Protein: CSTN1
Calsyntenin-1 (Alcadein-alpha) (Alc-alpha) (Alzheimer-related cadherin-like protein) (Non-classical cadherin XB31alpha) [Cleaved into: Soluble Alc-alpha (SAlc-alpha); CTF1-alpha (C-terminal fragment 1-alpha)]

Gene: CSTN1, CLSTN1
Organism: Homo sapiens
Interactions: 139
UniProt ID: O94985

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001540 - amyloid-beta binding
GO:0001558 - regulation of cell growth
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

324063

PCDA4
Protocadherin alpha-4

2

20

High-throughput

0.811

High

324031

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

4

13

Small-scale

0.692

High

64335

CDHR4
Cadherin-related family member 4

1

20

High-throughput

0.691

High

323959

PRG2
Bone marrow proteoglycan

1

5

High-throughput

0.691

High

324006

CDHR3
Cadherin-related family member 3

1

20

High-throughput

0.691

High

324015

PCD20
Protocadherin-20

1

20

High-throughput

0.691

High

324045

CSTN2
Calsyntenin-2

1

20

High-throughput

0.691

High

323949

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

3

15

High-throughput

0.662

High

323983

DEF5
Defensin alpha 5

3

2

High-throughput

0.662

High

323986

KLC1
Kinesin light chain 1

3

10

Small-scale

0.650

High

323956

A4
Amyloid-beta precursor protein

3

5

Small-scale

0.650

High

323957

CD48
CD48 antigen

1

19

High-throughput

0.618

High

324059

BTNL2
Butyrophilin-like protein 2

1

8

High-throughput

0.618

High

324042

CHST8
Carbohydrate sulfotransferase 8

2

1

High-throughput

0.611

High

323973

EAA1
Excitatory amino acid transporter 1

2

2

High-throughput

0.601

High

324009

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

2

2

High-throughput

0.601

High

323969

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

16

Small-scale

0.561

High

323982

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

High-throughput

0.561

High

324052

GINM1
Glycoprotein integral membrane protein 1

2

2

High-throughput

0.558

High

324050

CAH10
Carbonic anhydrase-related protein 10

2

4

High-throughput

0.549

High

154785

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

11

High-throughput

0.536

High

191430

SIA8E
Alpha-2,8-sialyltransferase 8E

1

8

High-throughput

0.536

High

239266

GMFG
Glia maturation factor gamma

1

3

High-throughput

0.536

High

253423

CST8
Cystatin-8

1

4

High-throughput

0.536

High

323946

LY86
Lymphocyte antigen 86

1

5

High-throughput

0.536

High

323948

BY55
CD160 antigen

1

7

High-throughput

0.536

High

323951

C1QB
Complement C1q subcomponent subunit B

1

10

High-throughput

0.536

High

323955

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

1

High-throughput

0.536

High

323963

COT2
COUP transcription factor 2

1

4

High-throughput

0.536

High

323966

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.536

High

323974

DNSL1
Deoxyribonuclease-1-like 1

1

1

High-throughput

0.536

High

323976

TTC3
E3 ubiquitin-protein ligase TTC3

1

4

High-throughput

0.536

High

323979

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.536

High

323980

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.536

High

323988

SLAF1
Signaling lymphocytic activation molecule

1

20

High-throughput

0.536

High

323992

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

High-throughput

0.536

High

323994

OZF
Zinc finger protein OZF

1

1

High-throughput

0.536

High

323999

EGFLA
Pikachurin

1

20

High-throughput

0.536

High

324004

LYZL1
Lysozyme-like protein 1

1

1

High-throughput

0.536

High

324008

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

6

High-throughput

0.536

High

324017

TM87A
Transmembrane protein 87A

1

2

High-throughput

0.536

High

324020

OIT3
Oncoprotein-induced transcript 3 protein

1

20

High-throughput

0.536

High

324022

GGH
Gamma-glutamyl hydrolase

1

1

High-throughput

0.536

High

324038

CNTP3
Contactin-associated protein-like 3

1

20

High-throughput

0.536

High

324040

KLC2
Kinesin light chain 2

1

8

High-throughput

0.536

High

324041

CSTL1
Cystatin-like 1

1

4

High-throughput

0.536

High

324049

JPH1
Junctophilin-1

1

1

High-throughput

0.536

High

324051

KLC4
Kinesin light chain 4

1

9

High-throughput

0.536

High

324055

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

1

1

High-throughput

0.536

High

324066

LIPG
Endothelial lipase

1

1

High-throughput

0.536

High

105002

APRIO
Alternative prion protein

2

5

High-throughput

0.533

High

323987

RBBP4
Histone-binding protein RBBP4

1

5

High-throughput

0.515

High

323995

LPAL2
Putative apolipoprotein(a)-like protein 2

1

2

High-throughput

0.515

High

324060

CCNL1
Cyclin-L1

1

2

High-throughput

0.515

High

324068

NUMBL
Numb-like protein

1

4

High-throughput

0.515

High

323952

TRGV3
T cell receptor gamma variable 3

1

2

High-throughput

0.514

High

323954

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

323964

PSA4
Proteasome subunit alpha type-4

1

0

High-throughput

0.513

High

323984

CEBPZ
CCAAT/enhancer-binding protein zeta

1

0

High-throughput

0.513

High

323989

PLD1
Phospholipase D1

1

0

High-throughput

0.513

High

323996

MBRL
Membralin

1

0

High-throughput

0.513

High

324019

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

324032

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

324046

CDCP1
CUB domain-containing protein 1

1

0

High-throughput

0.513

High

324047

CN093
Uncharacterized protein C14orf93

1

0

High-throughput

0.513

High

324056

ZN629
Zinc finger protein 629

1

0

High-throughput

0.513

High

324057

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.513

High

324013

RNF10
E3 ubiquitin-protein ligase RNF10

1

0

High-throughput

0.511

High

245658

GANP
Germinal-center associated nuclear protein

1

1

Small-scale

0.508

High

323991

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

10

Small-scale

0.508

High

323993

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

Small-scale

0.508

High

324003

LYPD5
Ly6/PLAUR domain-containing protein 5

1

0

High-throughput

0.493

High

261902

PP1RB
E3 ubiquitin-protein ligase PPP1R11

1

0

High-throughput

0.493

High

323990

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.493

High

140695

NOP56
Nucleolar protein 56

1

1

High-throughput

0.489

High

291039

UTP20
Small subunit processome component 20 homolog

1

1

High-throughput

0.489

High

323945

ECEL1
Endothelin-converting enzyme-like 1

1

1

High-throughput

0.489

High

323968

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.489

High

323972

I12R1
Interleukin-12 receptor subunit beta-1

1

20

High-throughput

0.489

High

323978

RL23
Large ribosomal subunit protein uL14

1

20

High-throughput

0.489

High

323998

TMTC4
Protein O-mannosyl-transferase TMTC4

1

13

High-throughput

0.489

High

324001

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.489

High

324002

POTEE
POTE ankyrin domain family member E

1

3

High-throughput

0.489

High

324024

P2RX5
P2X purinoceptor 5

1

2

High-throughput

0.489

High

324025

T106A
Transmembrane protein 106A

1

3

High-throughput

0.489

High

324027

ASIC4
Acid-sensing ion channel 4

1

2

High-throughput

0.489

High

324030

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

1

High-throughput

0.489

High

324035

TMPSD
Transmembrane protease serine 13

1

11

High-throughput

0.489

High

324037

ADA33
Disintegrin and metalloproteinase domain-containing protein 33

1

7

High-throughput

0.489

High

324039

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.489

High

324044

KLK15
Kallikrein-15

1

20

High-throughput

0.489

High

324048

SDF2L
Stromal cell-derived factor 2-like protein 1

1

9

High-throughput

0.489

High

324054

P2RX2
P2X purinoceptor 2

1

2

High-throughput

0.489

High

324061

KDIS
Kinase D-interacting substrate of 220 kDa

1

4

High-throughput

0.489

High

324067

BACE2
Beta-secretase 2

1

3

High-throughput

0.489

High

126940

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

Small-scale

0.479

High

192413

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.479

High

323970

BASI
Basigin

1

14

High-throughput

0.479

High

323971

TACT
T-cell surface protein tactile

1

1

High-throughput

0.479

High

323975

PSN1
Presenilin-1

1

3

Small-scale

0.479

High

323981

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

5

Small-scale

0.479

High

324005

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

324026

SPDLY
Protein Spindly

1

3

High-throughput

0.479

High

324058

XPO7
Exportin-7

1

1

High-throughput

0.479

High

324065

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.479

High

324014

KCD17
BTB/POZ domain-containing protein KCTD17

1

2

High-throughput

0.470

High

324043

SLK
STE20-like serine/threonine-protein kinase

1

12

Small-scale

0.464

High

324053

BAHC1
BAH and coiled-coil domain-containing protein 1

1

1

Small-scale

0.464

High

323960

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

323977

H4
Histone H4

1

0

Small-scale

0.458

High

323985

PAX8
Paired box protein Pax-8

1

0

High-throughput

0.458

High

324021

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.457

High

253137

MOT2
Monocarboxylate transporter 2

1

4

High-throughput

0.445

High

323950

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.445

High

323953

PRIO
Major prion protein

1

1

High-throughput

0.445

High

323961

S1PR1
Sphingosine 1-phosphate receptor 1

1

7

High-throughput

0.445

High

323962

SYT1
Synaptotagmin-1

1

5

High-throughput

0.445

High

323967

SSR2
Somatostatin receptor type 2

1

3

High-throughput

0.445

High

324011

YAF2
YY1-associated factor 2

1

3

High-throughput

0.445

High

324012

LYPD1
Ly6/PLAUR domain-containing protein 1

1

1

High-throughput

0.445

High

324023

EDA
Ectodysplasin-A

1

3

High-throughput

0.445

High

324034

SYT11
Synaptotagmin-11

1

5

High-throughput

0.445

High

324062

FZD10
Frizzled-10

1

3

High-throughput

0.445

High

217646

TGON2
Trans-Golgi network integral membrane protein 2

1

17

High-throughput

0.437

High

222236

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

324064

INSL6
Insulin-like peptide INSL6

1

0

High-throughput

0.426

High

323965

5HT2C
5-hydroxytryptamine receptor 2C

1

3

High-throughput

0.407

High

324007

NIPA1
Magnesium transporter NIPA1

1

5

High-throughput

0.407

High

324010

SL9A9
Sodium/hydrogen exchanger 9

1

1

High-throughput

0.407

High

324016

SYT2
Synaptotagmin-2

1

5

High-throughput

0.407

High

324018

MFSD9
Major facilitator superfamily domain-containing protein 9

1

4

High-throughput

0.407

High

324029

MF14A
Hippocampus abundant transcript 1 protein

1

4

High-throughput

0.407

High

324036

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

324000

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

323947

SG1D1
Secretoglobin family 1D member 1

3

0

High-throughput

0.345

High

324033

TM2D3
TM2 domain-containing protein 3

2

0

High-throughput

0.318

High

324028

EXOC2
Exocyst complex component 2

1

0

High-throughput

0.279

Low

323958

CLCA
Clathrin light chain A

1

0

High-throughput

0.268

Low

323997

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025