Protein: LRS4
Monopolin complex subunit LRS4 (Loss of rDNA silencing protein 4)

Gene: LRS4
Organism: Saccharomyces cerevisiae S288C
Interactions: 77
UniProt ID: Q04087

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0033551 - monopolin complex
GO:0034503 - protein localization to nucleolar rDNA repeats

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

678897

CSM1
Monopolin complex subunit CSM1

12

0

Small-scale

0.933

High

864324

NET1
Nucleolar protein NET1

3

1

Small-scale

0.640

High

1026822

CDC14
Tyrosine-protein phosphatase CDC14

3

0

Small-scale

0.628

High

364727

CDK1
Cyclin-dependent kinase 1

2

0

High-throughput

0.598

High

381622

H2B2
Histone H2B.2

2

1

Small-scale

0.584

High

1035372

TOF2
Topoisomerase 1-associated factor 2

2

1

Small-scale

0.584

High

709459

HRR25
Casein kinase I homolog HRR25

2

0

Small-scale

0.569

High

817830

MAM1
Monopolin complex subunit MAM1

2

0

Small-scale

0.559

High

826070

ULP2
Ubiquitin-like-specific protease 2

2

0

Small-scale

0.559

High

826803

DSN1
Kinetochore-associated protein DSN1

2

0

Small-scale

0.559

High

440969

CDC7
Cell division control protein 7

1

1

Small-scale

0.515

High

794293

CHK1
Serine/threonine-protein kinase CHK1

1

0

High-throughput

0.513

High

1044076

VHS1
Serine/threonine-protein kinase VHS1

1

0

High-throughput

0.513

High

656610

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.501

High

740005

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

1

0

Small-scale

0.493

High

1045011

PRR2
Serine/threonine-protein kinase PRR2

1

1

High-throughput

0.489

High

441245

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

599402

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.480

High

1045010

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.480

High

381244

H2B1
Histone H2B.1

1

1

Small-scale

0.479

High

796121

IMB2
Importin subunit beta-2

1

1

Small-scale

0.479

High

749720

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

794848

CND2
Condensin complex subunit 2

1

0

Small-scale

0.460

High

796362

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

916743

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.460

High

382318

H4
Histone H4

1

0

Small-scale

0.458

High

415243

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

419860

H2A2
Histone H2A.2

1

0

Small-scale

0.458

High

459159

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

Small-scale

0.458

High

548798

MCM1
Pheromone receptor transcription factor

1

0

Small-scale

0.458

High

550080

RAP1
DNA-binding protein RAP1

1

0

Small-scale

0.458

High

566519

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

Small-scale

0.458

High

574816

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

1

0

Small-scale

0.458

High

597265

BIP
Endoplasmic reticulum chaperone BiP

1

0

Small-scale

0.458

High

646527

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

677701

MRC1
Mediator of replication checkpoint protein 1

1

0

High-throughput

0.458

High

680033

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

713589

RIF1
Telomere length regulator protein RIF1

1

0

Small-scale

0.458

High

745864

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

781798

SET3
SET domain-containing protein 3

1

0

Small-scale

0.458

High

794217

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

0

Small-scale

0.458

High

805633

LSM12
Protein LSM12

1

0

Small-scale

0.458

High

808904

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

809406

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

825177

NU159
Nucleoporin NUP159

1

0

Small-scale

0.458

High

919436

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.458

High

1038746

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

1039031

IMA1
Importin subunit alpha

1

0

Small-scale

0.458

High

1045002

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

1045005

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1045007

CSM4
Chromosome segregation in meiosis protein 4

1

0

Small-scale

0.458

High

1045009

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

393277

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

1043798

SRC1
Inner nuclear membrane protein SRC1

6

0

Small-scale

0.378

High

1045008

NUR1
Nuclear rim protein 1

4

0

Small-scale

0.362

High

917164

ATG1
Serine/threonine-protein kinase ATG1

1

0

High-throughput

0.261

Low

477627

MYO1
Myosin-1

1

0

High-throughput

0.251

Low

672456

STE50
Protein STE50

1

0

High-throughput

0.251

Low

813850

MBO1
Gamma tubulin complex adapter SPC72

1

0

High-throughput

0.251

Low

386851

TBB
Tubulin beta chain

1

0

Small-scale

0.249

Low

506209

AQY1
Aquaporin-1

1

0

Small-scale

0.249

Low

550692

SIR4
Regulatory protein SIR4

1

0

Small-scale

0.249

Low

698152

KRE2
Glycolipid 2-alpha-mannosyltransferase

1

0

Small-scale

0.249

Low

705669

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.249

Low

738508

NUP2
Nucleoporin NUP2

1

0

Small-scale

0.249

Low

739759

SPT16
FACT complex subunit SPT16

1

0

Small-scale

0.249

Low

751194

CSE1
Importin alpha re-exporter

1

0

Small-scale

0.249

Low

803845

YHK5
Putative uncharacterized protein YHR045W

1

0

Small-scale

0.249

Low

817821

NU157
Nucleoporin NUP157

1

0

Small-scale

0.249

Low

824540

6P21
6-phosphofructo-2-kinase 1

1

0

Small-scale

0.249

Low

864580

YJE9
Uncharacterized protein YJL049W

1

0

Small-scale

0.249

Low

1040100

PEX25
Peroxisomal membrane protein PEX25

1

0

Small-scale

0.249

Low

1045003

KU80
ATP-dependent DNA helicase II subunit 2

1

0

Small-scale

0.249

Low

1045004

NUP59
Nucleoporin ASM4

1

0

Small-scale

0.249

Low

1045006

YET3
Endoplasmic reticulum transmembrane protein 3

1

0

Small-scale

0.249

Low

1045012

CEX1
Cytoplasmic export protein 1

1

0

Small-scale

0.249

Low

780639

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025