Protein: DNLI1
DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1)

Gene: DNLI1, LIG1
Organism: Homo sapiens
Interactions: 60
UniProt ID: P18858

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003909 - DNA ligase activity
GO:0003910 - DNA ligase (ATP) activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550830

PCNA
Proliferating cell nuclear antigen

3

5

Small-scale

0.834

High

617459

UHRF1
E3 ubiquitin-protein ligase UHRF1

5

9

Small-scale

0.713

High

617458

EHMT2
Histone-lysine N-methyltransferase EHMT2

3

8

Small-scale

0.655

High

617425

DNLI1
DNA ligase 1

1

8

High-throughput

0.618

High

617435

DCAF7
DDB1- and CUL4-associated factor 7

1

2

Small-scale

0.578

High

617437

CBX3
Chromobox protein homolog 3

2

10

Small-scale

0.563

High

617454

RN166
E3 ubiquitin-protein ligase RNF166

2

3

High-throughput

0.558

High

415338

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.541

High

169940

AURKA
Aurora kinase A

1

2

High-throughput

0.536

High

617450

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

4

High-throughput

0.536

High

595922

H12
Histone H1.2

1

8

High-throughput

0.515

High

445121

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

617444

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

436604

KPCB
Protein kinase C beta type

1

1

Small-scale

0.501

High

617464

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

7

Small-scale

0.501

High

346840

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

617430

RGS2
Regulator of G-protein signaling 2

1

0

High-throughput

0.486

High

617434

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.481

High

190810

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

10

High-throughput

0.479

High

240708

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

371123

MYC
Myc proto-oncogene protein

1

11

High-throughput

0.479

High

411326

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

612856

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

617427

CDK2
Cyclin-dependent kinase 2

1

2

Small-scale

0.479

High

617428

APEX1
DNA repair nuclease/redox regulator APEX1

1

2

High-throughput

0.479

High

617429

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.479

High

617431

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

617436

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

617438

TIF1B
Transcription intermediary factor 1-beta

1

11

High-throughput

0.479

High

617439

CUL4A
Cullin-4A

1

7

Small-scale

0.479

High

617440

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.479

High

617441

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

617442

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.479

High

617446

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

617456

THOC1
THO complex subunit 1

1

1

High-throughput

0.479

High

617462

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.479

High

617465

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

617447

UBE3B
Ubiquitin-protein ligase E3B

1

1

High-throughput

0.470

High

253184

RAD1
Cell cycle checkpoint protein RAD1

1

0

Small-scale

0.458

High

261694

HUS1
Checkpoint protein HUS1

1

0

Small-scale

0.458

High

617426

COF1
Cofilin-1

1

0

High-throughput

0.458

High

617448

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

617455

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

617460

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.458

High

407974

TBB4A
Tubulin beta-4A chain

1

2

High-throughput

0.457

High

617432

INPP
Inositol polyphosphate 1-phosphatase

1

0

High-throughput

0.438

High

617445

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

617453

NUDC2
NudC domain-containing protein 2

1

2

High-throughput

0.437

High

617463

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

617433

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.408

High

617449

MIER1
Mesoderm induction early response protein 1

1

2

Small-scale

0.408

High

617451

CDYL2
Chromodomain Y-like protein 2

1

2

Small-scale

0.408

High

617457

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

1

Small-scale

0.408

High

617461

PHF20
PHD finger protein 20

1

5

Small-scale

0.408

High

617466

CDYL
Chromodomain Y-like protein

1

3

Small-scale

0.408

High

617467

CDY1
Testis-specific chromodomain protein Y 1

1

2

Small-scale

0.408

High

229182

B3GT2
Beta-1,3-galactosyltransferase 2

1

1

High-throughput

0.407

High

617443

SPXN5
Sperm protein associated with the nucleus on the X chromosome N5

1

0

High-throughput

0.279

Low

617452

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025