Protein: RNF5
E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)

Gene: RNF5
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q99942

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1282336

UB2E3
Ubiquitin-conjugating enzyme E2 E3

7

20

Small-scale

0.965

High

919838

UB2D2
Ubiquitin-conjugating enzyme E2 D2

7

20

Small-scale

0.962

High

895892

UB2D3
Ubiquitin-conjugating enzyme E2 D3

6

20

Small-scale

0.952

High

1307252

RNF5
E3 ubiquitin-protein ligase RNF5

6

17

Small-scale

0.947

High

896364

UBE2K
Ubiquitin-conjugating enzyme E2 K

5

20

High-throughput

0.931

High

849424

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

High-throughput

0.911

High

1297363

UB2E2
Ubiquitin-conjugating enzyme E2 E2

4

20

High-throughput

0.911

High

1307272

UB2D4
Ubiquitin-conjugating enzyme E2 D4

4

20

High-throughput

0.911

High

1284879

UBE2W
Ubiquitin-conjugating enzyme E2 W

2

20

High-throughput

0.834

High

1307273

UB2J1
Ubiquitin-conjugating enzyme E2 J1

2

20

Small-scale

0.789

High

851879

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.785

High

1292346

RN185
E3 ubiquitin-protein ligase RNF185

4

18

Small-scale

0.701

High

1307262

UBTD1
Ubiquitin domain-containing protein 1

2

3

High-throughput

0.700

High

1033138

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1307261

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1190075

MAVS
Mitochondrial antiviral-signaling protein

4

12

Small-scale

0.694

High

529632

CFTR
Cystic fibrosis transmembrane conductance regulator

4

3

Small-scale

0.687

High

1307256

DERL1
Derlin-1

4

4

Small-scale

0.686

High

792838

EAA3
Excitatory amino acid transporter 3

3

1

High-throughput

0.675

High

1307276

INSI2
Insulin-induced gene 2 protein

3

2

High-throughput

0.675

High

1256034

RHBL4
Rhomboid-related protein 4

3

3

High-throughput

0.665

High

1203571

STING
Stimulator of interferon genes protein

3

3

Small-scale

0.650

High

476274

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

Small-scale

0.647

High

891430

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

Small-scale

0.647

High

896528

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1138910

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

803715

BAG6
Large proline-rich protein BAG6

1

20

Small-scale

0.618

High

1174921

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

4

High-throughput

0.618

High

1307257

TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1

1

4

Small-scale

0.618

High

1239803

CYAC3
Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

3

2

High-throughput

0.616

High

1307258

YIPF2
Protein YIPF2

3

2

High-throughput

0.616

High

847627

BAP31
B-cell receptor-associated protein 31

2

5

Small-scale

0.611

High

982766

PLP2
Proteolipid protein 2

2

1

High-throughput

0.606

High

1221942

PLPP6
Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

2

1

High-throughput

0.606

High

1230218

ORML3
ORM1-like protein 3

2

1

High-throughput

0.606

High

1307255

YIPF4
Protein YIPF4

2

3

High-throughput

0.606

High

1307270

PRAF1
Prenylated Rab acceptor protein 1

2

3

High-throughput

0.606

High

1307274

YIPF1
Protein YIPF1

2

2

High-throughput

0.606

High

823482

PAXI
Paxillin

1

13

Small-scale

0.596

High

1291147

Q96FI0
N-terminal E2 ubiquitin-conjugating enzyme

1

20

High-throughput

0.594

High

396792

S10A8
Protein S100-A8

2

7

Small-scale

0.584

High

1307271

AMFR
E3 ubiquitin-protein ligase AMFR

2

11

Small-scale

0.584

High

1307264

S38A7
Sodium-coupled neutral amino acid transporter 7

2

1

High-throughput

0.583

High

136209

SCD
Stearoyl-CoA desaturase

2

0

High-throughput

0.580

High

515728

CD20
B-lymphocyte antigen CD20

2

0

High-throughput

0.580

High

1065300

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

0

High-throughput

0.580

High

1169569

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.580

High

665424

EPHA3
Ephrin type-A receptor 3

1

5

Small-scale

0.561

High

872697

EPHA4
Ephrin type-A receptor 4

1

7

Small-scale

0.561

High

1157366

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

1

Small-scale

0.561

High

1198663

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

8

Small-scale

0.561

High

1293798

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

2

Small-scale

0.561

High

1264273

BRI3B
BRI3-binding protein

2

1

High-throughput

0.558

High

1307268

JKAMP
JNK1/MAPK8-associated membrane protein

1

0

Small-scale

0.554

High

242280

PRAF2
PRA1 family protein 2

2

2

High-throughput

0.553

High

1287706

F241B
Protein FAM241B

2

1

High-throughput

0.553

High

1294697

SC22A
Vesicle-trafficking protein SEC22a

1

0

High-throughput

0.549

High

1307266

CLN6
Ceroid-lipofuscinosis neuronal protein 6

2

0

Small-scale

0.547

High

782462

P2RY2
P2Y purinoceptor 2

1

6

High-throughput

0.536

High

848462

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

1078141

AAAT
Neutral amino acid transporter B(0)

1

1

Small-scale

0.536

High

1119220

MBRL
Membralin

1

2

High-throughput

0.536

High

1150160

ATLA3
Atlastin-3

1

1

High-throughput

0.536

High

1300300

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

Small-scale

0.536

High

1302910

KCNKG
Potassium channel subfamily K member 16

1

1

High-throughput

0.536

High

1307263

GPR35
G-protein coupled receptor 35

1

6

High-throughput

0.536

High

1307275

SRPRB
Signal recognition particle receptor subunit beta

1

3

High-throughput

0.536

High

72156

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

828131

CY561
Transmembrane ascorbate-dependent reductase CYB561

1

2

High-throughput

0.523

High

1166362

ZDH24
Probable palmitoyltransferase ZDHHC24

1

1

High-throughput

0.515

High

1307269

ORML1
ORM1-like protein 1

1

1

High-throughput

0.515

High

168201

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

0

High-throughput

0.513

High

238907

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.513

High

989644

ACHD
Acetylcholine receptor subunit delta

1

0

High-throughput

0.513

High

1239852

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.513

High

1283253

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1138854

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.493

High

207100

XRCC3
DNA repair protein XRCC3

1

3

High-throughput

0.489

High

330713

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.489

High

1236335

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

1

High-throughput

0.489

High

1255499

ST7L
Suppressor of tumorigenicity 7 protein-like

1

2

High-throughput

0.489

High

1305076

DNJC7
DnaJ homolog subfamily C member 7

1

7

High-throughput

0.489

High

1307253

TBA1C
Tubulin alpha-1C chain

1

11

High-throughput

0.489

High

599718

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

High-throughput

0.481

High

793756

GLP1R
Glucagon-like peptide 1 receptor

1

1

Small-scale

0.481

High

266233

ERLN1
Erlin-1

1

9

High-throughput

0.479

High

299975

ERLN2
Erlin-2

1

10

Small-scale

0.479

High

321929

RIGI
Antiviral innate immune response receptor RIG-I

1

15

Small-scale

0.479

High

416501

S10A9
Protein S100-A9

1

7

High-throughput

0.479

High

429114

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.479

High

429930

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

874681

BI1
Bax inhibitor 1

1

3

High-throughput

0.479

High

883864

TMM33
Transmembrane protein 33

1

1

High-throughput

0.479

High

976808

TAP2
Antigen peptide transporter 2

1

3

Small-scale

0.479

High

982428

1433F
14-3-3 protein eta

1

12

High-throughput

0.479

High

1016018

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

6

Small-scale

0.479

High

1165894

LMBRL
Protein LMBR1L

1

2

High-throughput

0.479

High

1204823

GOLI
E3 ubiquitin-protein ligase RNF130

1

6

High-throughput

0.479

High

1240743

RN149
E3 ubiquitin-protein ligase RNF149

1

7

High-throughput

0.479

High

1259705

RN139
E3 ubiquitin-protein ligase RNF139

1

7

High-throughput

0.479

High

1307259

DERL2
Derlin-2

1

4

Small-scale

0.479

High

1307267

DJB12
DnaJ homolog subfamily B member 12

1

6

Small-scale

0.479

High

1307277

PD2R2
Prostaglandin D2 receptor 2

1

7

High-throughput

0.479

High

431270

CATB
Cathepsin B

1

3

High-throughput

0.470

High

1287351

OPTN
Optineurin

1

17

High-throughput

0.470

High

1307278

FHOD1
FH1/FH2 domain-containing protein 1

1

2

Small-scale

0.464

High

342578

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

725862

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.458

High

1034803

TMED1
Transmembrane emp24 domain-containing protein 1

1

0

High-throughput

0.458

High

1267999

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.458

High

1307254

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

484891

ZTRF1
Zinc finger TRAF-type-containing protein 1

1

6

High-throughput

0.445

High

1241590

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.445

High

197386

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.437

High

637287

CATS
Cathepsin S

1

2

High-throughput

0.437

High

779989

CCNF
Cyclin-F

1

5

High-throughput

0.437

High

822505

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

3

High-throughput

0.437

High

997874

RBBP4
Histone-binding protein RBBP4

1

8

Small-scale

0.437

High

1085656

HIF1A
Hypoxia-inducible factor 1-alpha

1

8

Small-scale

0.437

High

1307260

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

354982

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

0

High-throughput

0.426

High

327024

ABHGA
Phosphatidylserine lipase ABHD16A

4

0

Small-scale

0.367

High

49363

T120B
Transmembrane protein 120B

2

0

High-throughput

0.316

High

307728

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

1292580

RUSF1
RUS family member 1

2

0

High-throughput

0.316

High

1307265

TM242
Transmembrane protein 242

1

0

High-throughput

0.299

High

1191370

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.279

Low

1192433

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.268

Low

304449

REC8
Meiotic recombination protein REC8 homolog

1

0

Small-scale

0.249

Low

311282

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.249

Low

389595

TYSY
Thymidylate synthase

1

0

High-throughput

0.249

Low

523481

PEPD
Xaa-Pro dipeptidase

1

0

High-throughput

0.249

Low

914566

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024