Protein: DEK
Protein DEK

Gene: DEK
Organism: Homo sapiens
Interactions: 167
UniProt ID: P35659

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

775643

H4
Histone H4

3

1

Small-scale

0.847

High

227405

SPOP
Speckle-type POZ protein

6

1

Small-scale

0.735

High

775647

CSK21
Casein kinase II subunit alpha

4

5

High-throughput

0.702

High

625225

CSK22
Casein kinase II subunit alpha'

4

5

High-throughput

0.699

High

775648

H31
Histone H3.1

5

4

Small-scale

0.699

High

259539

BRD4
Bromodomain-containing protein 4

3

3

High-throughput

0.640

High

775704

H2B1H
Histone H2B type 1-H

2

3

High-throughput

0.601

High

324598

HEXI1
Protein HEXIM1

2

0

High-throughput

0.585

High

775731

DAXX
Death domain-associated protein 6

2

0

Small-scale

0.585

High

371333

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

674094

BRD2
Bromodomain-containing protein 2

2

4

High-throughput

0.584

High

775644

H2B1C
Histone H2B type 1-C/E/F/G/I

2

3

High-throughput

0.584

High

65902

RHG42
Rho GTPase-activating protein 42

2

1

High-throughput

0.571

High

775675

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

3

High-throughput

0.571

High

775687

RHG24
Rho GTPase-activating protein 24

2

2

High-throughput

0.571

High

775730

RHG20
Rho GTPase-activating protein 20

2

2

High-throughput

0.571

High

240918

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

385509

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

2

0

High-throughput

0.559

High

775728

KIF15
Kinesin-like protein KIF15

2

2

Small-scale

0.549

High

775630

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.536

High

775682

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

775710

ARHGQ
Rho guanine nucleotide exchange factor 26

2

1

High-throughput

0.521

High

238868

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

1

High-throughput

0.515

High

775639

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

1

High-throughput

0.515

High

775727

KI13B
Kinesin-like protein KIF13B

1

2

High-throughput

0.515

High

140778

NOP56
Nucleolar protein 56

1

0

High-throughput

0.513

High

210245

PHF1
PHD finger protein 1

1

0

High-throughput

0.513

High

693564

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

775655

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

775698

HDAC2
Histone deacetylase 2

1

0

Small-scale

0.513

High

775703

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

775713

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

775724

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

775726

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.513

High

185481

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

775638

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

775656

EP300
Histone acetyltransferase p300

1

3

Small-scale

0.501

High

775699

CBP
CREB-binding protein

1

3

Small-scale

0.501

High

775701

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.501

High

775677

ULK3
Serine/threonine-protein kinase ULK3

1

2

High-throughput

0.489

High

775708

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.481

High

775718

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.481

High

395604

ESR1
Estrogen receptor

1

0

High-throughput

0.479

High

142868

NFIB
Nuclear factor 1 B-type

1

1

High-throughput

0.479

High

172517

XPO1
Exportin-1

1

1

High-throughput

0.479

High

254335

CC14B
Dual specificity protein phosphatase CDC14B

1

1

High-throughput

0.479

High

277579

H2AY
Core histone macro-H2A.1

1

2

Small-scale

0.479

High

285113

EED
Polycomb protein EED

1

3

High-throughput

0.479

High

330711

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

400391

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

405849

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

473823

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

536623

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

588057

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606336

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

730419

1433S
14-3-3 protein sigma

1

2

Small-scale

0.479

High

775629

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

775631

CENPA
Histone H3-like centromeric protein A

1

4

High-throughput

0.479

High

775634

HDGF
Hepatoma-derived growth factor

1

2

High-throughput

0.479

High

775637

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

775640

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

775645

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

775646

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.479

High

775649

H33
Histone H3.3

1

4

High-throughput

0.479

High

775653

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

775658

FOXC1
Forkhead box protein C1

1

1

High-throughput

0.479

High

775659

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

775661

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

775663

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.479

High

775665

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

775667

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

775668

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

775669

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

775671

H2A2C
Histone H2A type 2-C

1

2

Small-scale

0.479

High

775672

H2B2E
Histone H2B type 2-E

1

3

Small-scale

0.479

High

775676

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

2

High-throughput

0.479

High

775680

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

775686

SRRM1
Serine/arginine repetitive matrix protein 1

1

1

Small-scale

0.479

High

775694

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

775696

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

775700

KAT6A
Histone acetyltransferase KAT6A

1

1

Small-scale

0.479

High

775705

FBXW7
F-box/WD repeat-containing protein 7

1

2

Small-scale

0.479

High

775716

H2A1J
Histone H2A type 1-J

1

2

High-throughput

0.479

High

775733

BAZ1B
Tyrosine-protein kinase BAZ1B

1

6

Small-scale

0.479

High

125281

LEG9
Galectin-9

1

0

High-throughput

0.458

High

128814

MEN1
Menin

1

0

High-throughput

0.458

High

164268

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

188824

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

222770

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

238413

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

247708

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

319465

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345448

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

431522

AP2A
Transcription factor AP-2-alpha

1

0

Small-scale

0.458

High

446711

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

472489

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

667593

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

694772

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

765184

BMI1
Polycomb complex protein BMI-1

1

0

Small-scale

0.458

High

767553

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

775633

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

775635

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.458

High

775636

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

775641

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

775642

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

775651

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

775652

H11
Histone H1.1

1

0

Small-scale

0.458

High

775654

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.458

High

775657

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

775662

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

775666

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

775673

MIDN
Midnolin

1

0

High-throughput

0.458

High

775679

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

775684

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.458

High

775685

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

775691

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

775695

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

775702

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

775706

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

775707

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

775709

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

775712

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

775720

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

775722

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

775729

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

775732

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

775734

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.458

High

775736

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

354570

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

429414

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

775660

STF1
Steroidogenic factor 1

1

3

Small-scale

0.445

High

271946

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

488729

FURIN
Furin

1

1

High-throughput

0.437

High

775674

DDX6L
Probable ATP-dependent RNA helicase DDX60-like

1

2

High-throughput

0.437

High

775678

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

775681

TAXB1
Tax1-binding protein 1

1

1

High-throughput

0.437

High

775721

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

775735

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

516822

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.426

High

529223

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

563329

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

567277

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.426

High

775650

SRSF2
Serine/arginine-rich splicing factor 2

1

0

Small-scale

0.426

High

775683

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.426

High

775719

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

775723

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

775632

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

775670

H31T
Histone H3.1t

1

4

High-throughput

0.408

High

775692

GPT11
G patch domain-containing protein 11

2

0

High-throughput

0.316

High

775717

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.305

High

775689

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.298

High

775688

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

157025

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

256543

PRAM2
PRAME family member 2

1

0

Small-scale

0.249

Low

377428

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

450328

ACBP
Acyl-CoA-binding protein

1

0

High-throughput

0.249

Low

590826

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

774183

BASI
Basigin

1

0

High-throughput

0.249

Low

775664

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

775693

CC112
Coiled-coil domain-containing protein 112

1

0

High-throughput

0.249

Low

775697

SSH1
Protein phosphatase Slingshot homolog 1

1

0

High-throughput

0.249

Low

775715

PPR36
Protein phosphatase 1 regulatory subunit 36

1

0

High-throughput

0.249

Low

775725

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.249

Low

133453

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

775690

S35G3
Solute carrier family 35 member G3

1

0

High-throughput

0.232

Low

775711

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low

775714

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025