Protein: PFD1
Prefoldin subunit 1

Gene: PFD1, PFDN1
Organism: Homo sapiens
Interactions: 169
UniProt ID: O60925

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0005737 - cytoplasm
GO:0006457 - protein folding
GO:0016272 - prefoldin complex
GO:0044183 - protein folding chaperone

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

261858

PFD5
Prefoldin subunit 5

10

1

Small-scale

0.968

High

261890

PFD2
Prefoldin subunit 2

7

1

Small-scale

0.957

High

182061

PFD6
Prefoldin subunit 6

4

1

High-throughput

0.892

High

261784

PFD3
Prefoldin subunit 3

4

1

High-throughput

0.892

High

261880

PFD4
Prefoldin subunit 4

4

1

High-throughput

0.892

High

261881

PDRG1
p53 and DNA damage-regulated protein 1

2

0

High-throughput

0.736

High

261769

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.691

High

261774

TCPQ
T-complex protein 1 subunit theta

1

3

High-throughput

0.691

High

261775

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.691

High

261793

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.691

High

261863

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.691

High

261832

TBA1A
Tubulin alpha-1A chain

4

2

Small-scale

0.683

High

261889

AAKG3
5'-AMP-activated protein kinase subunit gamma-3

4

0

High-throughput

0.670

High

261789

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

5

High-throughput

0.667

High

261855

DCAF5
DDB1- and CUL4-associated factor 5

3

4

High-throughput

0.662

High

261797

MK07
Mitogen-activated protein kinase 7

4

0

High-throughput

0.661

High

261867

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

3

4

High-throughput

0.650

High

261897

GIT1
ARF GTPase-activating protein GIT1

4

1

High-throughput

0.637

High

261871

SKI8
Superkiller complex protein 8

2

5

High-throughput

0.628

High

261800

HDAC1
Histone deacetylase 1

3

0

High-throughput

0.622

High

261772

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.618

High

261788

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

5

High-throughput

0.601

High

261801

ARHG7
Rho guanine nucleotide exchange factor 7

2

1

High-throughput

0.601

High

261817

DCAF6
DDB1- and CUL4-associated factor 6

2

5

High-throughput

0.601

High

261884

NALP2
NACHT, LRR and PYD domains-containing protein 2

2

1

High-throughput

0.601

High

261879

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

261745

TACC1
Transforming acidic coiled-coil-containing protein 1

2

0

High-throughput

0.576

High

261754

TYSY
Thymidylate synthase

2

0

High-throughput

0.576

High

261778

AF10
Protein AF-10

2

1

High-throughput

0.549

High

261802

GIT2
ARF GTPase-activating protein GIT2

2

1

High-throughput

0.549

High

261746

KTNA1
Katanin p60 ATPase-containing subunit A1

1

2

High-throughput

0.536

High

261785

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.536

High

261791

TBA1B
Tubulin alpha-1B chain

1

2

High-throughput

0.536

High

261807

ARHG6
Rho guanine nucleotide exchange factor 6

1

1

High-throughput

0.536

High

261841

NEDD1
Protein NEDD1

1

5

High-throughput

0.536

High

261868

KATL1
Katanin p60 ATPase-containing subunit A-like 1

1

2

High-throughput

0.536

High

130898

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.518

High

261755

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.518

High

261795

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.518

High

261886

CE126
Centrosomal protein of 126 kDa

1

0

High-throughput

0.518

High

261887

WRP73
WD repeat-containing protein WRAP73

1

5

High-throughput

0.515

High

261744

ROCK2
Rho-associated protein kinase 2

1

0

High-throughput

0.513

High

261766

MOES
Moesin

1

0

High-throughput

0.513

High

261792

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.513

High

261833

KI21A
Kinesin-like protein KIF21A

1

0

High-throughput

0.513

High

261859

PKP4
Plakophilin-4

1

0

High-throughput

0.513

High

261874

PDCL3
Phosducin-like protein 3

1

0

High-throughput

0.513

High

261824

JADE1
Protein Jade-1

1

1

High-throughput

0.508

High

261776

HAP1
Huntingtin-associated protein 1

1

1

High-throughput

0.494

High

209166

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

6

High-throughput

0.489

High

261827

TRAF7
E3 ubiquitin-protein ligase TRAF7

1

3

High-throughput

0.489

High

261834

WDR86
WD repeat-containing protein 86

1

6

High-throughput

0.489

High

261846

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.489

High

261854

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.489

High

261885

DTL
Denticleless protein homolog

1

3

High-throughput

0.489

High

223966

GET3
ATPase GET3

1

0

High-throughput

0.486

High

261748

SC31A
Protein transport protein Sec31A

1

0

High-throughput

0.486

High

261752

ALBU
Albumin

1

0

High-throughput

0.486

High

261779

SUMO3
Small ubiquitin-related modifier 3

1

0

High-throughput

0.486

High

261787

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.486

High

261804

DCTN1
Dynactin subunit 1

1

0

High-throughput

0.486

High

261822

MYOME
Myomegalin

1

0

High-throughput

0.486

High

261866

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.486

High

261870

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.486

High

261873

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

0

High-throughput

0.486

High

156576

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

3

High-throughput

0.479

High

261751

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

261753

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

261764

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.479

High

261780

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

261782

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

261799

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

3

High-throughput

0.479

High

261803

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

261825

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

High-throughput

0.479

High

261840

POC1A
POC1 centriolar protein homolog A

1

5

High-throughput

0.479

High

261842

POC1B
POC1 centriolar protein homolog B

1

5

High-throughput

0.479

High

261843

GEMI5
Gem-associated protein 5

1

4

High-throughput

0.479

High

261893

PRP19
Pre-mRNA-processing factor 19

1

5

High-throughput

0.479

High

261894

FBW1A
F-box/WD repeat-containing protein 1A

1

3

High-throughput

0.479

High

261900

YTHD2
YTH domain-containing family protein 2

1

2

High-throughput

0.479

High

163869

NDC80
Kinetochore protein NDC80 homolog

1

1

High-throughput

0.464

High

261757

COT1
COUP transcription factor 1

1

1

High-throughput

0.464

High

47933

RBM47
RNA-binding protein 47

1

0

High-throughput

0.458

High

261747

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

261786

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

261809

RNPS1
RNA-binding protein with serine-rich domain 1

1

0

High-throughput

0.458

High

261812

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

261826

SKI3
Superkiller complex protein 3

1

0

High-throughput

0.458

High

261830

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

261844

SMAP2
Stromal membrane-associated protein 2

1

0

High-throughput

0.458

High

261848

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

261851

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.458

High

261862

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

0

High-throughput

0.458

High

261864

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.458

High

261869

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

0

High-throughput

0.458

High

261875

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

261883

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

261888

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

261815

DC4L1
DDB1- and CUL4-associated factor 4-like protein 1

1

1

High-throughput

0.445

High

261821

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

253222

REV3L
DNA polymerase zeta catalytic subunit

1

1

High-throughput

0.437

High

261756

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.437

High

261781

FBXW4
F-box/WD repeat-containing protein 4

1

5

Small-scale

0.437

High

261794

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

1

High-throughput

0.437

High

261798

ERCC8
DNA excision repair protein ERCC-8

1

4

Small-scale

0.437

High

261891

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.437

High

261892

ALK
ALK tyrosine kinase receptor

1

1

High-throughput

0.437

High

261758

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

261762

BGAL
Beta-galactosidase

1

0

High-throughput

0.426

High

261777

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

261847

DDB2
DNA damage-binding protein 2

1

6

High-throughput

0.407

High

261896

KLDC2
Kelch domain-containing protein 2

2

0

High-throughput

0.328

High

261813

MIC60
MICOS complex subunit MIC60

2

0

High-throughput

0.323

High

67590

RHG32
Rho GTPase-activating protein 32

2

0

High-throughput

0.313

High

261852

ESPB1
Epididymal sperm-binding protein 1

2

0

High-throughput

0.313

High

261872

MFR1L
Mitochondrial fission regulator 1-like

2

0

High-throughput

0.313

High

261878

RC3H2
Roquin-2

2

0

High-throughput

0.313

High

261837

ARG39
Rho guanine nucleotide exchange factor 39

2

0

High-throughput

0.298

High

261898

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.282

High

261816

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.279

Low

261829

NEK10
Serine/threonine-protein kinase Nek10

1

0

High-throughput

0.279

Low

261831

LARP4
La-related protein 4

1

0

High-throughput

0.279

Low

261839

DB123
Beta-defensin 123

1

0

High-throughput

0.279

Low

261860

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

0

High-throughput

0.279

Low

261865

SPI2B
Spindlin-2B

1

0

High-throughput

0.279

Low

261895

PKHA6
Pleckstrin homology domain-containing family A member 6

1

0

High-throughput

0.279

Low

175284

PLXB2
Plexin-B2

1

0

High-throughput

0.265

Low

261750

EOMES
Eomesodermin homolog

1

0

High-throughput

0.265

Low

261759

CMGA
Chromogranin-A

1

0

High-throughput

0.265

Low

261760

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

0

High-throughput

0.265

Low

261761

HXD8
Homeobox protein Hox-D8

1

0

High-throughput

0.265

Low

261763

PTN
Pleiotrophin

1

0

High-throughput

0.265

Low

261796

HMGX3
HMG domain-containing protein 3

1

0

High-throughput

0.265

Low

261805

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.265

Low

261806

ZN235
Zinc finger protein 235

1

0

High-throughput

0.265

Low

261811

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.265

Low

261814

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.265

Low

261819

TTC38
Tetratricopeptide repeat protein 38

1

0

High-throughput

0.265

Low

261828

K0408
Uncharacterized protein KIAA0408

1

0

High-throughput

0.265

Low

261835

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.265

Low

261845

BRK1
Protein BRICK1

1

0

High-throughput

0.265

Low

261849

EXT2
Exostosin-2

1

0

High-throughput

0.265

Low

261853

ESS2
Splicing factor ESS-2 homolog

1

0

High-throughput

0.265

Low

261856

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.265

Low

261857

IF140
Intraflagellar transport protein 140 homolog

1

0

High-throughput

0.265

Low

261861

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.265

Low

261877

RMI1
RecQ-mediated genome instability protein 1

1

0

High-throughput

0.265

Low

261901

SNX5
Sorting nexin-5

1

0

High-throughput

0.265

Low

261790

ACTS
Actin, alpha skeletal muscle

1

0

Small-scale

0.261

Low

162885

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.251

Low

261749

YETS4
YEATS domain-containing protein 4

1

0

Small-scale

0.251

Low

261818

GASP1
G-protein coupled receptor-associated sorting protein 1

1

0

High-throughput

0.251

Low

261820

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

261765

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.249

Low

261767

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.249

Low

261770

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.249

Low

261771

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.249

Low

261808

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

261810

SKI2
Superkiller complex protein 2

1

0

High-throughput

0.249

Low

261836

YAF2
YY1-associated factor 2

1

0

High-throughput

0.249

Low

261838

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

261882

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

261899

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low

261783

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.238

Low

261850

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.238

Low

261876

SYNG1
Synapse differentiation-inducing gene protein 1

1

0

High-throughput

0.238

Low

261768

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.232

Low

261823

DC122
DDB1- and CUL4-associated factor 12-like protein 2

1

0

High-throughput

0.232

Low

261773

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.213

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025