Protein: GYS2
Glycogen [starch] synthase isoform 2 (EC 2.4.1.11)

Gene: GYS2, GSY2
Organism: Saccharomyces cerevisiae S288C
Interactions: 73
UniProt ID: P27472

Gene Ontology (top 5):
GO:0004373 - alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005978 - glycogen biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

692513

GLG2
Glycogenin-2

7

8

Small-scale

0.962

High

657171

GYS1
Glycogen [starch] synthase isoform 1

6

3

Small-scale

0.939

High

692482

GYS2
Glycogen [starch] synthase isoform 2

6

3

Small-scale

0.937

High

692499

GLG1
Glycogenin-1

4

8

High-throughput

0.893

High

602342

PHO85
Cyclin-dependent protein kinase PHO85

5

3

Small-scale

0.720

High

692492

PP12
Serine/threonine-protein phosphatase PP1-2

3

6

High-throughput

0.675

High

692517

PCL10
PHO85 cyclin-10

3

3

Small-scale

0.674

High

692511

PIG2
GSY2-interacting protein PIG2

3

11

Small-scale

0.664

High

692486

HRR25
Casein kinase I homolog HRR25

2

1

High-throughput

0.619

High

692527

GDE
Glycogen debranching enzyme

2

1

High-throughput

0.614

High

692509

GIP2
GLC7-interacting protein 2

2

11

High-throughput

0.611

High

692484

GAC1
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

2

11

Small-scale

0.596

High

666150

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

2

0

High-throughput

0.577

High

523231

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.552

High

544022

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.552

High

692510

SSB2
Ribosome-associated molecular chaperone SSB2

2

3

High-throughput

0.552

High

692488

PSK1
Serine/threonine-protein kinase PSK1

1

1

High-throughput

0.536

High

692529

PCL8
PHO85 cyclin-8

1

3

High-throughput

0.536

High

692500

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.518

High

686909

BUB3
Spindle assembly checkpoint protein BUB3

1

0

High-throughput

0.513

High

692487

BMH1
Protein BMH1

1

0

High-throughput

0.513

High

692521

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.513

High

692502

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.508

High

692525

PIG1
Serine/threonine-protein phosphatase 1 regulatory subunit PIG1

1

11

Small-scale

0.508

High

441055

KAPA
cAMP-dependent protein kinase type 1

1

1

High-throughput

0.501

High

642337

MCK1
Protein kinase MCK1

1

3

High-throughput

0.501

High

692483

CDC15
Cell division control protein 15

1

1

High-throughput

0.501

High

692501

AKL1
Serine/threonine-protein kinase AKL1

1

2

High-throughput

0.501

High

692503

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

3

High-throughput

0.501

High

692504

KSP1
Serine/threonine-protein kinase KSP1

1

5

High-throughput

0.501

High

692508

RSP5
E3 ubiquitin-protein ligase RSP5

1

2

High-throughput

0.501

High

692524

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

1

High-throughput

0.501

High

692530

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

3

High-throughput

0.501

High

692531

PKH2
Serine/threonine-protein kinase PKH2

1

2

High-throughput

0.501

High

692532

GIN4
Serine/threonine-protein kinase GIN4

1

1

High-throughput

0.501

High

368875

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

452485

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.493

High

682898

MSH2
DNA mismatch repair protein MSH2

1

0

High-throughput

0.493

High

692489

IMB3
Importin subunit beta-3

1

0

High-throughput

0.493

High

692519

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.489

High

692490

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.486

High

692512

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

1

0

High-throughput

0.486

High

364374

CDK1
Cyclin-dependent kinase 1

1

3

Small-scale

0.481

High

692515

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.480

High

692516

ENT3
Epsin-3

1

0

Small-scale

0.480

High

692528

ESA1
Histone acetyltransferase ESA1

1

0

Small-scale

0.480

High

446211

PHSG
Glycogen phosphorylase

1

2

High-throughput

0.479

High

578958

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.479

High

692485

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

692494

GLGB
1,4-alpha-glucan-branching enzyme

1

1

High-throughput

0.479

High

692496

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

692498

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.479

High

692507

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

692493

TOR2
Serine/threonine-protein kinase TOR2

1

0

High-throughput

0.460

High

692506

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.460

High

672857

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

679438

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

692497

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

692520

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

692522

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.458

High

692526

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

692533

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

692518

PDK2
[Pyruvate dehydrogenase

1

1

High-throughput

0.457

High

526070

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

670405

SIS1
Protein SIS1

1

2

High-throughput

0.445

High

675763

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

692491

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

692505

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

1

High-throughput

0.445

High

692514

BBC1
Myosin tail region-interacting protein MTI1

1

0

High-throughput

0.279

Low

613750

MDM10
Mitochondrial distribution and morphology protein 10

1

0

High-throughput

0.249

Low

692495

ATO2
Ammonia transport outward protein 2

1

0

High-throughput

0.249

Low

692523

NU100
Nucleoporin NUP100/NSP100

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025