Protein: TLK2
Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (HsHPK) (PKU-alpha) (Tousled-like kinase 2)

Gene: TLK2
Organism: Homo sapiens
Interactions: 145
UniProt ID: Q86UE8

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1199548

TLK1
Serine/threonine-protein kinase tousled-like 1

7

17

Small-scale

0.963

High

924053

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

8

High-throughput

0.811

High

1199497

TLK2
Serine/threonine-protein kinase tousled-like 2

2

16

High-throughput

0.783

High

1199551

ASF1A
Histone chaperone ASF1A

8

6

Small-scale

0.755

High

227931

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

1199538

ASF1B
Histone chaperone ASF1B

7

6

Small-scale

0.751

High

928362

DYL1
Dynein light chain 1, cytoplasmic

6

6

Small-scale

0.737

High

160646

AURKA
Aurora kinase A

1

18

Small-scale

0.724

High

1199515

DYL2
Dynein light chain 2, cytoplasmic

4

6

High-throughput

0.699

High

647619

MK03
Mitogen-activated protein kinase 3

1

18

High-throughput

0.691

High

1073443

KS6A1
Ribosomal protein S6 kinase alpha-1

1

17

High-throughput

0.691

High

272942

RFPL3
Ret finger protein-like 3

3

6

High-throughput

0.667

High

1199501

EID3
EP300-interacting inhibitor of differentiation 3

3

1

High-throughput

0.667

High

1199550

LHX6
LIM/homeobox protein Lhx6

3

3

High-throughput

0.667

High

1199554

CABIN
Calcineurin-binding protein cabin-1

3

3

High-throughput

0.667

High

385096

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.618

High

1199549

SCML1
Sex comb on midleg-like protein 1

1

1

High-throughput

0.618

High

867880

HIRA
Protein HIRA

2

6

High-throughput

0.611

High

641467

PAX6
Paired box protein Pax-6

2

7

High-throughput

0.606

High

971667

PAX5
Paired box protein Pax-5

2

6

High-throughput

0.606

High

1199518

GMCL1
Germ cell-less protein-like 1

2

6

High-throughput

0.606

High

1071050

IRF4
Interferon regulatory factor 4

1

3

High-throughput

0.586

High

1199510

IRF7
Interferon regulatory factor 7

1

3

High-throughput

0.586

High

1199535

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

128223

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

10

High-throughput

0.575

High

161397

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

9

High-throughput

0.575

High

1101658

AAK1
AP2-associated protein kinase 1

1

19

High-throughput

0.575

High

1199513

DOC10
Dedicator of cytokinesis protein 10

1

6

High-throughput

0.575

High

1199517

GWL
Serine/threonine-protein kinase greatwall

1

18

High-throughput

0.575

High

1199521

STAC3
SH3 and cysteine-rich domain-containing protein 3

1

9

High-throughput

0.575

High

1199539

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

7

High-throughput

0.575

High

1139291

SPAT1
Spermatogenesis-associated protein 1

2

1

High-throughput

0.574

High

1199505

CEP70
Centrosomal protein of 70 kDa

2

1

High-throughput

0.553

High

1199522

FRMD6
FERM domain-containing protein 6

2

11

High-throughput

0.553

High

1199502

RHG24
Rho GTPase-activating protein 24

1

8

High-throughput

0.553

High

1199540

CALL5
Calmodulin-like protein 5

1

14

High-throughput

0.553

High

122211

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

2

High-throughput

0.536

High

517343

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.536

High

627295

MCM3
DNA replication licensing factor MCM3

1

8

High-throughput

0.536

High

727162

DDIT3
DNA damage-inducible transcript 3 protein

1

1

High-throughput

0.536

High

1199519

ABHEB
Putative protein-lysine deacylase ABHD14B

1

1

High-throughput

0.536

High

1199537

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

1

4

High-throughput

0.536

High

1183279

Q7KZS0
SUMO-conjugating enzyme UBC9

1

8

High-throughput

0.515

High

2142

KVD13
Immunoglobulin kappa variable 1D-13

1

1

High-throughput

0.514

High

259648

LIPA2
Liprin-alpha-2

1

11

High-throughput

0.514

High

353163

KVD33
Immunoglobulin kappa variable 1D-33

1

1

High-throughput

0.514

High

1018300

CNTN1
Contactin-1

1

1

High-throughput

0.514

High

1020282

ELAV2
ELAV-like protein 2

1

10

High-throughput

0.514

High

426683

H10
Histone H1.0

1

0

High-throughput

0.513

High

1133070

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.513

High

1149960

REP15
Rab15 effector protein

1

0

High-throughput

0.513

High

1199506

SMRC2
SWI/SNF complex subunit SMARCC2

1

4

High-throughput

0.500

High

533608

TNNT1
Troponin T, slow skeletal muscle

1

1

High-throughput

0.489

High

1199516

CHMP6
Charged multivesicular body protein 6

1

4

High-throughput

0.489

High

930281

UBC9
SUMO-conjugating enzyme UBC9

1

8

High-throughput

0.481

High

262497

TULP3
Tubby-related protein 3

1

1

High-throughput

0.479

High

325257

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

2

High-throughput

0.479

High

345108

CYTA
Cystatin-A

1

2

High-throughput

0.479

High

347204

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

553082

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

651588

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

668797

PML
Protein PML

1

9

High-throughput

0.479

High

825846

NASP
Nuclear autoantigenic sperm protein

1

1

High-throughput

0.479

High

831467

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

832560

MCM2
DNA replication licensing factor MCM2

1

7

High-throughput

0.479

High

934931

H31
Histone H3.1

1

13

High-throughput

0.479

High

1000195

IFFO1
Non-homologous end joining factor IFFO1

1

10

High-throughput

0.479

High

1027094

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1035250

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

8

High-throughput

0.479

High

1083297

RBBP7
Histone-binding protein RBBP7

1

7

High-throughput

0.479

High

1137520

RIF1
Telomere-associated protein RIF1

1

5

High-throughput

0.479

High

1172636

UBN2
Ubinuclein-2

1

2

High-throughput

0.479

High

1188502

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

6

High-throughput

0.479

High

1199500

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1199507

ESR2
Estrogen receptor beta

1

15

High-throughput

0.479

High

1199514

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

9

High-throughput

0.479

High

1199534

S10AE
Protein S100-A14

1

10

High-throughput

0.479

High

1199536

UBN1
Ubinuclein-1

1

1

High-throughput

0.479

High

158820

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

964935

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

1199498

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

1199528

CDAC1
Cytidine and dCMP deaminase domain-containing protein 1

1

0

High-throughput

0.458

High

1199541

GSKIP
GSK3B-interacting protein

1

0

High-throughput

0.458

High

1199552

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.458

High

229872

KIF5C
Kinesin heavy chain isoform 5C

1

4

High-throughput

0.445

High

398268

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

5

High-throughput

0.445

High

398369

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.445

High

531393

K1C10
Keratin, type I cytoskeletal 10

1

12

High-throughput

0.445

High

531600

K2C5
Keratin, type II cytoskeletal 5

1

2

High-throughput

0.445

High

724105

K1C9
Keratin, type I cytoskeletal 9

1

13

High-throughput

0.445

High

739180

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.445

High

789870

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.445

High

793007

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

10

High-throughput

0.445

High

969497

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.445

High

1049590

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

14

High-throughput

0.445

High

1139205

DAB2P
Disabled homolog 2-interacting protein

1

11

High-throughput

0.445

High

1190602

KI21A
Kinesin-like protein KIF21A

1

2

High-throughput

0.445

High

1199524

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

7

High-throughput

0.445

High

1199527

BTBDA
BTB/POZ domain-containing protein 10

1

5

High-throughput

0.445

High

1199529

UCK2
Uridine-cytidine kinase 2

1

1

High-throughput

0.445

High

1199531

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.445

High

1199532

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.445

High

1199533

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

Small-scale

0.445

High

1199542

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

2

Small-scale

0.445

High

1199525

FEZ1
Fasciculation and elongation protein zeta-1

1

1

Small-scale

0.439

High

1199546

FEZ2
Fasciculation and elongation protein zeta-2

1

1

Small-scale

0.439

High

322824

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.437

High

882404

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.437

High

1121921

COBL1
Cordon-bleu protein-like 1

1

4

High-throughput

0.437

High

1199499

AMOL1
Angiomotin-like protein 1

1

14

High-throughput

0.437

High

1199547

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

2

High-throughput

0.437

High

452825

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

1199511

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.426

High

1199512

UPP
Uracil phosphoribosyltransferase homolog

1

0

High-throughput

0.426

High

1199543

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

0

High-throughput

0.426

High

1199544

COE1
Transcription factor COE1

1

0

High-throughput

0.426

High

155390

NRP1
Neuropilin-1

1

1

High-throughput

0.407

High

488278

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.407

High

489772

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.407

High

809862

GLYG
Glycogenin-1

1

1

High-throughput

0.407

High

942469

CNTP1
Contactin-associated protein 1

1

2

High-throughput

0.407

High

992358

KLC1
Kinesin light chain 1

1

2

High-throughput

0.407

High

1040935

MTMR3
Myotubularin-related protein 3

1

6

High-throughput

0.407

High

1136751

MTCL3
Microtubule cross-linking factor 3

1

19

High-throughput

0.407

High

1166629

ISLR2
Immunoglobulin superfamily containing leucine-rich repeat protein 2

1

3

High-throughput

0.407

High

1199503

NLGN1
Neuroligin-1

1

3

High-throughput

0.407

High

1199504

RN214
RING finger protein 214

1

5

High-throughput

0.407

High

1199508

DLG3
Disks large homolog 3

1

6

High-throughput

0.407

High

1199520

ZFR
Zinc finger RNA-binding protein

1

1

High-throughput

0.407

High

1199523

LRFN5
Leucine-rich repeat and fibronectin type-III domain-containing protein 5

1

4

High-throughput

0.407

High

1199526

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.407

High

1199530

PDGFD
Platelet-derived growth factor D

1

3

High-throughput

0.407

High

1199553

SHLB1
Endophilin-B1

1

2

High-throughput

0.407

High

1199545

IL36A
Interleukin-36 alpha

2

0

High-throughput

0.328

High

795547

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.279

Low

828824

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.279

Low

847530

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.279

Low

608871

SPR1B
Cornifin-B

1

0

High-throughput

0.249

Low

533697

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.232

Low

1067873

PA1B3
Platelet-activating factor acetylhydrolase IB subunit alpha1

1

0

High-throughput

0.232

Low

1129974

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.232

Low

1170391

PPR3F
Protein phosphatase 1 regulatory subunit 3F

1

0

High-throughput

0.232

Low

1191111

SPT19
Spermatogenesis-associated protein 19, mitochondrial

1

0

High-throughput

0.232

Low

1199509

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024