Protein: PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (PDPr)

Gene: PDPR
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q8NCN5

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0045253 - pyruvate dehydrogenase (lipoamide) phosphatase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1335937

T22D4
TSC22 domain family protein 4

3

2

High-throughput

0.667

High

643520

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

3

0

High-throughput

0.638

High

275327

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

1238402

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

348620

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.618

High

665642

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

1

High-throughput

0.611

High

225207

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.602

High

349689

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

1335931

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

0

High-throughput

0.602

High

1211779

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

0

High-throughput

0.585

High

1335918

RM37
Large ribosomal subunit protein mL37

2

0

High-throughput

0.585

High

279834

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

292375

RA51D
DNA repair protein RAD51 homolog 4

2

0

High-throughput

0.576

High

1335929

TRM1
tRNA

2

0

High-throughput

0.576

High

1335934

DKKL1
Dickkopf-like protein 1

2

1

High-throughput

0.574

High

641810

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.536

High

1113729

CUL3
Cullin-3

1

4

High-throughput

0.536

High

962984

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

1293463

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.513

High

1335911

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.513

High

1335935

PSG8
Pregnancy-specific beta-1-glycoprotein 8

1

2

High-throughput

0.489

High

242313

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

282010

MPPB
Mitochondrial-processing peptidase subunit beta

1

3

High-throughput

0.479

High

287334

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

412271

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

414236

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

471141

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

4

High-throughput

0.479

High

532782

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.479

High

560021

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.479

High

856315

IF2M
Translation initiation factor IF-2, mitochondrial

1

3

High-throughput

0.479

High

882783

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

1033729

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

1062830

QOR
Quinone oxidoreductase

1

1

High-throughput

0.479

High

1083673

MPPA
Mitochondrial-processing peptidase subunit alpha

1

3

High-throughput

0.479

High

1117784

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

1162431

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.479

High

1240308

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

1

High-throughput

0.479

High

1254691

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1272941

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

1310240

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

1328431

S2541
Mitochondrial carrier protein SCaMC-3L

1

3

High-throughput

0.479

High

1335900

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

2

High-throughput

0.479

High

1335901

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

1335902

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1335910

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

1335912

TACO1
Translational activator of cytochrome c oxidase 1

1

1

High-throughput

0.479

High

1335919

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1335920

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

1

High-throughput

0.479

High

1335921

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

1335927

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

1335930

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

1335933

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

66242

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

350927

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

361647

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

519166

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

828857

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841834

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851958

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

1048601

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1090468

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1123352

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1142602

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1149595

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1207076

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1335904

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1335905

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1335913

MTG1
Mitochondrial ribosome-associated GTPase 1

1

0

High-throughput

0.458

High

1335914

TR61B
tRNA

1

0

High-throughput

0.458

High

1335915

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1335916

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.458

High

1335917

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1335922

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1335923

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1335924

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1335925

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1335928

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1335932

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1335936

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

653448

HEMH
Ferrochelatase, mitochondrial

1

3

High-throughput

0.445

High

1100139

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.437

High

1335938

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

1

0

High-throughput

0.426

High

1330811

TSYL6
Testis-specific Y-encoded-like protein 6

2

0

High-throughput

0.328

High

1335903

ARHGQ
Rho guanine nucleotide exchange factor 26

2

0

High-throughput

0.318

High

1335909

RB40C
Ras-related protein Rab-40C

1

0

High-throughput

0.279

Low

1335926

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.249

Low

1155011

ADIPO
Adiponectin

1

0

High-throughput

0.232

Low

1335906

MFSD3
Major facilitator superfamily domain-containing protein 3

1

0

High-throughput

0.232

Low

1335907

F167A
Protein FAM167A

1

0

High-throughput

0.232

Low

1335908

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025