Protein: SEC2
Rab guanine nucleotide exchange factor SEC2 (GDP-GTP exchange factor SEC2)

Gene: SEC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P17065

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005934 - cellular bud tip
GO:0005935 - cellular bud neck
GO:0006887 - exocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

458527

SEC4
Ras-related protein SEC4

11

5

Small-scale

0.979

High

600698

YPT32
GTP-binding protein YPT32/YPT11

4

4

Small-scale

0.888

High

600647

SEC2
Rab guanine nucleotide exchange factor SEC2

4

4

Small-scale

0.881

High

600652

SEC15
Exocyst complex component SEC15

5

0

Small-scale

0.684

High

600702

CBK1
Serine/threonine-protein kinase CBK1

2

1

Small-scale

0.625

High

600654

KC12
Casein kinase I homolog 2

2

2

Small-scale

0.619

High

600680

YPT31
GTP-binding protein YPT31/YPT8

1

4

Small-scale

0.618

High

600700

ATG1
Serine/threonine-protein kinase ATG1

3

0

Small-scale

0.618

High

600678

AKL1
Serine/threonine-protein kinase AKL1

2

2

High-throughput

0.602

High

477509

MYO1
Myosin-1

2

0

Small-scale

0.583

High

600719

VAM6
Vacuolar morphogenesis protein 6

2

0

High-throughput

0.561

High

600666

SMY1
Kinesin-related protein SMY1

2

0

Small-scale

0.559

High

525846

HSP72
Heat shock protein SSA2

2

1

High-throughput

0.552

High

600684

KSP1
Serine/threonine-protein kinase KSP1

2

2

High-throughput

0.550

High

600716

SEC10
Exocyst complex component SEC10

1

0

Small-scale

0.537

High

600691

FKH1
Fork head protein homolog 1

1

1

High-throughput

0.536

High

439228

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.513

High

600662

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

600677

EF1G2
Elongation factor 1-gamma 2

1

0

High-throughput

0.513

High

600718

ELP1
Elongator complex protein 1

1

0

Small-scale

0.504

High

364312

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.501

High

440823

KIN28
Serine/threonine-protein kinase KIN28

1

1

High-throughput

0.501

High

600650

DBF2
Cell cycle protein kinase DBF2

1

1

High-throughput

0.501

High

600656

KCC4
Probable serine/threonine-protein kinase KCC4

1

3

High-throughput

0.501

High

600669

IME2
Meiosis induction protein kinase IME2/SME1

1

3

High-throughput

0.501

High

600672

SWE1
Mitosis inhibitor protein kinase SWE1

1

1

High-throughput

0.501

High

600674

HSL1
Probable serine/threonine-protein kinase HSL1

1

3

High-throughput

0.501

High

600692

PRK1
Actin-regulating kinase PRK1

1

3

High-throughput

0.501

High

600703

ARK1
Actin-regulating kinase 1

1

4

High-throughput

0.501

High

600706

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

2

High-throughput

0.501

High

600708

KIN4
Serine/threonine-protein kinase KIN4

1

3

High-throughput

0.501

High

600711

STE20
Serine/threonine-protein kinase STE20

1

2

High-throughput

0.501

High

600722

GIN4
Serine/threonine-protein kinase GIN4

1

4

High-throughput

0.501

High

441024

KAPA
cAMP-dependent protein kinase type 1

1

0

High-throughput

0.480

High

448634

SNF1
Carbon catabolite-derepressing protein kinase

1

0

High-throughput

0.480

High

574627

KSS1
Mitogen-activated protein kinase KSS1

1

0

High-throughput

0.480

High

600699

SCY1
Protein kinase-like protein SCY1

1

0

High-throughput

0.480

High

600705

SEC5
Exocyst complex component SEC5

1

0

Small-scale

0.480

High

600651

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.479

High

600724

TRS33
Trafficking protein particle complex subunit 33

1

2

Small-scale

0.479

High

600673

NIP80
Protein NIP100

1

0

High-throughput

0.460

High

600686

END3
Actin cytoskeleton-regulatory complex protein END3

1

0

High-throughput

0.460

High

479960

PRTB
Cerevisin

1

0

High-throughput

0.458

High

600657

SRO9
RNA-binding protein SRO9

1

0

High-throughput

0.458

High

600663

SEC1
Protein transport protein SEC1

1

0

Small-scale

0.458

High

600670

SEC8
Exocyst complex component SEC8

1

0

Small-scale

0.458

High

600671

TRS65
Trafficking protein particle complex II-specific subunit 65

1

0

Small-scale

0.458

High

600689

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

600696

MOB2
CBK1 kinase activator protein MOB2

1

0

Small-scale

0.458

High

600721

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

0

High-throughput

0.458

High

600649

MCK1
Protein kinase MCK1

1

1

High-throughput

0.457

High

600653

KC11
Casein kinase I homolog 1

1

2

High-throughput

0.457

High

600658

KCC1
Calcium/calmodulin-dependent protein kinase I

1

1

High-throughput

0.457

High

600660

PRR1
Serine/threonine-protein kinase PRR1

1

1

High-throughput

0.457

High

600665

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.457

High

600681

RIM11
Serine/threonine-protein kinase RIM11/MSD1

1

1

High-throughput

0.457

High

600682

RCK1
Serine/threonine-protein kinase RCK1

1

2

High-throughput

0.457

High

600683

RCK2
Serine/threonine-protein kinase RCK2

1

2

High-throughput

0.457

High

600709

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

1

High-throughput

0.457

High

600723

SKM1
Serine/threonine-protein kinase SKM1

1

3

High-throughput

0.457

High

522968

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.445

High

600707

SED5
Integral membrane protein SED5

1

1

High-throughput

0.439

High

600710

YMZ2
WD repeat-containing protein YMR102C

1

1

High-throughput

0.437

High

394201

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

543723

SSB1
Ribosome-associated molecular chaperone SSB1

1

0

High-throughput

0.426

High

578787

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.426

High

600688

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

600648

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.407

High

600667

MET4
Transcriptional activator of sulfur metabolism MET4

2

0

High-throughput

0.310

High

597025

BIP
Endoplasmic reticulum chaperone BiP

2

0

High-throughput

0.300

High

486012

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.279

Low

600668

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.279

Low

600679

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.279

Low

600685

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.279

Low

600695

GCN20
Protein GCN20

1

0

High-throughput

0.279

Low

600704

ACT
Actin

1

0

High-throughput

0.279

Low

600712

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.279

Low

600664

COPG
Coatomer subunit gamma

1

0

High-throughput

0.269

Low

600720

HRK1
Serine/threonine-protein kinase HRK1

1

0

High-throughput

0.261

Low

600655

BOS1
Protein transport protein BOS1

1

0

High-throughput

0.251

Low

600675

BLI1
Biogenesis of lysosome-related organelles complex 1 subunit BLI1

1

0

High-throughput

0.251

Low

600676

YKF0
Uncharacterized protein YKL050C

1

0

High-throughput

0.251

Low

600690

NDC80
Kinetochore protein NDC80

1

0

High-throughput

0.251

Low

600693

MAD1
Spindle assembly checkpoint component MAD1

1

0

High-throughput

0.251

Low

600697

BUD27
Bud site selection protein 27

1

0

High-throughput

0.251

Low

600701

PRS10
26S proteasome subunit RPT4

1

0

High-throughput

0.251

Low

600713

SPC19
DASH complex subunit SPC19

1

0

High-throughput

0.251

Low

600715

SHE9
Sensitive to high expression protein 9, mitochondrial

1

0

High-throughput

0.251

Low

600717

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.251

Low

600659

CBPS
Carboxypeptidase S

1

0

High-throughput

0.249

Low

600661

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

600714

MUS81
Crossover junction endonuclease MUS81

1

0

High-throughput

0.249

Low

364911

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low

386554

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

575375

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

591986

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

600687

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.232

Low

600694

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025