Protein: 6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1 (EC 1.1.1.44)

Gene: 6PGD1, GND1
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P38720

Gene Ontology (top 5):
GO:0004616 - phosphogluconate dehydrogenase (decarboxylating) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0009051 - pentose-phosphate shunt, oxidative branch

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

802958

6PGD2
6-phosphogluconate dehydrogenase, decarboxylating 2

2

5

High-throughput

0.776

High

392677

HSP82
ATP-dependent molecular chaperone HSP82

3

2

High-throughput

0.658

High

670670

SIS1
Protein SIS1

3

1

High-throughput

0.643

High

802951

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

0

High-throughput

0.613

High

802929

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

5

Small-scale

0.575

High

544741

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.571

High

526602

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

802965

RAGAB
GTP-binding protein GTR1

2

0

Small-scale

0.551

High

604946

MDHM
Malate dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

656453

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.536

High

802940

HAT2
Histone acetyltransferase type B subunit 2

1

2

High-throughput

0.536

High

802956

KIP3
Kinesin-like protein KIP3

1

2

High-throughput

0.536

High

802959

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

802966

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

High-throughput

0.536

High

802967

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

802949

DSN1
Kinetochore-associated protein DSN1

2

1

High-throughput

0.521

High

449410

SPT2
Protein SPT2

1

0

High-throughput

0.513

High

802963

EF3B
Elongation factor 3B

1

0

High-throughput

0.513

High

602440

PHO85
Cyclin-dependent protein kinase PHO85

1

2

High-throughput

0.501

High

802939

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

High-throughput

0.501

High

617390

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.500

High

802977

IMH1
Golgin IMH1

1

1

High-throughput

0.500

High

802931

ARO9
Aromatic amino acid aminotransferase 2

1

0

High-throughput

0.493

High

724874

RAD16
DNA repair protein RAD16

1

2

High-throughput

0.489

High

802969

UTP17
NET1-associated nuclear protein 1

1

2

High-throughput

0.489

High

802974

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.489

High

802975

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.489

High

625958

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

Small-scale

0.480

High

802954

ENT3
Epsin-3

1

0

Small-scale

0.480

High

394522

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.479

High

751392

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

802937

RV167
Reduced viability upon starvation protein 167

1

0

High-throughput

0.479

High

365613

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.479

High

367748

ENO1
Enolase 1

1

2

High-throughput

0.479

High

367958

ENO2
Enolase 2

1

2

High-throughput

0.479

High

455042

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

575939

CYPH
Peptidyl-prolyl cis-trans isomerase

1

1

High-throughput

0.479

High

579331

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

655569

TKT1
Transketolase 1

1

1

High-throughput

0.479

High

663314

FPS1
Glycerol uptake/efflux facilitator protein

1

3

High-throughput

0.479

High

679641

CDC48
Cell division control protein 48

1

4

High-throughput

0.479

High

726997

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

743198

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.479

High

752212

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

785916

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

802952

DUG1
Cys-Gly metallodipeptidase DUG1

1

1

High-throughput

0.479

High

802961

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

802970

ESP1
Separin

1

1

High-throughput

0.479

High

802972

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

802982

ATG9
Autophagy-related protein 9

1

1

High-throughput

0.479

High

368439

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

401990

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

416427

HXKA
Hexokinase-1

1

0

High-throughput

0.458

High

432322

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

441888

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

450718

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

452572

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

514620

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

572571

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

578231

TAL1
Transaldolase

1

0

High-throughput

0.458

High

647098

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

734960

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

748739

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.458

High

750648

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

778308

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

802930

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

802933

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

802935

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

802938

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

802942

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

802947

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

802957

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

802962

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

802971

COFI
Cofilin

1

0

High-throughput

0.458

High

802978

SGO1
Shugoshin

1

0

High-throughput

0.458

High

802981

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

750239

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.457

High

802983

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

585925

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.457

High

622944

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.457

High

754535

PEX6
Peroxisomal ATPase PEX6

1

5

High-throughput

0.457

High

802936

RBG1
Ribosome-interacting GTPase 1

1

1

High-throughput

0.457

High

802953

YJ66
Uncharacterized oxidoreductase YJR096W

1

5

High-throughput

0.457

High

625007

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

802955

SEH1
Nucleoporin SEH1

1

1

High-throughput

0.457

High

523830

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

689205

RL16B
Large ribosomal subunit protein uL13B

1

1

High-throughput

0.445

High

689433

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.445

High

802943

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

802944

RL13B
Large ribosomal subunit protein eL13B

1

1

High-throughput

0.445

High

802948

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

802968

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

802960

IST1
Vacuolar protein sorting-associated protein IST1

1

0

High-throughput

0.438

High

802964

ARP4
Actin-related protein 4

1

1

High-throughput

0.437

High

802973

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

383682

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.426

High

802934

ATC2
Calcium-transporting ATPase 2

1

1

High-throughput

0.417

High

802941

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.296

High

459085

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

684071

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.279

Low

802932

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.279

Low

802945

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

1

0

High-throughput

0.261

Low

802976

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.261

Low

748168

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

506453

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

707003

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

748376

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

802950

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.249

Low

802979

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

802984

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

802980

FLC1
Flavin carrier protein 1

1

0

High-throughput

0.238

Low

802946

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025