Protein: DYHC
Dynein heavy chain, cytoplasmic (Dynein heavy chain, cytosolic) (DYHC)

Gene: DYHC, DYN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 110
UniProt ID: P36022

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000132 - establishment of mitotic spindle orientation
GO:0000235 - astral microtubule
GO:0000741 - karyogamy
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

779758

LIS1
Nuclear distribution protein PAC1

7

7

Small-scale

0.961

High

779738

DYHC
Dynein heavy chain, cytoplasmic

4

6

Small-scale

0.884

High

386669

TBB
Tubulin beta chain

3

1

Small-scale

0.845

High

486129

TBA1
Tubulin alpha-1 chain

3

2

Small-scale

0.845

High

779802

DYN3
Cytoplasmic dynein intermediate light chain DYN3

4

0

Small-scale

0.837

High

779792

DYL1
Dynein light chain 1, cytoplasmic

5

6

Small-scale

0.704

High

779789

NUM1
Nuclear migration protein NUM1

2

8

Small-scale

0.611

High

779750

KEL1
Kelch repeat-containing protein 1

2

2

High-throughput

0.595

High

779768

PAC11
WD repeat-containing protein PAC11

2

0

Small-scale

0.592

High

779813

RIO1
Serine/threonine-protein kinase RIO1

2

1

Small-scale

0.586

High

623834

MYO2
Myosin-2

2

2

Small-scale

0.584

High

779769

BNI1
Protein BNI1

2

2

Small-scale

0.584

High

598394

TUP1
General transcriptional corepressor TUP1

1

6

High-throughput

0.555

High

370468

ATIF
F(1)-ATPase inhibitor IF(1), mitochondrial

2

1

High-throughput

0.543

High

382027

H4
Histone H4

2

3

High-throughput

0.537

High

779810

KEL3
Kelch repeat-containing protein 3

1

2

High-throughput

0.515

High

747717

SMC1
Structural maintenance of chromosomes protein 1

1

1

High-throughput

0.508

High

779743

SHE1
Mitotic spindle-associated protein SHE1

1

0

Small-scale

0.504

High

704891

KIP2
Kinesin-like protein KIP2

1

1

Small-scale

0.501

High

779747

UMP1
Proteasome maturation factor UMP1

1

0

High-throughput

0.493

High

779784

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.486

High

466787

SWI5
Transcriptional factor SWI5

1

1

High-throughput

0.481

High

477547

MYO1
Myosin-1

1

3

High-throughput

0.481

High

548197

BIK1
Nuclear fusion protein BIK1

1

5

High-throughput

0.481

High

665807

KPC1
Protein kinase C-like 1

1

1

High-throughput

0.481

High

735611

SMY1
Kinesin-related protein SMY1

1

4

High-throughput

0.481

High

779741

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

2

High-throughput

0.481

High

779748

ETP1
RING finger protein ETP1

1

1

High-throughput

0.481

High

779752

END3
Actin cytoskeleton-regulatory complex protein END3

1

1

High-throughput

0.481

High

779754

RGA1
Rho-type GTPase-activating protein 1

1

1

High-throughput

0.481

High

779757

SNF7
Vacuolar-sorting protein SNF7

1

1

High-throughput

0.481

High

779763

TBP6
Probable 26S proteasome subunit YTA6

1

3

High-throughput

0.481

High

779776

HMS2
Probable transcription factor HMS2

1

1

High-throughput

0.481

High

779782

YG3A
Uncharacterized protein YGR130C

1

8

High-throughput

0.481

High

779785

CNM67
Chaotic nuclear migration protein 67

1

5

High-throughput

0.481

High

779786

CBK1
Serine/threonine-protein kinase CBK1

1

3

High-throughput

0.481

High

779798

VPS20
Vacuolar protein sorting-associated protein 20

1

1

High-throughput

0.481

High

779808

IRC3
Putative ATP-dependent helicase IRC3

1

1

High-throughput

0.481

High

779790

CDC14
Tyrosine-protein phosphatase CDC14

1

2

Small-scale

0.479

High

154355

YO304
Uncharacterized protein YOR304C-A

1

0

High-throughput

0.460

High

598477

SEN2
tRNA-splicing endonuclease subunit SEN2

1

0

High-throughput

0.460

High

672396

STE50
Protein STE50

1

0

High-throughput

0.460

High

750625

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.460

High

779739

SPC42
Spindle pole body component SPC42

1

0

High-throughput

0.460

High

779744

FL2D
Protein MUM2

1

0

High-throughput

0.460

High

779759

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.460

High

779762

VFA1
VPS4-associated protein 1

1

0

High-throughput

0.460

High

779772

SAC3
Nuclear mRNA export protein SAC3

1

0

High-throughput

0.460

High

779778

PSP1
Protein PSP1

1

0

High-throughput

0.460

High

779780

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.460

High

779787

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.460

High

779788

HSK3
DASH complex subunit HSK3

1

0

High-throughput

0.460

High

779791

CIK1
Spindle pole body-associated protein CIK1

1

0

High-throughput

0.460

High

779806

ARR1
Arsenical-resistance protein ARR1

1

0

High-throughput

0.460

High

779753

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.458

High

779812

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

370495

STF1
F(1)-ATPase inhibitor STF1, mitochondrial

1

1

High-throughput

0.439

High

700090

PRP45
Pre-mRNA-processing protein 45

1

1

Small-scale

0.439

High

777037

BDF1
Bromodomain-containing factor 1

1

1

High-throughput

0.439

High

779751

SKN7
Transcription factor SKN7

1

1

High-throughput

0.439

High

779756

HPH2
Protein HPH2

1

1

High-throughput

0.439

High

779761

TSC11
Target of rapamycin complex 2 subunit TSC11

1

1

High-throughput

0.439

High

779764

BNR1
BNI1-related protein 1

1

2

High-throughput

0.439

High

779765

NDC80
Kinetochore protein NDC80

1

12

High-throughput

0.439

High

779767

MAD1
Spindle assembly checkpoint component MAD1

1

11

High-throughput

0.439

High

779783

AP18B
Clathrin coat assembly protein AP180B

1

1

High-throughput

0.439

High

779817

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.439

High

779819

HPH1
Protein HPH1

1

1

High-throughput

0.439

High

668898

ERG6
Sterol 24-C-methyltransferase ERG6

2

0

Small-scale

0.326

High

779799

SPC24
Kinetochore protein SPC24

2

0

High-throughput

0.319

High

779760

SPC25
Kinetochore protein SPC25

2

0

High-throughput

0.310

High

779779

KNL1
Outer kinetochore KNL1 complex subunit SPC105

1

0

High-throughput

0.269

Low

639491

RE107
Recombination protein 107

1

0

High-throughput

0.251

Low

677747

STP22
Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease

1

0

High-throughput

0.251

Low

725960

SWC3
SWR1-complex protein 3

1

0

High-throughput

0.251

Low

749658

TYE7
Transcription factor TYE7

1

0

High-throughput

0.251

Low

779740

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.251

Low

779745

RXT2
Transcriptional regulatory protein RXT2

1

0

High-throughput

0.251

Low

779746

EXO84
Exocyst complex component EXO84

1

0

High-throughput

0.251

Low

779749

LAM4
Membrane-anchored lipid-binding protein LAM4

1

0

High-throughput

0.251

Low

779755

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.251

Low

779770

SPR3
Sporulation-regulated protein 3

1

0

High-throughput

0.251

Low

779771

BLM10
Proteasome activator BLM10

1

0

High-throughput

0.251

Low

779773

STB2
Protein STB2

1

0

High-throughput

0.251

Low

779774

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.251

Low

779775

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.251

Low

779777

CCM1
Mitochondrial 15S rRNA processing factor CCM1

1

0

High-throughput

0.251

Low

779781

NNF2
Protein NNF2

1

0

High-throughput

0.251

Low

779793

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

779795

RCF1
Respiratory supercomplex factor 1, mitochondrial

1

0

High-throughput

0.251

Low

779797

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

779800

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.251

Low

779801

IVY1
Protein IVY1

1

0

High-throughput

0.251

Low

779803

HOB2
Protein YPR117W

1

0

High-throughput

0.251

Low

779804

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.251

Low

779805

SEC10
Exocyst complex component SEC10

1

0

High-throughput

0.251

Low

779807

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.251

Low

779809

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

0

High-throughput

0.251

Low

779811

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

779814

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.251

Low

779815

NCA2
Nuclear control of ATPase protein 2

1

0

High-throughput

0.251

Low

779816

ERP3
Protein ERP3

1

0

High-throughput

0.251

Low

779818

NOP14
Nucleolar complex protein 14

1

0

High-throughput

0.251

Low

661496

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

706763

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

779742

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

779766

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

779796

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

779794

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025