Protein: HPHL1
Ferroxidase HEPHL1 (EC 1.16.3.1) (Hephaestin-like protein 1)

Gene: HPHL1, HEPHL1
Organism: Homo sapiens
Interactions: 73
UniProt ID: Q6MZM0

Gene Ontology (top 5):
GO:0004322 - ferroxidase activity
GO:0005507 - copper ion binding
GO:0005886 - plasma membrane
GO:0006825 - copper ion transport
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1236020

LACC1
Purine nucleoside phosphorylase LACC1

3

0

High-throughput

0.638

High

1236039

O51E2
Olfactory receptor 51E2

3

0

High-throughput

0.638

High

1236018

GPBP1
Vasculin

2

0

High-throughput

0.602

High

1236025

IL31R
Interleukin-31 receptor subunit alpha

2

0

High-throughput

0.602

High

1236028

FAN
Protein FAN

2

1

High-throughput

0.574

High

1236032

RM38
Large ribosomal subunit protein mL38

2

1

High-throughput

0.574

High

733374

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.536

High

943071

STX17
Syntaxin-17

1

1

High-throughput

0.536

High

1102947

ITAD
Integrin alpha-D

1

1

High-throughput

0.536

High

301808

ANXA9
Annexin A9

1

0

High-throughput

0.513

High

762408

BTC
Probetacellulin [Cleaved into: Betacellulin

1

0

High-throughput

0.513

High

1235223

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

1

0

High-throughput

0.513

High

1236015

NPSR1
Neuropeptide S receptor

1

0

High-throughput

0.513

High

1236033

DTBP1
Dysbindin

1

0

High-throughput

0.513

High

1236037

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

0

High-throughput

0.513

High

1236040

SRMS
Tyrosine-protein kinase Srms

1

0

High-throughput

0.513

High

1236042

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

0

High-throughput

0.513

High

1116959

CD166
CD166 antigen

1

0

High-throughput

0.493

High

284165

SRS10
Serine/arginine-rich splicing factor 10

1

1

High-throughput

0.489

High

1023806

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

1

High-throughput

0.489

High

1236031

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

1236036

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

1236043

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.489

High

1236051

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.489

High

1236054

SSUH2
Protein SSUH2 homolog

1

1

High-throughput

0.489

High

961533

VA0D1
V-type proton ATPase subunit d 1

1

0

High-throughput

0.458

High

1236023

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.426

High

1200939

SGO2
Shugoshin 2

3

0

High-throughput

0.347

High

1211595

TEX35
Testis-expressed protein 35

3

0

High-throughput

0.347

High

1235443

IFIX
Pyrin and HIN domain-containing protein 1

3

0

High-throughput

0.347

High

1236019

DOPP1
Dolichyldiphosphatase 1

3

0

High-throughput

0.347

High

1236029

TFG
Protein TFG

3

0

High-throughput

0.347

High

1236030

PMM1
Phosphomannomutase 1

3

0

High-throughput

0.347

High

1236034

MTNB
Methylthioribulose-1-phosphate dehydratase

3

0

High-throughput

0.347

High

1236047

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

3

0

High-throughput

0.347

High

418201

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

2

0

High-throughput

0.328

High

1036574

SEMG2
Semenogelin-2

2

0

High-throughput

0.328

High

1236027

CPLX3
Complexin-3

2

0

High-throughput

0.328

High

1236035

SETB2
Histone-lysine N-methyltransferase SETDB2

2

0

High-throughput

0.328

High

1236041

ZMAT4
Zinc finger matrin-type protein 4

2

0

High-throughput

0.328

High

1236045

TBC14
TBC1 domain family member 14

2

0

High-throughput

0.328

High

1236050

FBXL4
F-box/LRR-repeat protein 4

2

0

High-throughput

0.328

High

1236052

OAZ3
Ornithine decarboxylase antizyme 3

2

0

High-throughput

0.328

High

1236055

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.328

High

1093468

COASY
Bifunctional coenzyme A synthase

2

0

High-throughput

0.318

High

1155348

RB11B
Ras-related protein Rab-11B

2

0

High-throughput

0.318

High

49398

DHR12
Dehydrogenase/reductase SDR family member 12

1

0

High-throughput

0.279

Low

133863

FOXN3
Forkhead box protein N3

1

0

High-throughput

0.279

Low

325324

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

326720

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.279

Low

370699

FOS
Protein c-Fos

1

0

High-throughput

0.279

Low

469500

SYPH
Synaptophysin

1

0

High-throughput

0.279

Low

755489

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.279

Low

866726

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.279

Low

876343

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

1087057

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.279

Low

1203364

YIF1B
Protein YIF1B

1

0

High-throughput

0.279

Low

1206191

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1212712

TMTC4
Protein O-mannosyl-transferase TMTC4

1

0

High-throughput

0.279

Low

1236016

HEPN1
Putative cancer susceptibility gene HEPN1 protein

1

0

High-throughput

0.279

Low

1236017

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1236021

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

1236022

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

1236024

BHE23
Class E basic helix-loop-helix protein 23

1

0

High-throughput

0.279

Low

1236026

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1236038

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.279

Low

1236044

KLH11
Kelch-like protein 11

1

0

High-throughput

0.279

Low

1236046

PEMT
Phosphatidylethanolamine N-methyltransferase

1

0

High-throughput

0.279

Low

1236048

DPOG2
DNA polymerase subunit gamma-2

1

0

High-throughput

0.279

Low

1236049

FBX3
F-box only protein 3

1

0

High-throughput

0.279

Low

1236053

LRCH1
Leucine-rich repeat and calponin homology domain-containing protein 1

1

0

High-throughput

0.279

Low

319839

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

965025

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025