Protein: FBX5
F-box only protein 5 (Early mitotic inhibitor 1)

Gene: FBX5, FBXO5
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q9UKT4

Gene Ontology (top 5):
GO:0001556 - oocyte maturation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992386

SKP1
S-phase kinase-associated protein 1

13

1

Small-scale

0.979

High

1460774

ANC2
Anaphase-promoting complex subunit 2

5

4

Small-scale

0.928

High

1112783

CUL1
Cullin-1

4

1

Small-scale

0.873

High

1461214

FZR1
Fizzy-related protein homolog

9

6

Small-scale

0.755

High

718658

CDC27
Cell division cycle protein 27 homolog

8

7

Small-scale

0.750

High

1461216

FBW1A
F-box/WD repeat-containing protein 1A

9

2

Small-scale

0.750

High

1093084

CDC16
Cell division cycle protein 16 homolog

5

7

Small-scale

0.723

High

1460725

CDC23
Cell division cycle protein 23 homolog

5

7

Small-scale

0.721

High

1460766

APC4
Anaphase-promoting complex subunit 4

5

0

Small-scale

0.689

High

1460999

FBW1B
F-box/WD repeat-containing protein 11

4

2

Small-scale

0.672

High

1086935

CDC20
Cell division cycle protein 20 homolog

3

6

Small-scale

0.664

High

1340923

CDC26
Anaphase-promoting complex subunit CDC26

4

0

High-throughput

0.658

High

1162721

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.656

High

1452596

APC11
Anaphase-promoting complex subunit 11

1

2

Small-scale

0.647

High

1460757

APC5
Anaphase-promoting complex subunit 5

3

0

Small-scale

0.642

High

1387383

APC16
Anaphase-promoting complex subunit 16

3

0

High-throughput

0.634

High

920352

PLK1
Serine/threonine-protein kinase PLK1

3

4

Small-scale

0.633

High

1460748

APC7
Anaphase-promoting complex subunit 7

2

7

Small-scale

0.624

High

1461215

APC10
Anaphase-promoting complex subunit 10

2

3

Small-scale

0.619

High

1114621

CUL3
Cullin-3

1

1

High-throughput

0.618

High

1430914

APC1
Anaphase-promoting complex subunit 1

2

0

Small-scale

0.612

High

948608

APC15
Anaphase-promoting complex subunit 15

2

0

High-throughput

0.602

High

1412131

APC13
Anaphase-promoting complex subunit 13

2

0

High-throughput

0.602

High

1382399

SPSB4
SPRY domain-containing SOCS box protein 4

2

1

High-throughput

0.601

High

249015

EVI5
Ecotropic viral integration site 5 protein homolog

1

0

Small-scale

0.564

High

1056001

RAD51
DNA repair protein RAD51 homolog 1

1

0

Small-scale

0.537

High

447893

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.518

High

238967

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.513

High

1406276

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.513

High

1415641

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.513

High

1433117

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.513

High

443555

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.501

High

557515

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

Small-scale

0.480

High

284360

GEMI
Geminin

1

0

Small-scale

0.479

High

799567

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.479

High

984021

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

Small-scale

0.479

High

1388659

SPDLY
Protein Spindly

1

1

High-throughput

0.479

High

166583

BACH1
Transcription regulator protein BACH1

1

0

Small-scale

0.458

High

174635

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.458

High

376078

RASK
GTPase KRas

1

0

High-throughput

0.458

High

459795

PROF1
Profilin-1

1

0

High-throughput

0.458

High

953174

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

1406803

BARD1
BRCA1-associated RING domain protein 1

1

0

Small-scale

0.458

High

1418510

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

1419324

TRI55
Tripartite motif-containing protein 55

1

0

High-throughput

0.458

High

1195422

Q4KMX6
Anaphase-promoting complex subunit 7

1

7

High-throughput

0.407

High

643130

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025