Protein: NICA
Nicastrin

Gene: NICA, NCSTN
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q92542

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002262 - myeloid cell homeostasis
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1266767

PEN2
Gamma-secretase subunit PEN-2

6

3

Small-scale

0.931

High

834321

PSN1
Presenilin-1

12

6

Small-scale

0.755

High

1266753

APH1A
Gamma-secretase subunit APH-1A

10

6

Small-scale

0.751

High

654612

CALX
Calnexin

3

1

High-throughput

0.650

High

834995

PSN2
Presenilin-2

3

6

Small-scale

0.650

High

1150774

VASN
Vasorin

3

0

Small-scale

0.642

High

523088

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.628

High

299958

ERLN2
Erlin-2

2

1

Small-scale

0.611

High

933029

ACTS
Actin, alpha skeletal muscle

2

0

High-throughput

0.602

High

1185474

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

2

0

High-throughput

0.602

High

1255752

MICA1
[F-actin]-monooxygenase MICAL1

2

0

High-throughput

0.602

High

726333

BASI
Basigin

2

0

Small-scale

0.598

High

1266764

FBX6
F-box only protein 6

2

1

High-throughput

0.584

High

274589

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.536

High

393297

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.536

High

397460

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.536

High

433432

YES
Tyrosine-protein kinase Yes

1

2

High-throughput

0.536

High

505442

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.536

High

561643

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.536

High

617132

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

1

High-throughput

0.536

High

637007

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

1028514

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.536

High

1265922

CLC2B
C-type lectin domain family 2 member B

1

1

High-throughput

0.536

High

1266772

FBX2
F-box only protein 2

1

1

High-throughput

0.536

High

1266775

TEST
Testisin

1

1

High-throughput

0.536

High

156539

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.513

High

174120

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.513

High

303932

YIF1A
Protein YIF1A

1

0

High-throughput

0.513

High

355047

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

0

High-throughput

0.513

High

375984

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.513

High

486044

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.513

High

488086

RRAS
Ras-related protein R-Ras

1

0

High-throughput

0.513

High

530183

NCAM1
Neural cell adhesion molecule 1

1

0

High-throughput

0.513

High

665298

EPHA2
Ephrin type-A receptor 2

1

0

High-throughput

0.513

High

686341

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.513

High

946053

DLK1
Protein delta homolog 1

1

0

High-throughput

0.513

High

966095

LAT1
Large neutral amino acids transporter small subunit 1

1

0

High-throughput

0.513

High

1068315

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.513

High

1088579

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.513

High

1135418

WLS
Protein wntless homolog

1

0

High-throughput

0.513

High

1190940

TAFA1
Chemokine-like protein TAFA-1

1

0

High-throughput

0.513

High

1217489

AHNK2
Protein AHNAK2

1

0

High-throughput

0.513

High

1233314

PNKD
Probable hydrolase PNKD

1

0

High-throughput

0.513

High

1266755

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.513

High

1266756

F111A
Serine protease FAM111A

1

0

High-throughput

0.513

High

1266757

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1266761

MAGT1
Magnesium transporter protein 1

1

0

High-throughput

0.513

High

1266766

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.513

High

1266773

MAGD2
Melanoma-associated antigen D2

1

0

High-throughput

0.513

High

1266774

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.513

High

1266776

KC1G3
Casein kinase I isoform gamma-3

1

0

High-throughput

0.513

High

833287

TMEDA
Transmembrane emp24 domain-containing protein 10

1

1

Small-scale

0.500

High

846503

BLK
Tyrosine-protein kinase Blk

1

2

High-throughput

0.489

High

1075945

PCH2
Pachytene checkpoint protein 2 homolog

1

1

High-throughput

0.489

High

800930

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.480

High

882042

BACE1
Beta-secretase 1

1

0

Small-scale

0.480

High

555063

ANPRA
Atrial natriuretic peptide receptor 1

1

0

Small-scale

0.479

High

1048507

DAG1
Dystroglycan 1

1

0

Small-scale

0.479

High

1048633

DSG2
Desmoglein-2

1

0

Small-scale

0.479

High

1166338

PXDC2
Plexin domain-containing protein 2

1

0

Small-scale

0.479

High

1244977

DNER
Delta and Notch-like epidermal growth factor-related receptor

1

0

Small-scale

0.479

High

48441

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

385260

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

434253

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.479

High

572419

LEG3
Galectin-3

1

1

Small-scale

0.479

High

1087963

PTPRO
Receptor-type tyrosine-protein phosphatase O

1

1

High-throughput

0.479

High

1198115

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.479

High

1217059

PLD3
5'-3' exonuclease PLD3

1

1

High-throughput

0.479

High

1240705

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

1262269

APH1B
Gamma-secretase subunit APH-1B

1

6

Small-scale

0.479

High

1266754

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.479

High

1266768

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

1

High-throughput

0.479

High

489607

OSTP
Osteopontin

1

0

Small-scale

0.460

High

167990

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

205765

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

395353

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.458

High

547350

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.458

High

850126

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

967304

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1042173

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1165804

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1168611

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1266752

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1266765

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

110776

H7BXI1
Extended synaptotagmin 2

1

1

High-throughput

0.445

High

505533

GTR3
Solute carrier family 2, facilitated glucose transporter member 3

1

2

Small-scale

0.445

High

750875

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.445

High

59532

GSAP
Gamma-secretase-activating protein

1

1

Small-scale

0.437

High

119462

LEG9
Galectin-9

1

1

High-throughput

0.437

High

1199313

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

1

High-throughput

0.437

High

570269

NEUM
Neuromodulin

1

0

Small-scale

0.426

High

887916

CD81
CD81 antigen

1

0

High-throughput

0.426

High

901815

STXB1
Syntaxin-binding protein 1

1

0

Small-scale

0.426

High

1052451

FLOT2
Flotillin-2

1

0

Small-scale

0.426

High

456357

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.328

High

984406

EF1A2
Elongation factor 1-alpha 2

2

0

High-throughput

0.328

High

130166

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.279

Low

195930

TTI1
TELO2-interacting protein 1 homolog

1

0

High-throughput

0.279

Low

210573

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.279

Low

942057

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.279

Low

1072792

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.279

Low

1156653

TECT3
Tectonic-3

1

0

High-throughput

0.279

Low

1185324

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

0

High-throughput

0.279

Low

1266758

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.279

Low

1266759

CRNL1
Crooked neck-like protein 1

1

0

High-throughput

0.279

Low

1266760

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.279

Low

1266762

CA198
Uncharacterized protein C1orf198

1

0

High-throughput

0.279

Low

1266763

SFXN1
Sideroflexin-1

1

0

High-throughput

0.279

Low

1266771

TRM6
tRNA

1

0

High-throughput

0.279

Low

1266777

SQOR
Sulfide:quinone oxidoreductase, mitochondrial

1

0

High-throughput

0.279

Low

101015

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

553310

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651818

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

779823

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

941240

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1035522

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.249

Low

1119574

MIDN
Midnolin

1

0

High-throughput

0.249

Low

1171033

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1184235

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

1266769

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1266770

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024