

High

1068261

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

Small-scale

0.575

High

296204

DPM2
Dolichol phosphate-mannose biosynthesis regulatory protein

2

0

Small-scale

0.559

High

876219

AQP4
Aquaporin-4

2

0

Small-scale

0.559

High

1135408

PIGW
Phosphatidylinositol-glycan biosynthesis class W protein

2

0

Small-scale

0.559

High

1135421

TM230
Transmembrane protein 230

2

0

Small-scale

0.559

High

1135428

YIPF6
Protein YIPF6

2

0

Small-scale

0.559

High

1135443

TM134
Transmembrane protein 134

2

0

Small-scale

0.559

High

1135444

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

2

0

Small-scale

0.559

High

1135449

CNIH4
Protein cornichon homolog 4

2

0

Small-scale

0.559

High

1135454

PCDBA
Protocadherin beta-10

2

0

Small-scale

0.559

High

1135457

TM14A
Transmembrane protein 14A

2

0

Small-scale

0.559

High

158068

WNT9A
Protein Wnt-9a

1

20

Small-scale

0.553

High

158076

WNT9B
Protein Wnt-9b

1

20

Small-scale

0.553

High

1135420

WNT8B
Protein Wnt-8b

1

20

Small-scale

0.553

High

176031

GPR37
Prosaposin receptor GPR37

1

4

High-throughput

0.541

High

537287

DRD2
D(2) dopamine receptor

1

5

High-throughput

0.541

High

722996

HRH1
Histamine H1 receptor

1

5

High-throughput

0.541

High

783823

CCR2
C-C chemokine receptor type 2

1

5

High-throughput

0.541

High

156839

FFAR1
Free fatty acid receptor 1

1

6

High-throughput

0.536

High

172031

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

506327

ACHB
Acetylcholine receptor subunit beta

1

2

High-throughput

0.536

High

519409

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

1

High-throughput

0.536

High

713670

GBRA3
Gamma-aminobutyric acid receptor subunit alpha-3

1

1

High-throughput

0.536

High

798492

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

1

High-throughput

0.536

High

1135416

TMED6
Transmembrane emp24 domain-containing protein 6

1

1

High-throughput

0.536

High

1135456

SNX8
Sorting nexin-8

1

1

High-throughput

0.536

High

1135432

SMO
Protein smoothened

1

0

High-throughput

0.518

High

781041

OPRK
Kappa-type opioid receptor

1

5

Small-scale

0.515

High

654421

CALX
Calnexin

1

0

High-throughput

0.513

High

686307

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.513

High

833239

TMEDA
Transmembrane emp24 domain-containing protein 10

1

0

High-throughput

0.513

High

1092758

DOXA2
Dual oxidase maturation factor 2

1

0

High-throughput

0.513

High

1135404

STYK1
Tyrosine-protein kinase STYK1

1

0

High-throughput

0.513

High

1135412

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1135418

NICA
Nicastrin

1

0

High-throughput

0.513

High

1135442

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1135434

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

1

Small-scale

0.506

High

1135445

TMPS4
Transmembrane protease serine 4

1

0

High-throughput

0.493

High

849554

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

Small-scale

0.484

High

348714

RASN
GTPase NRas

1

4

High-throughput

0.479

High

349387

RASH
GTPase HRas

1

2

High-throughput

0.479

High

436351

RHOC
Rho-related GTP-binding protein RhoC

1

2

High-throughput

0.479

High

591877

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.479

High

592304

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

781024

OPRD
Delta-type opioid receptor

1

5

Small-scale

0.479

High

793346

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

844563

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.479

High

845528

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

895120

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

900566

RHOA
Transforming protein RhoA

1

2

High-throughput

0.479

High

1135413

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1135415

RN128
E3 ubiquitin-protein ligase RNF128

1

1

High-throughput

0.479

High

1135419

UBXN4
UBX domain-containing protein 4

1

1

Small-scale

0.479

High

1135425

FAF2
FAS-associated factor 2

1

1

Small-scale

0.479

High

163840

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

167937

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

205504

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

299916

ERLN2
Erlin-2

1

0

Small-scale

0.458

High

390285

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390949

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

455534

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

828788

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.458

High

875013

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

890199

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

912948

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

1017664

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1070235

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1135403

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

1135406

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1135409

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1135411

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.458

High

1135422

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1135430

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1135431

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

1135436

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1135439

PORCN
Protein-serine O-palmitoleoyltransferase porcupine

1

0

Small-scale

0.458

High

1135440

GOLP3
Golgi phosphoprotein 3

1

0

Small-scale

0.458

High

1135450

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.458

High

1135455

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.458

High

330780

PX11B
Peroxisomal membrane protein 11B

1

0

Small-scale

0.438

High

536529

IRF2
Interferon regulatory factor 2

1

0

Small-scale

0.438

High

601275

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

Small-scale

0.438

High

965196

CAP1
Adenylyl cyclase-associated protein 1

1

0

Small-scale

0.438

High

1135407

ALKMO
Alkylglycerol monooxygenase

1

0

Small-scale

0.438

High

1135414

KMT2C
Histone-lysine N-methyltransferase 2C

1

0

Small-scale

0.438

High

1135427

ORAI1
Calcium release-activated calcium channel protein 1

1

0

Small-scale

0.438

High

1135441

RNF41
E3 ubiquitin-protein ligase NRDP1

1

0

Small-scale

0.438

High

1135405

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1135429

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1135426

F241B
Protein FAM241B

2

0

Small-scale

0.313

High

818809

SOX9
Transcription factor SOX-9

2

0

Small-scale

0.304

High

1134329

ZFAS1
Uncharacterized protein ZNF22-AS1

2

0

Small-scale

0.304

High

1135424

TOM6
Mitochondrial import receptor subunit TOM6 homolog

2

0

Small-scale

0.304

High

1135447

TM160
Transmembrane protein 160

2

0

Small-scale

0.304

High

1135448

TV23B
Golgi apparatus membrane protein TVP23 homolog B

2

0

Small-scale

0.304

High

1135410

S22A9
Organic anion transporter 7

1

0

High-throughput

0.279

Low

1135446

RPRM
Protein reprimo

1

0

High-throughput

0.279

Low

1135423

BORC7
BLOC-1-related complex subunit 7

1

0

Small-scale

0.257

Low

1135435

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

0

Small-scale

0.249

Low

1135433

CG025
UPF0415 protein C7orf25

1

0

Small-scale

0.238

Low

1135452

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

Small-scale

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024