Protein: MED24
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)

Gene: MED24
Organism: Homo sapiens
Interactions: 118
UniProt ID: O75448

Gene Ontology (top 5):
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016592 - mediator complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

282432

MED16
Mediator of RNA polymerase II transcription subunit 16

3

1

Small-scale

0.847

High

282431

MED23
Mediator of RNA polymerase II transcription subunit 23

2

1

High-throughput

0.820

High

282364

CDK8
Cyclin-dependent kinase 8

15

3

Small-scale

0.762

High

282414

MED10
Mediator of RNA polymerase II transcription subunit 10

8

1

Small-scale

0.749

High

282411

MED15
Mediator of RNA polymerase II transcription subunit 15

2

0

High-throughput

0.748

High

48881

MED19
Mediator of RNA polymerase II transcription subunit 19

7

1

Small-scale

0.747

High

282383

MED1
Mediator of RNA polymerase II transcription subunit 1

8

2

Small-scale

0.747

High

282416

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.733

High

282421

MED4
Mediator of RNA polymerase II transcription subunit 4

5

1

High-throughput

0.718

High

282415

MED18
Mediator of RNA polymerase II transcription subunit 18

5

1

High-throughput

0.718

High

282407

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.716

High

239509

MED14
Mediator of RNA polymerase II transcription subunit 14

5

1

Small-scale

0.714

High

282354

CCNC
Cyclin-C

5

1

High-throughput

0.706

High

219461

MED7
Mediator of RNA polymerase II transcription subunit 7

4

1

High-throughput

0.699

High

282425

MED29
Mediator of RNA polymerase II transcription subunit 29

4

1

High-throughput

0.699

High

282406

MED12
Mediator of RNA polymerase II transcription subunit 12

4

2

High-throughput

0.694

High

282396

MED25
Mediator of RNA polymerase II transcription subunit 25

4

1

Small-scale

0.691

High

282423

MED17
Mediator of RNA polymerase II transcription subunit 17

4

1

High-throughput

0.691

High

282375

MED21
Mediator of RNA polymerase II transcription subunit 21

5

0

High-throughput

0.690

High

282424

MED9
Mediator of RNA polymerase II transcription subunit 9

5

0

Small-scale

0.686

High

282417

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.684

High

282420

MED20
Mediator of RNA polymerase II transcription subunit 20

4

0

High-throughput

0.670

High

282333

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

High-throughput

0.667

High

282390

MED27
Mediator of RNA polymerase II transcription subunit 27

3

1

High-throughput

0.667

High

282408

MED8
Mediator of RNA polymerase II transcription subunit 8

3

1

High-throughput

0.667

High

282409

MED30
Mediator of RNA polymerase II transcription subunit 30

3

1

Small-scale

0.667

High

282427

MED11
Mediator of RNA polymerase II transcription subunit 11

3

1

High-throughput

0.667

High

282433

MED31
Mediator of RNA polymerase II transcription subunit 31

3

1

High-throughput

0.667

High

282429

MED13
Mediator of RNA polymerase II transcription subunit 13

3

2

High-throughput

0.662

High

282340

ESR1
Estrogen receptor

3

6

Small-scale

0.660

High

282359

SRBP1
Sterol regulatory element-binding protein 1

3

1

Small-scale

0.641

High

282403

ESR2
Estrogen receptor beta

3

5

Small-scale

0.641

High

259212

BRD4
Bromodomain-containing protein 4

3

3

Small-scale

0.640

High

282336

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

High-throughput

0.638

High

282382

MED22
Mediator of RNA polymerase II transcription subunit 22

3

0

High-throughput

0.638

High

282350

THA
Thyroid hormone receptor alpha

3

6

Small-scale

0.633

High

282379

NR1I3
Nuclear receptor subfamily 1 group I member 3

2

7

High-throughput

0.611

High

282395

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

2

2

High-throughput

0.611

High

282398

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

2

High-throughput

0.611

High

282356

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

282349

ANDR
Androgen receptor

2

5

Small-scale

0.586

High

282351

VDR
Vitamin D3 receptor

2

6

Small-scale

0.584

High

282388

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.553

High

282338

AACT
Alpha-1-antichymotrypsin

1

1

High-throughput

0.536

High

282385

SMAD2
Mothers against decapentaplegic homolog 2

1

5

Small-scale

0.515

High

282386

SMAD1
Mothers against decapentaplegic homolog 1

1

5

Small-scale

0.515

High

219893

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

282335

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.513

High

282344

LDHC
L-lactate dehydrogenase C chain

1

0

High-throughput

0.513

High

282346

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.513

High

282347

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

282358

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

282362

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

282378

IMB1
Importin subunit beta-1

1

0

High-throughput

0.513

High

282391

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

282366

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.508

High

282352

RXRA
Retinoic acid receptor RXR-alpha

1

4

Small-scale

0.501

High

282360

PPARG
Peroxisome proliferator-activated receptor gamma

1

7

Small-scale

0.501

High

282361

HNF4A
Hepatocyte nuclear factor 4-alpha

1

5

Small-scale

0.501

High

282373

PPARA
Peroxisome proliferator-activated receptor alpha

1

7

Small-scale

0.501

High

282363

SPB4
Serpin B4

1

1

High-throughput

0.489

High

282430

KS6A6
Ribosomal protein S6 kinase alpha-6

1

0

High-throughput

0.486

High

282435

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

Small-scale

0.480

High

142754

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

177634

SMAD7
Mothers against decapentaplegic homolog 7

1

5

Small-scale

0.479

High

181841

SMAD9
Mothers against decapentaplegic homolog 9

1

5

Small-scale

0.479

High

243486

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

1

High-throughput

0.479

High

282339

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

282345

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

282355

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.479

High

282367

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

282369

SMAD3
Mothers against decapentaplegic homolog 3

1

5

Small-scale

0.479

High

282374

NFIA
Nuclear factor 1 A-type

1

3

High-throughput

0.479

High

282377

NFIX
Nuclear factor 1 X-type

1

3

High-throughput

0.479

High

282381

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

282412

SMAD5
Mothers against decapentaplegic homolog 5

1

5

Small-scale

0.479

High

128670

MEN1
Menin

1

0

High-throughput

0.458

High

282334

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

282343

JUN
Transcription factor Jun

1

0

High-throughput

0.458

High

282348

PARP1
Poly [ADP-ribose] polymerase 1

1

0

Small-scale

0.458

High

282357

PML
Protein PML

1

0

High-throughput

0.458

High

282370

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

282371

TOP2B
DNA topoisomerase 2-beta

1

0

High-throughput

0.458

High

282376

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.458

High

282384

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

282387

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

282394

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

282399

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

282410

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

282413

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

282419

STN1
CST complex subunit STN1

1

0

High-throughput

0.458

High

282426

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

282404

KAT2A
Histone acetyltransferase KAT2A

1

4

Small-scale

0.445

High

282368

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

253925

LPXN
Leupaxin

1

0

High-throughput

0.426

High

282341

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

282372

ACVR1
Activin receptor type-1

1

0

High-throughput

0.426

High

282434

TRRAP
Transformation/transcription domain-associated protein

1

0

Small-scale

0.426

High

76419

B4DUB1
cyclin-dependent kinase

1

3

High-throughput

0.407

High

95741

E5RFK5
Cyclin-C

1

1

High-throughput

0.407

High

282365

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

282337

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

282380

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.279

Low

282397

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

282400

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

282401

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

0

High-throughput

0.279

Low

282405

KIFA3
Kinesin-associated protein 3

1

0

High-throughput

0.279

Low

282428

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.279

Low

164675

TNF11
Tumor necrosis factor ligand superfamily member 11

1

0

High-throughput

0.265

Low

282342

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

282389

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.249

Low

282392

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

282393

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

282402

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.249

Low

282418

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

282422

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.238

Low

262189

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.232

Low

282353

FPR1
fMet-Leu-Phe receptor

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025