Protein: HOSM
Homocitrate synthase, mitochondrial (HCS) (EC 2.3.3.14)

Gene: HOSM, LYS21
Organism: Saccharomyces cerevisiae S288C
Interactions: 66
UniProt ID: Q12122

Gene Ontology (top 5):
GO:0004410 - homocitrate synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0019878 - lysine biosynthetic process via aminoadipic acid
GO:0046872 - metal ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

874350

HOSC
Homocitrate synthase, cytosolic isozyme

4

14

High-throughput

0.896

High

1084331

HOSM
Homocitrate synthase, mitochondrial

1

14

High-throughput

0.698

High

525496

HSP71
Heat shock protein SSA1

4

9

High-throughput

0.666

High

850252

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

5

High-throughput

0.640

High

393504

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.614

High

527978

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

820084

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

454497

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.536

High

923919

SYC
Cysteine--tRNA ligase

1

1

High-throughput

0.515

High

602686

PHO85
Cyclin-dependent protein kinase PHO85

1

4

High-throughput

0.501

High

651997

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

1

High-throughput

0.501

High

750320

PRP40
Pre-mRNA-processing protein PRP40

1

1

High-throughput

0.501

High

801953

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

849934

WWM1
WW domain-containing protein WWM1

1

1

High-throughput

0.501

High

863968

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

1

High-throughput

0.501

High

1084335

SKM1
Serine/threonine-protein kinase SKM1

1

1

High-throughput

0.501

High

735580

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.493

High

448823

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

580232

HSC82
ATP-dependent molecular chaperone HSC82

1

8

High-throughput

0.479

High

594630

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

668325

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

671232

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

680151

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

708496

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

727391

HS104
Heat shock protein 104

1

6

High-throughput

0.479

High

735220

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

736407

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.479

High

739486

ZUO1
Zuotin

1

5

Small-scale

0.479

High

748092

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

750799

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

792305

GBLP
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

803716

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

918717

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.479

High

1025063

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.479

High

1044168

GIS1
Transcriptional activator/repressor GIS1

1

1

High-throughput

0.479

High

1044500

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

1084275

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

1084332

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

1084333

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

649251

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

806834

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

815273

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

825817

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

826922

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

849724

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

919042

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

1084334

PRR2
Serine/threonine-protein kinase PRR2

1

4

High-throughput

0.457

High

546686

SSB1
Ribosome-associated molecular chaperone SSB1

1

10

High-throughput

0.445

High

597301

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

742642

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

816470

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

825491

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

574942

SAM35
Sorting assembly machinery 35 kDa subunit

1

0

High-throughput

0.438

High

558899

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

760636

TSA1
Peroxiredoxin TSA1

1

1

Small-scale

0.437

High

922694

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.437

High

811191

TCPZ
T-complex protein 1 subunit zeta

1

4

High-throughput

0.407

High

1056451

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

818152

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.296

High

515343

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

798700

YB8A
Putative uncharacterized protein YBR285W

1

0

Small-scale

0.249

Low

812135

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

877934

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

836952

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

858089

RSSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025