Protein: SHLD2
Shieldin complex subunit 2 (Protein FAM35A) (RINN1-REV7-interacting novel NHEJ regulator 2) (Shield complex subunit 2)

Gene: SHLD2
Organism: Homo sapiens
Interactions: 50
UniProt ID: Q86V20

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0002208 - somatic diversification of immunoglobulins involved in immune response
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1289804

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

6

0

Small-scale

0.705

High

1289794

SHLD1
Shieldin complex subunit 1

3

1

Small-scale

0.674

High

1289792

SHLD2
Shieldin complex subunit 2

2

0

Small-scale

0.559

High

946824

H2B1D
Histone H2B type 1-D

1

0

High-throughput

0.493

High

1088897

TP53B
TP53-binding protein 1

1

0

Small-scale

0.479

High

132492

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.479

High

854881

RECQ1
ATP-dependent DNA helicase Q1

1

2

High-throughput

0.479

High

1113571

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1115279

CUL4B
Cullin-4B

1

2

High-throughput

0.479

High

1122933

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

2

High-throughput

0.479

High

1289793

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

1

High-throughput

0.479

High

1289797

CUL5
Cullin-5

1

2

High-throughput

0.479

High

160189

CHD2
Chromodomain-helicase-DNA-binding protein 2

1

0

High-throughput

0.458

High

166537

BACH1
Transcription regulator protein BACH1

1

0

High-throughput

0.458

High

281225

CDC45
Cell division control protein 45 homolog

1

0

High-throughput

0.458

High

337362

PARN
Poly(A)-specific ribonuclease PARN

1

0

High-throughput

0.458

High

414128

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

485239

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

617448

DNLI1
DNA ligase 1

1

0

High-throughput

0.458

High

832916

CETN2
Centrin-2

1

0

High-throughput

0.458

High

904323

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

1025276

CDK3
Cyclin-dependent kinase 3

1

0

High-throughput

0.458

High

1118844

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.458

High

1125145

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

0

High-throughput

0.458

High

1125766

FA50A
Protein FAM50A

1

0

Small-scale

0.458

High

1129335

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

0

High-throughput

0.458

High

1157793

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.458

High

1272235

MCM10
Protein MCM10 homolog

1

0

High-throughput

0.458

High

1272475

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.458

High

1289795

TF2H4
General transcription factor IIH subunit 4

1

0

High-throughput

0.458

High

1289796

XPF
DNA repair endonuclease XPF

1

0

High-throughput

0.458

High

1289798

TONSL
Tonsoku-like protein

1

0

High-throughput

0.458

High

1289800

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.458

High

1289801

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1289802

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.458

High

1289803

PARP2
Poly [ADP-ribose] polymerase 2

1

0

High-throughput

0.458

High

558242

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.445

High

559405

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.445

High

926373

BLM
RecQ-like DNA helicase BLM

1

2

Small-scale

0.445

High

821434

TCPZ
T-complex protein 1 subunit zeta

1

1

High-throughput

0.437

High

1106434

TOP3A
DNA topoisomerase 3-alpha

1

0

Small-scale

0.426

High

1217146

RIF1
Telomere-associated protein RIF1

1

0

Small-scale

0.426

High

1253261

SHLD3
Shieldin complex subunit 3

1

0

High-throughput

0.426

High

1030796

DEF5
Defensin alpha 5

2

0

High-throughput

0.328

High

1135490

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

81720

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

0

Small-scale

0.249

Low

868204

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.249

Low

926098

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.249

Low

1289799

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025