Protein: MPRD
Cation-dependent mannose-6-phosphate receptor (CD Man-6-P receptor) (CD-MPR) (46 kDa mannose 6-phosphate receptor) (MPR 46)

Gene: MPRD, M6PR
Organism: Homo sapiens
Interactions: 63
UniProt ID: P20645

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0005765 - lysosomal membrane
GO:0005768 - endosome
GO:0005770 - late endosome
GO:0005802 - trans-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633875

GGA1
ADP-ribosylation factor-binding protein GGA1

2

2

Small-scale

0.632

High

253050

PLIN3
Perilipin-3

2

0

Small-scale

0.609

High

633871

GGA3
ADP-ribosylation factor-binding protein GGA3

2

2

Small-scale

0.594

High

633855

KTN1
Kinectin

2

0

High-throughput

0.580

High

633862

GIMA5
GTPase IMAP family member 5

2

0

High-throughput

0.580

High

633869

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.580

High

633872

NINJ2
Ninjurin-2

2

0

High-throughput

0.580

High

633863

TAFA4
Chemokine-like protein TAFA-4

2

2

High-throughput

0.574

High

633877

DUS12
Dual specificity protein phosphatase 12

2

1

High-throughput

0.553

High

633839

CALX
Calnexin

1

1

High-throughput

0.536

High

633861

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.515

High

633876

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.515

High

189417

STX7
Syntaxin-7

1

0

High-throughput

0.513

High

541333

FGFR1
Fibroblast growth factor receptor 1

1

2

High-throughput

0.500

High

633836

FGFR2
Fibroblast growth factor receptor 2

1

3

High-throughput

0.500

High

633845

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

2

High-throughput

0.500

High

633848

NTRK3
NT-3 growth factor receptor

1

2

High-throughput

0.500

High

633837

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.493

High

633853

TAFA1
Chemokine-like protein TAFA-1

1

2

High-throughput

0.489

High

633858

TAFA2
Chemokine-like protein TAFA-2

1

2

High-throughput

0.489

High

633874

GGA2
ADP-ribosylation factor-binding protein GGA2

1

2

Small-scale

0.481

High

136827

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

217821

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

240733

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

362756

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

390459

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

467368

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

536482

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

633415

ANPRB
Atrial natriuretic peptide receptor 2

1

0

High-throughput

0.458

High

633835

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.458

High

633842

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

633847

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.458

High

633870

DJB12
DnaJ homolog subfamily B member 12

1

0

High-throughput

0.458

High

633873

CLC2D
C-type lectin domain family 2 member D

1

2

High-throughput

0.445

High

211113

CTR4
Cationic amino acid transporter 4

1

0

High-throughput

0.426

High

388370

B3AT
Band 3 anion transport protein

1

0

High-throughput

0.426

High

633843

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.426

High

633846

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

633849

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.426

High

633851

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

633856

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.426

High

633857

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.426

High

633859

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.426

High

633867

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

633878

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

170657

CLGN
Calmegin

1

1

High-throughput

0.407

High

633860

PATE1
Prostate and testis expressed protein 1

2

0

High-throughput

0.313

High

633841

ARL3
ADP-ribosylation factor-like protein 3

1

0

High-throughput

0.279

Low

633866

SG196
Protein O-mannose kinase

1

0

High-throughput

0.279

Low

212930

HS12A
Heat shock 70 kDa protein 12A

1

0

Small-scale

0.265

Low

587901

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

633838

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

633840

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

633844

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

633852

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

633854

RHG30
Rho GTPase-activating protein 30

1

0

High-throughput

0.249

Low

633864

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.249

Low

633865

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

633868

FBX6
F-box only protein 6

1

0

High-throughput

0.249

Low

286521

SG2A1
Mammaglobin-B

1

0

High-throughput

0.232

Low

547965

PSPC
Surfactant protein C

1

0

High-throughput

0.232

Low

633850

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.232

Low

429290

JUN
Transcription factor Jun

1

0

Small-scale

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025